Protein Alignment DEPDC5 and Iml1

DIOPT Version :10

• Sequence 1: NP_001229825.1
• Gene: DEPDC5 / 9681
• HGNCID: 18423
• Length: 1603
• Species: Homo sapiens
• Sequence 2: NP_728621.1
• Gene: Iml1 / 38176
• FlyBaseID: FBgn0035227
• Length: 1544
• Species: Drosophila melanogaster
• Alignment Length: 1720
• Identity: 602/1720 - (35%)
• Similarity: 867/1720 - (50%)
• Gaps: 326/1720 - (18%)

Human     5 KVYKLVIHKKGFGGS-DDELVVNPKVFPHIKLGDIVEIAHPNDEY-SPLLLQVKSLKEDLQKETI 67
            |:|||..|.:|...| |.:||:|.|..|:..:||:|||..|::|. :.||||:........::.|
  Fly     2 KLYKLNTHTRGCNKSYDADLVMNLKDHPNANVGDVVEIYAPDEENGTHLLLQITEFNGSCGRDVI 66

Human    68 SVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKV 132
            |::..:...|::|||.:|.:.:|.|.||.||.:|:||||||:||.:|||||..|..||.|:.:|:
  Fly    67 SIESGIANAFKMRPYSNVVMRIVKPADVALDSIEITFKDQYMGRSEMWRLKTYLTDTCVYVNKKI 131

Human   133 EF--AGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKA 195
            ::  ..||.|..|:|.:.|:|..|.|:|||::||||:::|||:|:|||.|||||||:||||||||
  Fly   132 DYNDMQIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMWDFDIHGDLYFEKA 196

Human   196 VNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQ 260
            |||||.:||.||::.:|:||||:||||||||.|||:|||||..|..::||:|||||||||:|.:|
  Fly   197 VNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPEHMRDCLQQDYKGRFYEDFYRVAIQ 261

Human   261 NERREEWTSLLVTIKKLFIQYPVLV-RLEQAEG--FPQGDNSTSAQGNYLEAINLSFNVFDKHYI 322
            |||.::|.::|..::|||..|...| |..:.|.  .|...||::.|||:||.:|:|.|.|:|||:
  Fly   262 NERCDDWCTVLGQLRKLFTSYQATVLRYHERENMKIPPATNSSATQGNFLEVLNISLNTFEKHYL 326

Human   323 NRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSA 387
            :|.||||||:|||||||||||.|||.|..:||||:||||:|.||||:||||||||||.|.||:..
  Fly   327 DRTFDRTGQLSVVITPGVGVFSVDRELTNITKQRIIDNGVGSDLVCVGEQPLHAVPLLKFHNKDT 391

Human   388 PRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLA--GKKPA-------SEKAKNGRD-TS 442
            ...|  .|||::|||||.|||::..::..:||.|||||.  |.:..       .|..:|.|. .|
  Fly   392 TLTS--ADDYSLPHWINLSFYSTNKKIVYSSFIPRIKLPLFGSQLTLHDGVGDGEGEENERHFLS 454

Human   443 LGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLP 507
            ....:...|:|   .||||||.|:|: |.|:::.| :..|.||.::            :|.|||.
  Fly   455 CNQSEYKHNSL---FDYDAYDEQIFQ-PLPAQSTC-SLQRVVRAKK------------TSVPSLE 502

Human   508 S---------RTLPTE--EVRSQASD-DSSLGKSANILMIPHPHLHQYEVSSSLGYTSTRDVLEN 560
            :         ...||:  .:|.:.|| |...|.|| :|....|.......|.:....|.|.::
  Fly   503 TYAYRNNDWENLTPTQIPAMRRKMSDPDIHHGTSA-MLAALQPDTTNLSESLASEKNSRRTIV-- 564

Human   561 MMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGP 625
                    |.||            .||||     |||||||.||::.:|||||||||.|.||.||
  Fly   565 --------SIAP------------IVRPG-----RALINPFDPSQVTIKLTSNRRRWTHIFPKGP 604

Human   626 SGEAIQIHH---------QTRQN--MAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDG 679
            :|..||.||         |..|.  :.:.|.:...|......|..|  .::....||...:....
  Fly   605 TGVLIQQHHYQAVPAKPTQAGQQRPLQQTQSNNNNDQEDYGCENGE--QYDRVSSHSLLNKSDSS 667

Human   680 MSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSL------------------EDSVST------- 719
            .||:  .|.|.:.. ......:.|||:..|..:|                  ..:::|
  Fly   668 QSFV--MGDEPIDF-FKRRQNSPMNPQPANVPNLTATQAKSYLWGATGEQEWTPAITTVKHLRPI 729

Human   720 ---------SPDPILTLSAPP----------VVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQG 765
                     |.:.:..|..||          ::      :||||||||.|||||:|||||||::.
  Fly   730 VEGEHHHLGSLEALRALDPPPDAEAGGGRGKII------IGVDWKSLTIPACLPITTDYFPDKRS 788

