Protein Alignment DEPDC5 and depd-5

DIOPT Version :10

• Sequence 1: NP_001229825.1
• Gene: DEPDC5 / 9681
• HGNCID: 18423
• Length: 1603
• Species: Homo sapiens
• Sequence 2: NP_001420386.1
• Gene: depd-5 / 175548
• WormBaseID: WBGene00011604
• Length: 1718
• Species: Caenorhabditis elegans
• Alignment Length: 1901
• Identity: 453/1901 - (23%)
• Similarity: 703/1901 - (36%)
• Gaps: 616/1901 - (32%)

Human     2 RTTKVYKLVIHKKGFGGSD-DELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLL----------QV 55
            |.::||.....:......| ||.||..|       ...|.|..|.|....|.|          ::
 Worm   131 RNSRVYDEAARQAVLAELDKDEDVVEKK-------KSSVMIGKPEDVTCTLSLAKGAPGLITNRI 188

Human    56 KSLKE-DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKK 119
            ..||: |:.|.|:....|                      |:||.|:|||::||:.|.||:|.:.
 Worm   189 DFLKQNDIVKCTLETVDT----------------------VSLDNVQLTFREQYMSRADMYRYRS 231

Human   120 SLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDF 184
            .|:....|:.:...:..|..:..::|.|...|..||:::.|||||||:|:.|.|||||..||...
 Worm   232 CLIGRMTYVEEPKRYMNINTRISDMWRKGSLVRSGYVTDKTRVVFRSSSSTVLIFIQMCSEMNQL 296

Human   185 DIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIR-----Q 244
            |..||||.||.:.|||.:||.||||::|:|.|:::|.|| :|....||:      |:.|     .
 Worm   297 DPQGDLYLEKCIKGFLTELFLKWKEQSCTHYVSIILCSR-WYAIGGVDD------AAKRFMKGAC 354

Human   245 DHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFI---QYPVLVRLEQAEGFP--QGDNSTSAQG 304
            ||:||:|:|||:::.|||..|:|..  ..:|::.:   :|...::.:..|..|  |.:.||:|.|
 Worm   355 DHRGRYYQDFYRLLFQNEHYEDWAD--KQLKEINVGCSKYSSQIQEKLKEMLPQVQFEVSTAADG 417

Human   305 NYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCM 369
            |:|:.:|:|.|.|..::.:|.|:.|||..:.:|||.||..|||.|:.|||||:||.||.:|:||:
 Worm   418 NFLQVVNMSMNSFSMYHSDRRFETTGQQIIFVTPGNGVLHVDRDLVSLTKQRVIDMGISLDMVCL 482

Human   370 GEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFY-TSKSQLFCNSFTPRIKLAGKKPASE 433
            |||||||||||..|......|.:.  :|.||||:|:|:| .::.......|.|||:|    ||:
 Worm   483 GEQPLHAVPLFVFHPIVGQMDKKC--EYFIPHWMNYSYYQMARRSAISVQFRPRIQL----PAA- 540

Human   434 KAKNGRDTSLGSPKE-------SENALPIQV-----DYDA--------------------YDAQV 466
                    .|.:||:       :....|..|     ||||                    .||.|
 Worm   541 --------VLSAPKKMIMGSTGTFRCFPQSVEKYGGDYDAKKLSNVCAKIQLLPKEEANDIDAVV 597

Human   467 FRLPGPSRAQCL----------------TTCRSVRERE------SHSRKSASSCDVSSSPSLP-- 507
            ...|...|.|..                .|..|||||:      |....:..:..::|:|..|
 Worm   598 RDAPEAGRRQLREILGLSPDKVKPNSDDKTKTSVRERKETDGEPSEDNNTQKAAPIASNPPPPPP 662

Human   508 ----------------SRTLPTEEVRSQASDDSSLGKS------ANILMIPHPHLHQYEVSSSLG 550
                            .|.:...::..:.|:.|:.|.|      |..:..|.|......:..:.|
 Worm   663 LPPPPPSVEKKKLEPQDRDIAGSKIIKKNSESSTYGGSVRPVSAAKDIEKPAPQRSLPPLVPNAG 727

Human   551 YTSTRD----------VLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRA--------- 596
            .:|..:          ..|:|..||   ||..|...:||.       |...|..||
 Worm   728 GSSWNNQNRPESPRSASYESMKMPP---SSIGGSIEIGSF-------PAALTKLRATSPSRRGTI 782

Human   597 ----------------------LINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHH-QTRQ 638
                                  |||||.|....:::|:|||||:|.|||..||::...|| .:.|
 Worm   783 DGSTTTLANNDLTAVWKRQNGQLINPFRPEDFAVQVTANRRRWIHVFPVDSSGKSKLAHHFVSGQ 847

Human   639 NMAELQGS-GQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAG 702
            ::..:.|: .::....:.:|:                   ..:..::.|.:.|.....|:.|..|
 Worm   848 SIVHIVGAPDEQKKIVAPSEI-------------------GSVDTVSISKSPEQQSSSLTRSRRG 893

Human   703 MNPRTQNKDSLEDSVSTSPDPILTLSAPPVVPGFCCT----------VGVDWKSLTTPACLPLTT 757
            .|.....|.|   |.|.|..   ..|....|..:..|          :|.|||||...|.||:||
 Worm   894 ANMEDDRKHS---SKSNSAG---NASKKYKVWAWGSTGEEKWNVDMEIGTDWKSLVRSALLPITT 952

