DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KDM4A and kdm4aa

DIOPT Version :9

Sequence 1:	NP_055478.2	Gene:	KDM4A / 9682	HGNCID:	22978	Length:	1064	Species:	Homo sapiens
Sequence 2:	XP_001921829.2	Gene:	kdm4aa / 100003413	ZFINID:	ZDB-GENE-110609-4	Length:	2012	Species:	Danio rerio

Alignment Length:	2039	Identity:	696/2039 - (34%)
Similarity:	833/2039 - (40%)	Gaps:	1002/2039 - (49%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASES---ETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDI 62
            |||:|   .:.:|:.|||||:||.|||::|:|||||:|||||||||:|||||||:||||.:||||
Zfish     1 MASDSVSQSSQSPATRIMTFHPTKEEFKDFNRYIAYMESQGAHRAGMAKVVPPKDWKPRRTYDDI 65

Human    63 DDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTF 127
            :|||||.||||:||||||||||||||||.||||||||.||:||:..|||::|||||||:||||||
Zfish    66 EDLVIPTPIQQVVTGQSGLFTQYNIQKKPMTVREFRKTANTDKFSNPRYADFEELERKFWKNLTF 130

Human   128 NPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDM 192
            |||:|||||:||||:..|.|||||||.||||:||:||||||:|||||||||||||::||||||||
Zfish   131 NPPLYGADVSGTLYDPDVMEWNIGRLNTILDMVERESGITIKGVNTPYLYFGMWKSTFAWHTEDM 195

Human   193 DLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPF 257
            |||||||||||||||||.|||||||||||||||||||||||||||||||||||||.:|:||||||
Zfish   196 DLYSINYLHFGEPKSWYVVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPSILRKYGIPF 260

Human   258 DKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVR 322
            :|||||||:|::||||||||||||||||||||||||:|||:|||.|.|||||||||||||||||.
Zfish   261 EKVTQEAGQFIVTFPYGYHAGFNHGFNCAESTNFATQRWIDYGKLATLCSCRKDMVKISMDVFVH 325

Human   323 KFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESE------------LPPRAGNEEECPEEDME 375
            ||||||||||||||||..|||:.||||.||..||:|            |..|  .|.|..::...
Zfish   326 KFQPERYKLWKAGKDNVPIDHSKPTPEVAEIQKENEKGEISDSERAETLEER--GEAEAGDQQKA 388

Human   376 GVEDGEEG---------------------------------------DLKTSLAKHRIGTKRHR- 400
            ..:||||.                                       .:.:|..|...|.||.|
Zfish   389 NTDDGEEDKAEAFSEKVVKRESDAGKEKAEAEVEKSVRDEEPSSTSEQISSSSPKQNTGQKRLRS 453

Human   401 --------------------------------------------------------------VCL 403
                                                                          .|:
Zfish   454 STDNEAKDDNQVKIEVEEVEKKKAKLGQNETDNNEEQSVSAEPDDEKAEETMETDTPPPQQQECM 518

Human   404 EI-------------------------------------------------------------PQ 407
            |.                                                             |:
Zfish   519 EAELSTSDPTSSSDITTQQREEESSDVTSSTQSINSVDEDVALGGDVASQSEDVTQSFVVQINPE 583

Human   408 EVSQSEL---------------------------------------------------------- 414
            :::.::|
Zfish   584 DITPTDLTDAQPSNITSHPCSSDIPATSFMSVSSSNFSKHSISFAYTCDGTTEPSDSINLTPRVP 648

Human   415 ----------------------------------------------------------------- 414

Zfish   649 SINVAHISDVQPEPSDIIVSLKQNSSANSTYTSDVQSDLSNVTVDPEHKPSINSTHIINVQSETS 713

Human   415 --------------FPKEDLSSE---QYEMTECPAALAPVRPTHSSVRQ---VEDGLTFPDYSDS 459
                          .|..|:.||   :||.....|.:..|:|.||.:..   .:.|:.|...||.
Zfish   714 NITISSEHEPSISSTPMSDVQSETSFKYEPGNNSAYVCDVKPEHSDISMSPIYKPGVNFAHTSDV 778

Human   460 TEVKFE---------------ELKNVKLEEEDEEEEQAAAALDLSVNP-------------ASVG 496
            .....|               |..::.:..:||....:|...|:...|             :|..
Zfish   779 QPEPSECESCTNSDHICDVQSEANDIIINSKDEMSINSAHTFDVQPEPSDNTVSLTHKPDISSTS 843

Human   497 GRLVFSG---------------------------------------------------------- 503
            |..|.||
Zfish   844 GSDVPSGPGDITDSLGYDPDFNSTHTGHVQSESNNSPKHKLPINSAHTYDVQSGPSDITDGHRFE 908

Human   504 ---------------------SKKKSS---------------SSLGS------------------ 514
                                 ||:|||               .|:||
Zfish   909 SEFNSTHICDVQSGPSDMSVNSKRKSSIDSAQIDDAQSDPSDISIGSKQEYSINSAQIDNVQSEP 973

Human   515 -----GSSRD------------------------------------------------------- 519
                 ||.::
Zfish   974 SDISIGSKQESSINSAQIDNVQSEPSNISISSKQETSINSTQIDDVQSEPSDISISSKNKLRINS 1038

Human   520 -------------SISSDSET------------------------------------SEPL---- 531
                         |:||:.||                                    |||:
Zfish  1039 AQIDDVQSAPSGISVSSEQETSIISAQVDDVQSEYSDISISSKHEPSINSTQTDDIQSEPIDISF 1103