Human   766 LQNDYTEGCYDLLPEADIDRRDEDGVQ--------MTAQQVFEEFICQRLMQGYQIIVQPKTQKP 822
            |.|||....|.|||: |:   :.|..|        ::.::|.:|.:.|||.||:|:||..:
  Fly   789 LNNDYVISDYTLLPD-DV---NHDYAQSRAVYRKPLSTEEVCKEIVSQRLAQGFQLIVVDE---- 845

Human   823 NPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIH 887
            .|......||........:||   |...:|.||:||.|||::|...:||||.|.|::||....:.
  Fly   846 KPPTASGCSSGSAVQPVKLSR---ETNKEYLLSIGRIFHKISLSGSVITVTGYRPRHPYPPINVD 907

Human   888 YTYSL-CPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLP- 950
            |.|.. .|.|...|...  |.|:.|:||.:.||::|.|||:.|..|:.|:||||:||.|..|||
  Fly   908 YRYRFHAPQHETYEISG--VNFTTEKLENFNWNHMDLYICTRGDVDYPLMESLKYWRYRMYLLPR 970

Human   951 ----ACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTA 1011
                :.:.:.:|       |||:.| ..||....|:.| |||.:|.:::::|::     .||...
  Fly   971 ENIVSKIASCQR-------CDIFPD-VTADNTREQVED-FVRLIEAVSKLKRQY-----ARKARY 1021

Human  1012 MKGLQMTGPIS-----THSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSA 1071
            :..|....||:     .||....:.|...:|.:
  Fly  1022 LASLLQDSPIAHITKRRHSTSIISRPQPNQGLT-------------------------------- 1054

Human  1072 ESSSVAMTPTYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDR 1136
                        :||      |.|.|.|.|.....  |.::|    .|.|:...:
  Fly  1055 ------------NSP------FRERVGSNRLPEKR--PSINV----RPKLENGRI---------- 1085

Human  1137 GNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLS 1201
              .:.|..:......|.::.:..|....  |....:.::||.||.||||||..||...|:.:.|.
  Fly  1086 --PRIFPATDAAAAAGVAARDDQDDGFP--VDIKFSPNATLPEIFEAMKHPVNGVGFFSQTQSLP 1146

Human  1202 PYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEP 1266
            ...|:|.:.:.||...   :......:|:::.|.:|::|.||||:..:..:.||.||.:|   :.
  Fly  1147 SCTFVSYDALMWLKTR---LNNGRHPLDLLEAMRKERMICHASGDWKKPVVPGFVFYYVV---QQ 1205

Human  1267 DRVAMQQPATTWHTAGVDDFASFQRKWFEVAFVA------EELVHSEIPAFLLPWLPSRPASYAS 1325
            |:.|..      :...:||:::|..:|.|:.|..      :|.|.:.:|.|    |...||..:.
  Fly  1206 DKNAKD------YAPPLDDYSAFVNEWLEIEFQGCSFLWHDEPVTTPVPNF----LRDSPAPQSW 1260

Human  1326 RHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHW 1390
            ..:|.::....:|.                |::|||.::||:||....:|.......||||.:.|
  Fly  1261 TETSSNKRVYRQSH----------------LEIDVNQKSDRMEWGHVKHHTVLQPRFAFEIVVEW 1309

Human  1391 MAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEH 1455
            :..:..::.:::.||.|||....| ||.|...|.|.|.....||||..:|||| .:..|..|:.
  Fly  1310 VTSSGPIVADLIGGWMRKANQFNF-LVSVPADPMAEPFTKKSDPLRGPIFIPL-CTTFLPNGAA- 1371

Human  1456 LFDSFEPETYWDRMHLFQEAIAHRFGF----VQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYS 1516
            |||.|..|:..|||..|||||..:|||    ::.|||... :.|.|.  ||:|.||.:|..:..:
  Fly  1372 LFDEFPEESRSDRMLFFQEAILGKFGFLPCVLEKKYSVGK-DLPKEY--QYVHCTGNMFALIRCA 1433

Human  1517 KRKFSGQQ---------RRRRNSTSSTNQNMFCEERVGYNWAYNTML-TKTWR-----SSATGDE 1566
            ...:..:.         |.....|::||    ..::||:.||:|.|: .|.|:     :||.| |
  Fly  1434 TNNYQVESPILKEANVTRCVYGHTNNTN----VPKKVGFLWAWNHMIPNKKWKAQTINNSADG-E 1493

Human  1567 KFADRLLKDFTDFCINRDNRLVTFWTSCLE 1596
            .|..::||||.:||.|.|.||.||||...|
  Fly  1494 LFQLKMLKDFREFCSNSDQRLSTFWTQSQE 1523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DEPDC5	NP_001229825.1	IML1	101..381	CDD:463510	173/284 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	427..450		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..527		12/54 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	696..720		6/57 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1135..1165		3/29 (10%)
		DEP_DEPDC5-like	1179..1260	CDD:239896	28/80 (35%)
		DEPDC5_CTD	1278..1585	CDD:466071	102/331 (31%)
Iml1	NP_728621.1	IML1	100..385	CDD:463510	173/284 (61%)
		DEP_DEPDC5-like	1122..1202	CDD:239896	29/82 (35%)
		DEPDC5_CTD	1216..1511	CDD:466071	102/325 (31%)