Human   758 DYFPDRQGLQ-----------------NDYTEGCY------------DLLP-----EADIDR--- 785
            |:|||.|.||                 .||..|.|            |.|.     .:|:..
 Worm   953 DFFPDGQTLQTQFRMNEYSIEVTNKSLEDYRNGLYEQDECAIIGTPFDSLEMSNSHHSDVQTTLQ 1017

Human   786 -----------RDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKT--QKPNPAVPPPLSSSPLYS 837
                       ||.:.....||.|:|:.|.|||.:||||::..|:  :....|...|.||.|..|
 Worm  1018 TQVKDQRYRRIRDRNEKPTMAQLVYEQLILQRLQRGYQIVLLDKSLVEVSCEAAKKPSSSRPDLS 1082

Human   838 RGLVSRNRPE-----------------EEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQ 885
            |..|:::..|                 :..:..||..:.:||:.|:..::.:|.:.|| ..:|.:
 Worm  1083 RKQVTKSEKERVGSGGSERSRSNPRTIQNPEIVLSFNKFYHKLALEKDVVRITLFRPK-AEKSDE 1146

Human   886 IHYTYSLC--PSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLL 948
            :......|  ||..:.|.:.       |.:..:|.|..|..:.|            :::.|.::.
 Worm  1147 VAGFPGWCERPSMRNEENLD-------EAIRPFKKNAHDDELNS------------RYFNTTYMY 1192

Human   949 ---LPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGF-------VRFVEGLNRIRRR---- 999
               :|...|..|..|:...| |:       |:..|...|..       :.:.|.:......
 Worm  1193 YFQVPDASTYEKSATKLRHH-DL-------DKLNWSAFDSAFKNIFSDILYTESMKCFSASFLVV 1249

Human  1000 -HRSD----RMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQA 1059
             |.:|    :::.|.|..||::...|     .|..:|  .:...|.|:.||.:....:..|
 Worm  1250 FHPTDILKTKLIEKQTEGKGIEFRDP-----KEFESP--NEAWYSRLTKLLLLMNKLQYQG---- 1303

Human  1060 AVHGGKSSAQSAESSSVAMTP---TYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTATPML 1121
                              |.|   :..|..:|       :...|:.     |..:..|...||.:
 Worm  1304 ------------------MVPDPNSLQDRQQK-------WKNKPQN-----YKAIVEDFKKTPYV 1338

Human  1122 DGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKH 1186
                                          |..:||....|                     :.|
 Worm  1339 ------------------------------GLKNTNEKQMS---------------------VAH 1352

Human  1187 PSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEE---QLITHASGEAW 1248
            |:.              .|:..:...||..:||.|....:|:::::::.:.   |:||.:|...:
 Worm  1353 PAN--------------MFVVYDFALWLRYNVEEISKFEIAVNLIRRLADSKFIQVITSSSEGKY 1403

Human  1249 ---------RTF----IYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQRKWFEVAFVA 1300
                     :.|    .|||....|.....|:...:.:.....:...:......:.||
 Worm  1404 GSESSLNSKKMFKFKAEYGFQLCYISDPDFPENSKVSRFMMVEYKNKICQEEETECKW------- 1461

Human  1301 EELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTD 1365
              .:..:|...|.|..|..|..
 Worm  1462 --QLQGDIDMELAPPTPDSPLG------------------------------------------- 1481

Human  1366 RLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYL 1430
              ||....|...|..:.||.|.:.|:..|...:.:.|..|..||:..|..|.||.|.||||....
 Worm  1482 --EWTRITYDHWFYPDTAFRITMKWVMGTGQTVADTVLSWFNKASKQGMSLYPVPEDPFALAQDT 1544

Human  1431 YGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQ----------- 1484
            :.:|||.    |:.|.  |||  :.:..|.|.|        |...|..||||:.
 Worm  1545 HSNPLRC----PIRIQ--LKE--KVVAHSDERE--------FLLKILFRFGFIDIGCNVKHDFSS 1593

Human  1485 ---DKYSASAFNFPAENKP--------------------QYIHVTGTVFLQLPYSKRKFSGQQRR 1526
               |  |:|:.:..|.:.|                    .|||..|.:|:.|..|:
 Worm  1594 PRTD--SSSSDHTKALSSPSPTLQLEGDDGDLDDVTISMNYIHQAGGMFISLVLSE--------- 1647

Human  1527 RRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFW 1591
                  :.|:..|      :.||:|.:|:..:|...:  |||.|.||.:|...|.::::.|...:
 Worm  1648 ------NPNRPPF------FYWAWNHLLSNRYRGQCS--EKFQDYLLSEFRAVCSDKNDTLTQLY 1698

Human  1592 TSC----LEKMHASAP 1603
            :..    |:|...:.|
 Worm  1699 SDFKKEKLQKPRPATP 1714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DEPDC5	NP_001229825.1	IML1	101..381	CDD:463510	124/289 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	427..450		5/29 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..527		11/66 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	696..720		8/23 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1135..1165		4/29 (14%)
		DEP_DEPDC5-like	1179..1260	CDD:239896	17/96 (18%)
		DEPDC5_CTD	1278..1585	CDD:466071	73/340 (21%)
depd-5	NP_001420386.1	IML1	214..493	CDD:463510	123/287 (43%)
		DEP	1336..1424	CDD:214489	21/152 (14%)
		DEPDC5_CTD	<1482..1692	CDD:466071	66/250 (26%)