Protein Alignment DEPDC5 and iml1

DIOPT Version :10

• Sequence 1: NP_001229825.1
• Gene: DEPDC5 / 9681
• HGNCID: 18423
• Length: 1603
• Species: Homo sapiens
• Sequence 2: NP_596645.1
• Gene: iml1 / 2540559
• PomBaseID: SPBC26H8.04C
• Length: 1496
• Species: Schizosaccharomyces pombe
• Alignment Length: 1747
• Identity: 404/1747 - (23%)
• Similarity: 647/1747 - (37%)
• Gaps: 490/1747 - (28%)

Human    21 DELVVNPKVFPHIKLGDIVEI-------------------AHPNDEYSPLLLQVKSLKEDLQKE- 65
            ::.|:|..:.|..|.|||.||                   .|...|..|:.|....|.:||::.
pombe    17 NDAVLNYDLVPSAKPGDIFEIRAQNGDEIALQHNHSSTGKLHAKREKEPVYLMPSPLTDDLKRRH 81

Human    66 ---TISVDQTVTQVFRLRPYQDVYVNVVDPK-DVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCA 126
               .:||...::.:..::..:.|.|.:.:.| ::..:.|.:.|:||:|.|.|||:|.:.|...|.
pombe    82 PNLQLSVVSHISSLLNIKNREPVVVKICEDKTNLEAEHVVIFFRDQFISRSDMWKLFRELCGKCV 146

Human   127 YITQKVEFAG-IRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDL 190
            |:.|:|.|.| :..:...:|.|.:|....||||.|:.:|||.||...||||||.|||.|:..|:|
pombe   147 YLKQRVSFIGDVPGEIRCIWRKGKKCHSAYISERTKPIFRSESARFLIFIQMSEEMWHFEEDGEL 211

Human   191 YFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFY----------------DAKSVDEFPEIN- 238
            .:.||::|||.|||:.|::....|.|:::||:|..|                ..|....:|:.:
pombe   212 NYNKAIDGFLPDLFSFWRDLGTHHLVSIILFTRVEYSHHGPMCVWQPRSQKNSEKGSSIYPQNSF 276

Human   239 RASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIK---KLFIQYPVLVRLEQAEG----FPQG 296
            .|||  |::|..||||:||||.|....:|..:|..:|   ..|.|..::.:::...|    :..|
pombe   277 NASI--DNEGGPYEDFFKVVVDNVSSRDWQPVLANLKLELAKFRQDVIVRKIKDENGREIEYICG 339

Human   297 DNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNG 361
            ..:.|.:||:||.||::...|...||:|:..|||...:::|||.|::||:..::.||.:.:::..
pombe   340 RMTGSQEGNFLEVINMAVFQFQSDYIDRDLSRTGTSIIIVTPGTGLYEVNEKMLHLTSKSLLNTV 404

Human   362 IGVDLVCMGEQPLHAVPLFKLHN-----RSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTP 421
            :|:|:|.:|:.||...|:.:..|     :.:...||:....:..:.|.:|..:|.|....:||..
pombe   405 VGMDIVSLGKVPLFLTPIVRYKNPVKNKKRSQLTSRISSSVSPSNVIPNSLTSSVSNFSVSSFLN 469

Human   422 RIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFR-LPGP----SRAQCLTTC 481
            .:|              .||      |.....||..:...|.....| |..|    .|.......
pombe   470 NLK--------------EDT------EWLYTFPIGCNISFYSTTEMRSLRSPWENLMREHQFEPT 514

Human   482 RSVRERESHSRKSASSCDVS-----SSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHLH 541
            ..:.|.:......|.|..:|     |.|.|..... :|||:....:....|::|
pombe   515 AKMHELQMMGVLEAESAKISIPLLQSDPLLKGSVF-SEEVQEDYDERQFTGEAA----------- 567

Human   542 QYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQ-----------R 595
                      .|..|||         .||:|..|   |:.:.::|....|...           :
pombe   568 ----------VSANDVL---------SSSSPRHF---SSHTPVNVDKSSYLEMNGHSLSTVISGK 610

Human   596 ALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE 660
            ..|:.|......:|.||  :.....|......|.:|   :...|.:.:..|.|...::.|:.|.:
pombe   611 ESISSFGAKVDDLKSTS--KESARQFGKSALTERLQ---KLAGNSSNVSSSLQTSSSNKSSLLTK 670

Human   661 LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMN--PRTQNKDSLEDSVSTSPDP 723
                       .|..|.....||....|...|...|........  |...|:||......:...|
pombe   671 -----------KSSFPALLKGFLALPATVTTSANPLGFKSTIQRPIPIKNNEDSDSCKAFSQAPP 724

Human   724 ILTLSAP----PVVPGFCCTV-------------------------------------------- 740
            |.|...|    |..|.:..||
pombe   725 IATKKPPTFLKPNSPEYAKTVIPKSSTNLENEYQTPWKIIQNPFKLKETTADNDPVSLRWEHLYM 789

