Protein Alignment DEPDC5 and depdc5

DIOPT Version :10

• Sequence 1: NP_001229825.1
• Gene: DEPDC5 / 9681
• HGNCID: 18423
• Length: 1603
• Species: Homo sapiens
• Sequence 2: XP_021334975.1
• Gene: depdc5 / 562995
• ZFINID: ZDB-GENE-091204-356
• Length: 1614
• Species: Danio rerio
• Alignment Length: 1637
• Identity: 1224/1637 - (74%)
• Similarity: 1367/1637 - (83%)
• Gaps: 61/1637 - (3%)

Human     1 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKE 65
            |:..|.||||:||||||||||||::||||||.:||||||||||||||||||||||||||||||||
Zfish     5 MKANKSYKLVVHKKGFGGSDDELMMNPKVFPQVKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKE 69

Human    66 TISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQ 130
            ||||||||.|.|:||.||||.:|:||||:|||||||||||||||||||||||||||||||||:||
Zfish    70 TISVDQTVAQAFKLRAYQDVIINIVDPKEVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYVTQ 134

Human   131 KVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKA 195
            |||||||||||.|||||.|||.|||||||||||||||||||||||||||||||||||||||||||
Zfish   135 KVEFAGIRAQASELWVKGEKVTCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKA 199

Human   196 VNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQ 260
            |||||:|||.|||||||||||||||||||||.||:::||||..|||:||||:||:|||||:||.|
Zfish   200 VNGFLSDLFAKWKEKNCSHEVTVVLFSRTFYSAKTLEEFPESQRASVRQDHEGRYYEDFYRVVAQ 264

Human   261 NERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRN 325
            ||||:||.|||||||||||||||||||:.|:|||.|.||||||||||||||||||||||||||||
Zfish   265 NERRDEWMSLLVTIKKLFIQYPVLVRLKGADGFPCGHNSTSAQGNYLEAINLSFNVFDKHYINRN 329

Human   326 FDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPRD 390
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:...|
Zfish   330 FDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRTVHGD 394

Human   391 SRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESENALPI 455
            ||:|||||:||||||||||||||..|:.|||||||||||..:|||||.::.|||:||::||:|||
Zfish   395 SRIGDDYNLPHWINHSFYTSKSQNSCSCFTPRIKLAGKKVHAEKAKNSKEHSLGAPKDAENSLPI 459

Human   456 QVDYDAYDAQVFRLPGPSRAQCLT-----------TCRSVRERESHSRKSASSCDVSSSPSLPSR 509
            ||||||||:||||||||||||..|           :.||.|||||.||||..|.||.|||  |:|
Zfish   460 QVDYDAYDSQVFRLPGPSRAQRSTNFSSSHINSTDSNRSSRERESVSRKSWGSADVGSSP--PNR 522

Human   510 TLPTEEVRSQASDDSSLGKSANILMIPHPHLHQYEVSSSLGYTS-TRDVLENMMEPPQRDSSAPG 573
            ....:|.||.|||| |||..:|||:||.|...|||||||||||| ||::||.|:| .||||||||
Zfish   523 HTGPDEQRSLASDD-SLGHMSNILLIPRPAQGQYEVSSSLGYTSCTRELLEKMVE-SQRDSSAPG 585

Human   574 RFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQ 638
            ||.||||||.|||||||||||||||||||||||||||||||||||||||||||||.|||||||||
Zfish   586 RFTVGSAESTLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEPIQIHHQTRQ 650

Human   639 NMAELQGSGQRDPTHSSAELLELAYHEAAG-RHSNSRQPGDGMSFL-----NFSGTEELSVGLLS 697
            ||||||||.||||..:||||||||||||.| :.:.||..|:...::     |.||:...|    |
Zfish   651 NMAELQGSEQRDPARTSAELLELAYHEATGSKRTASRHAGENGLYISGVPDNISGSPASS----S 711

Human   698 NSGAGMNPRTQNKDSLEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPD 762
            ::|..:     |:.|.|| .|.|.||||.|||||.||.|||||||||||||||||||||||||||
Zfish   712 STGTPV-----NRGSFED-YSGSLDPILLLSAPPTVPSFCCTVGVDWKSLTTPACLPLTTDYFPD 770

Human   763 RQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVP 827
            ||.||||||||||||||..|::|||::...|||.||||||||||||||||||||| .:||.||:.
Zfish   771 RQTLQNDYTEGCYDLLPHTDLERRDDETPVMTAHQVFEEFICQRLMQGYQIIVQP-NRKPQPAIA 834

