DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KDM4A and kdm4ab

DIOPT Version :9

Sequence 1:	NP_055478.2	Gene:	KDM4A / 9682	HGNCID:	22978	Length:	1064	Species:	Homo sapiens
Sequence 2:	XP_001339664.2	Gene:	kdm4ab / 334347	ZFINID:	ZDB-GENE-030131-6279	Length:	1045	Species:	Danio rerio

Alignment Length:	1109	Identity:	679/1109 - (61%)
Similarity:	790/1109 - (71%)	Gaps:	109/1109 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASESETLNPSAR-IMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDD 64
            |||:.    |.:| ||||:||:|||:||||||||:||||||:|||||:||||.||||.|||||||
Zfish     1 MASDM----PVSRGIMTFHPTVEEFKNFSRYIAYMESQGAHKAGLAKIVPPKNWKPRGSYDDIDD 61

Human    65 LVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNP 129
            |:|||||||:||||||||||||||||||||:||||.|||||:|:|||.:|||||||||||:||||
Zfish    62 LIIPAPIQQVVTGQSGLFTQYNIQKKAMTVKEFRKTANSDKFCSPRYDDFEELERKYWKNVTFNP 126

Human   130 PIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDL 194
            ||||||||||||:..:.|||:|.|.||||.||.|||||||||||||||||||||:||||||||||
Zfish   127 PIYGADVNGTLYDPDIKEWNVGHLNTILDTVEHESGITIEGVNTPYLYFGMWKTTFAWHTEDMDL 191

Human   195 YSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDK 259
            |||||||||||||||:||||||||||||||||||||:|:||||||||||||||.:||||||||:|
Zfish   192 YSINYLHFGEPKSWYTVPPEHGKRLERLAKGFFPGSSQNCEAFLRHKMTLISPSILKKYGIPFEK 256

Human   260 VTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKF 324
            :||||||||:||||||||||||||||||||||||||||:|||||:|||||||||||||||||:||
Zfish   257 ITQEAGEFMVTFPYGYHAGFNHGFNCAESTNFATRRWIDYGKQAILCSCRKDMVKISMDVFVKKF 321

Human   325 QPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELPPRAGNEEECPEEDMEGVEDGEEGDLKTSL 389
            |||||:||..||||..|||:.|||||||||         |.|....|..:|  ....||. |.||
Zfish   322 QPERYELWLEGKDNAPIDHSKPTPEAAEFL---------GGEAGAQELRIE--NQSNEGQ-KKSL 374

Human   390 AKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFP 454
            ||.|||||||||||:.|:||     .||.:                    |:......:.|...|
Zfish   375 AKQRIGTKRHRVCLDFPEEV-----LPKTE--------------------TNDEAEYGKKGRLTP 414

Human   455 DYSDS----TEVKFEE----------LKNV--KLEEEDEEEEQAAAALDLSVNPASVGGRLVFSG 503
             |::.    ||:|.|:          ||.:  ....|..|..:.|...|..::..:.......:.
Zfish   415 -YTEQCKEYTELKHEDRTLPLMGSTSLKMLPGSRSAEFSENVRGAGFSDADLDAKATSHISACAQ 478

Human   504 SKKKSSSSLGSG-------SSRDSISSDSETSEPLSCRAQGQTGVLTVHSYAKGDGRVTVGEPCT 561
            ...|...|:.|.       |:...:|:....:..|..|....|..|.|||||   .:..:.:|.|
Zfish   479 PFPKHHLSIASVPTVPHCLSAVPRVSTKPGVASLLFHRTLSPTDALQVHSYA---AKAALCKPQT 540

Human   562 RKKGSAARSFSERELA-----------------EVADEYMFSLEENKKSKGRRQPLSKLPRHHPL 609
            .............:::                 |:..|     :||...|.:.||||||||.|||
Zfish   541 PSPEKPREDLHIPDISLDVRPNTPTPPPDTPEHEIEGE-----KENNSMKRKLQPLSKLPRLHPL 600

Human   610 VLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIF 674
             |:|..||||..|   |..|.|||:.|||.|:.:||:|..||:.|||||..|....|:||||.:|
Zfish   601 -LRENSSDDEIQE---PTAEPEETDPWAKILAPMWQSRQRNFQIEKEFNFRMGLHPPYCAVCSLF 661

Human   675 QTYHQ---VEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDINLSTPYLEEDGTSILV 736
            .||::   :..|||....||       .||||||||||||||   |::.:||||.||.||||.|:
Zfish   662 HTYNESDVISLGGFAAVGGN-------PQRTKPLIPEMCFTS---SSEGHLSTPNLEADGTSQLI 716

Human   737 SCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVA 801
            ||..||||||.|||||......:.|.||||.|||:.:||||||||||||||||:|:||||.||||
Zfish   717 SCSVCSVRVHTSCYGVSQDAKLDSWRCSRCEANAITQDCCLCSLRGGALQRANNDKWVHVLCAVA 781

Human   802 ILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGV 866
            :|||||||||||.|||:|.||..||||||.||:|..|:|.|||||||||||.|:||.:|||||||
Zfish   782 VLEARFVNIAERRPVDLSTIPFQRFKLKCQFCRKWVKKTTGCCVQCSHGRCSTSFHATCAQAAGV 846

Human   867 MMQPDDWPFVVFITCFRHK-IPNLERAKGALQSITAGQKVISKHKNGRFYQCEVVRLTTETFYEV 930
            .|.||||||||:.||:||| ..::||...:::.:..|||||.||||||:|.||||.||..|||||
Zfish   847 QMHPDDWPFVVYFTCWRHKGGTHIERNMASMRELEKGQKVICKHKNGRYYHCEVVELTKATFYEV 911

Human   931 NFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQ 995
            .||||||||||:|||||::||.:.|||:|||||||:||||.:||||||:.|.|.||||||||.||
Zfish   912 IFDDGSFSDNLFPEDIVNRDCTRHGPPSEGEVVQVQWTDGLIYGAKFVSDHIIPMYQVEFEDDSQ 976

Human   996 LVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYR 1060
            |.|||:||::|||||||||||||||||||||..:|.||||||:.||||||||||||||||||:||
Zfish   977 LTVKREDVFSLDEELPKRVKSRLSVASDMRFKGVFVEKEVKQDSKRQRVINSRYREDYIEPAIYR 1041

Human  1061 AIME 1064
            ||:|
Zfish  1042 AILE 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDM4A	NP_055478.2	JmjN	13..55	CDD:128818	34/42 (81%)
		JmjC	175..291	CDD:202224	106/115 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..384		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..537		7/42 (17%)
		Interaction with NCOR1. /evidence=ECO:0000269\|PubMed:16024779	597..638		24/40 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..641		13/24 (54%)
		PHD_JMJD2A	667..766	CDD:277050	54/101 (53%)
		ePHD_JMJD2A	775..884	CDD:277183	84/108 (78%)
		TUDOR	897..953	CDD:197660	40/55 (73%)
		TUDOR	955..1010	CDD:197660	41/54 (76%)
kdm4ab	XP_001339664.2	JmjN	10..52	CDD:128818	33/41 (80%)
		JmjC	172..288	CDD:202224	106/115 (92%)
		PHD_SF	654..746	CDD:304600	54/101 (53%)
		ePHD_JMJD2A	755..864	CDD:277183	84/108 (78%)
		TUDOR	879..932	CDD:197660	38/52 (73%)
		TUDOR	936..991	CDD:197660	41/54 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I9790
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52663
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		oto51372
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	15	15.320