Human   741 ------GVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVF 799
                  ..:|.|:.||..||||..|||..:.|.:.:.|..|.:       ..|.:..||..|::.
pombe   790 KVQDVRKFNWLSMCTPGALPLTFSYFPSEEELNDKFEEYTYTI-------GIDPEFTQMNQQELL 847

Human   800 EEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPL---------YSRGLVSRNRPE---EEDQY 852
            .|.|||||.:||||:|       |||.....|.:|.         :||.:.::....   ..|..
pombe   848 AEMICQRLSRGYQIVV-------NPAAAVSYSGNPKANKAGTITDFSRSVNNQRNGHLTVGSDAV 905

Human   853 WLSMGRT-FHKVTLKDKM---ITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFSHERL 913
            .||:|.: ||:::. |.:   |.|.||:.|...: .::.|.|:.. |.::.::|...:.||....
pombe   906 CLSLGDSQFHRLSC-DSVGYNIEVKRYVKKVSGQ-GKMRYDYNFW-SKNECKYVKSNITFSANDS 967

Human   914 EEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEA--HCDIYGDRPRAD 976
            ..|.|||:||.||  |.|.: |.:|:|:||.||:|||...|:|....:.:.  |.|...|
pombe   968 ANYNWNYVDQLIC--GFETY-LPDSVKYWRARFVLLPMSTTSTHVFQKYQLLDHADALSD----- 1024

Human   977 EDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSAL 1041
             :|::        |||:.::.......::.....:......|.|.....::.|..|:.:...|.|
pombe  1025 -EEFR--------VEGIYKLSELLYKGKIDPMNDSNNKTPNTSPAELLGIKFTTLPMAQYIHSEL 1080

Human  1042 SALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKDGAFFMEFVRSPRTASSA 1106
            .||                                     .:||.|.:.:.||...|
pombe  1081 EAL-------------------------------------RLDSSRNEQSLFMPNKR-------- 1100

Human  1107 FYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSL 1171
                                                                            |
pombe  1101 ----------------------------------------------------------------L 1101

Human  1172 TSSSTLTEILEAMKHPSTGVQL--LSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKM 1234
            ..|:.|..|.:.::.|. |.::  ::....:...||:.:|.|.||.|...||.|:..|:....|:
pombe  1102 DCSADLHTIAKEIQGPG-GPKIDDITWHYRIYENCFLGSEFVSWLANTFIGINTREEALKYGNKL 1165

Human  1235 LEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQRKWFEVAFV 1299
            |...|..||..:  ...:.|:|.|:|..|.....|: .:|               .|.||
pombe  1166 LSLGLFDHALKK--HPLLDGYYVYRISPDYSIKPVS-NRP---------------YRSWF----- 1207

Human  1300 AEELVHSEIPAFLLPWLPSRPASYASRH---SSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVN 1361
                              ||......:|   ...:.|..|.|:        :...|.:..:.||.
pombe  1208 ------------------SRKKDSGQKHLDNKIITESEAGPSR--------LELSRRILFNADVE 1246

Human  1362 NRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLV--PVLE--- 1421
            .:..:.|..:.:|....:..:.:.|::.|:..||:|:.:::|.|.|.....|..||  |:.|
pombe  1247 KKNGKSETVTVHYDLLHNPASCYHIRIEWLLATASVIEKLLQSWSRILERYGLKLVEAPIHEIAA 1311

Human  1422 ----GPFALPSYLY------GDPLRAQLF-IPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEA 1475
                .||...|.:.      ..|.||.|. .|:|.|                :.:|:      ..
pombe  1312 VGELNPFDQVSIISLALDPPPIPERAPLVNDPVNYS----------------KNWWN------VK 1354

Human  1476 IAHRFGFVQDKYSASAFNFPAE-------NKP-----QYIHVTGTVFLQLPYSKRKFSGQQRRRR 1528
            |...|.|:.|..:||  .||..       .||     ||||.||||.:|:...:| |.....|..
pombe  1355 ILEHFDFILDTEAAS--TFPKSITAVYSWGKPNFRYVQYIHRTGTVLVQIDDDQR-FLWLPNRLH 1416

Human  1529 NSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGD-EKFADRLLKDFTDFCINRD 1584
            ||..|                 ....||:.:|:...: ::.|:.|.:.|.:||.|:|
pombe  1417 NSKVS-----------------KLSFTKSNKSTLNPNLKETAEELERKFREFCSNKD 1456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DEPDC5	NP_001229825.1	IML1	101..381	CDD:463510	108/304 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	427..450		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..527		10/47 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	696..720		5/25 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1135..1165		0/29 (0%)
		DEP_DEPDC5-like	1179..1260	CDD:239896	22/82 (27%)
		DEPDC5_CTD	1278..1585	CDD:466071	73/339 (22%)
iml1	NP_596645.1	IML1	122..424	CDD:463510	108/303 (36%)
		DEP_DEPDC5-like	1107..1189	CDD:239896	23/84 (27%)
		DEPDC5_CTD	1206..1456	CDD:466071	71/322 (22%)