Human   828 PPLSSSPLYSRGLVSRNRPEEEDQ-YWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYS 891
            ||||||||||||||||.:||||:. ||||||||||||.||||:||||||||||||||.||.|:|:
Zfish   835 PPLSSSPLYSRGLVSRRKPEEEESLYWLSMGRTFHKVCLKDKIITVTRYLPKYPYESTQIQYSYN 899

Human   892 LCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTAT 956
            |||.|:|:.|:..||||||||||||||||||||||||||||||||:||||||||||||||  ...
Zfish   900 LCPPHADAHFMPFWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIDSLKFWRTRFLLLPA--GGA 962

Human   957 KRITEGEAHCDIYGDRPRADED------EWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGL 1015
            :|:.:||.|.|:||:...|..|      :|.|||||:||:|||||||||||||||:|||..:|||
Zfish   963 RRVADGEGHWDVYGEGAGAGRDGLAGTGDWTLLDGFIRFLEGLNRIRRRHRSDRMIRKGATIKGL 1027

Human  1016 QMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQ-AAVHGGKSSAQSAESSSVAMT 1079
            |:||.:::::.|..|||:|||||||||||||:|.:||...||| ||.||||.....:|:::||:|
Zfish  1028 QVTGALTSYTPEPIAPPLGKKGTSALSALLELEQTQKTFEEQQLAAQHGGKPCGPFSEAANVALT 1092

Human  1080 PTYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQT-ATPMLDGTSLGICTGQSMDRGNSQTFG 1143
            .|::||||||.||.::|:|||| :|...:.|:..:|. |.|:..|.|     .:..::...:|..
Zfish  1093 TTFVDSPRKDAAFILDFIRSPR-SSYICHSQLPAEQVPANPIEGGLS-----DKISNQPGERTSA 1151

Human  1144 NSQNIGE--QGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFI 1206
            .||..|:  .|.|......|.|..|   ||:|||||.|||||:|||:||||||.||:||.|.||:
Zfish  1152 ASQATGDPTPGASLETGGQSGSSGL---SLSSSSTLMEILEAIKHPTTGVQLLPEQRGLPPNCFV 1213

Human  1207 SAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAM 1271
            |||||||||:.||.:.||.:|::||||||||.|||||||:|.|||:||||||:|| ||:.::..:
Zfish  1214 SAEVVHWLVSTVENVATQGIAVEIMQKMLEEGLITHASGDAMRTFVYGFYFYRIV-DKDNEKAPL 1277

Human  1272 QQ----PATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSR 1332
            .|    .|..|..|.::|||.|||||||||||.||....::||||||||||||||||||||||||
Zfish  1278 TQLPPAGANVWSAAALEDFALFQRKWFEVAFVMEERRPCDLPAFLLPWLPSRPASYASRHSSFSR 1342

Human  1333 SFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAV 1397
            |||||||||||||||||||:|||||||||||:||.||||||||||||||||||||||||||||||
Zfish  1343 SFGGRSQAAALLAATVPEQKTVTLDVDVNNRSDRTEWCSCYYHGNFSLNAAFEIKLHWMAVTAAV 1407

Human  1398 LFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEP 1462
            ||||||||||||.|||||||||||.||||.||||||||||||||||||.|||||||::||:.|||
Zfish  1408 LFEMVQGWHRKAASCGFLLVPVLEVPFALSSYLYGDPLRAQLFIPLNIQCLLKEGSDNLFEGFEP 1472

Human  1463 ETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRR 1527
            |||||||.||||||..||||||||:||||||||:|||||||||||||||||||||||:|..||||
Zfish  1473 ETYWDRMQLFQEAILTRFGFVQDKFSASAFNFPSENKPQYIHVTGTVFLQLPYSKRKYSSGQRRR 1537

Human  1528 RNSTSSTNQNMF-CEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFW 1591
            ||||:||||::| .||||||||||||||||.||:...||||.|||||:||||||.|:||||||||
Zfish  1538 RNSTTSTNQSLFGSEERVGYNWAYNTMLTKAWRTGVLGDEKLADRLLRDFTDFCANKDNRLVTFW 1602

Human  1592 TSCLEKMHASAP 1603
            .||:|||:||||
Zfish  1603 ESCVEKMNASAP 1614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DEPDC5	NP_001229825.1	IML1	101..381	CDD:463510	255/279 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	427..450		13/22 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..527		25/42 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	696..720		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1135..1165		8/31 (26%)
		DEP_DEPDC5-like	1179..1260	CDD:239896	60/80 (75%)
		DEPDC5_CTD	1278..1585	CDD:466071	261/307 (85%)
depdc5	XP_021334975.1	IML1	105..385	CDD:463510	255/279 (91%)
		DEP_DEPDC5-like	1184..1267	CDD:239896	61/82 (74%)
		DEPDC5_CTD	1288..1596	CDD:466071	261/307 (85%)