Human   532 -----SC---------------------------------------------------------- 533
                 ||
Zfish  1104 GSKQESCINSAQMYDVQSEPSDISISSTQETSINSAQMYDVQLEPSDISISFKDKPSINSSQVDD 1168

Human   534 ----------------------------------------------------------------- 533

Zfish  1169 VQSEPSDICFGSEQETCINSAQIYDVQSEPSNISFSSKQETSINSTQMYDVQSEPSDISISSNQE 1233

Human   534 ----------------------------------------------------------------- 533

Zfish  1234 TSINSTQMYDVQSEPSDISISSNQETSINSTQMYDVQSEPSDISISSNQETSINSTQMHDVQSEP 1298

Human   534 ----------------------------------------------------------------- 533

Zfish  1299 SDISISSNQETTINSTQMYDVQSDPSDISISSKHKPSINSARMYDVQSEPSDISISSKHNPSIDS 1363

Human   534 ----------------------------------------------------------------- 533

Zfish  1364 TQMFDVQSEPSDFSISSKHKPSIDSTQIYDVQSAPSGLTISYKQKTSINSAQMYEVQSEPSDFSV 1428

Human   534 ----------------------------------------------------------------- 533

Zfish  1429 SSKRKPSIDSIHMYDDVQLKSSNFMVSRTPEPTYKIIPEPSSSVSVNVSGLSSVLASVSQGSVQH 1493

Human   534 ---RAQGQTGVLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKG 595
               |......||.||||||||  .:..||         |...||:    :|....|.::|||...
Zfish  1494 IFQRTLSPAEVLHVHSYAKGD--YSDIEP---------RIQHERD----SDSDSESQDDNKKEAE 1543

Human   596 R----RQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKE 656
            |    :..|.:|||||||: ::.:||:|..:|...||:..:.||||:||:|||||||.|.:.|:|
Zfish  1544 RPAEAQYRLPRLPRHHPLI-KDSISDEELQDQAASEEDGLDGEAWARPLTQLWQNRPYNPDRERE 1607

Human   657 FNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASD----LAPQKQRTKPLIPEMCFT-STGC 716
            :|..|..:.|:|::||:||.:|:.|        |..|:    |...:.||||||||.||| :|..
Zfish  1608 YNREMGLRPPYCSICMLFQAHHRSE--------GAESEPAVVLRGGQMRTKPLIPERCFTITTEE 1664

Human   717 STDINLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLR 781
            |.|:..||.:|||||||:|:||..||||||.|||||...:.|:||.|:||.|||..|.|||||||
Zfish  1665 SADVQPSTAHLEEDGTSLLISCSLCSVRVHTSCYGVASGRVSKDWKCARCKANAFAESCCLCSLR 1729

Human   782 GGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQ 846
            ||||.|||:.:||||.||||:.|||||||.||||||:|.|||.||||||.:||:|.|:|.|||||
Zfish  1730 GGALHRANNGKWVHVLCAVAVQEARFVNITERSPVDLSGIPLQRFKLKCYYCKRRMKKTLGCCVQ 1794

Human   847 CSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIP-NLERAKGALQSITAGQKVISKHK 910
            ||||||||::|.:|||||||:|.||||||||::||.|||.| ..||.|.|::.::.||:||.|||
Zfish  1795 CSHGRCPTSYHPTCAQAAGVIMHPDDWPFVVYVTCCRHKGPVQSERNKSAMRELSVGQRVICKHK 1859

Human   911 NGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGA 975
            |||:|||||::||.|||||||||||||||||:|||||::||.|.|||.:|||||||||||.||||
Zfish  1860 NGRYYQCEVIQLTKETFYEVNFDDGSFSDNLFPEDIVNRDCAQLGPPPQGEVVQVRWTDGLVYGA 1924

Human   976 KFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKK 1040
            ||||:|.||||||||||||.|..|||||||||||||||||||||.||||||:.:|.||:| ||.|
Zfish  1925 KFVAAHVIQMYQVEFEDGSLLTAKRDDVYTLDEELPKRVKSRLSKASDMRFDGMFGEKKV-QESK 1988

Human  1041 RQRVINSRYREDYIEPALYRAIME 1064
            ||||||||||.|||||.:||||||
Zfish  1989 RQRVINSRYRGDYIEPVIYRAIME 2012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDM4A	NP_055478.2	JmjN	13..55	CDD:128818	33/41 (80%)
		JmjC	175..291	CDD:202224	105/115 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..384		9/76 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..537		23/651 (4%)
		Interaction with NCOR1. /evidence=ECO:0000269\|PubMed:16024779	597..638		17/40 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..641		11/24 (46%)
		PHD_JMJD2A	667..766	CDD:277050	51/103 (50%)
		ePHD_JMJD2A	775..884	CDD:277183	82/108 (76%)
		TUDOR	897..953	CDD:197660	41/55 (75%)
		TUDOR	955..1010	CDD:197660	46/54 (85%)
kdm4aa	XP_001921829.2	JmjN	16..58	CDD:128818	33/41 (80%)
		JmjC	178..294	CDD:202224	105/115 (91%)
		PHD_SF	1618..1714	CDD:304600	51/103 (50%)
		PHD_SF	1723..1832	CDD:304600	82/108 (76%)
		TUDOR	1847..1902	CDD:197660	41/54 (76%)
		TUDOR	1904..1959	CDD:197660	46/54 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	264	1.000	Domainoid score	I8973
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H27780
Inparanoid	1	1.050	1312	1.000	Inparanoid score	I1323
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	15	15.360