Protein Alignment DEPDC5 and depdc5

DIOPT Version :10

• Sequence 1: NP_001229825.1
• Gene: DEPDC5 / 9681
• HGNCID: 18423
• Length: 1603
• Species: Homo sapiens
• Sequence 2: XP_004910648.1
• Gene: depdc5 / 100498286
• XenbaseID: XB-GENE-980707
• Length: 1608
• Species: Xenopus tropicalis
• Alignment Length: 1623
• Identity: 1289/1623 - (79%)
• Similarity: 1398/1623 - (86%)
• Gaps: 60/1623 - (3%)

Human     1 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKE 65
            |||.:|||||||||||||||||||:||||||:|.|||||||||||||||||||||||||||||||
 Frog    26 MRTNRVYKLVIHKKGFGGSDDELVINPKVFPYINLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKE 90

Human    66 TISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQ 130
            |:|:||||.|||||||||||||||||||||||||||||||||||||||||||||||||:||||||
 Frog    91 TVSIDQTVAQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSSCAYITQ 155

Human   131 KVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKA 195
            ||||||||||.||||||:|||.||||||||||||||||||||||||||.|:||||||||||||||
 Frog   156 KVEFAGIRAQVGELWVKSEKVTCGYISEDTRVVFRSTSAMVYIFIQMSSELWDFDIYGDLYFEKA 220

Human   196 VNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINR-ASIRQDHKGRFYEDFYKVVV 259
            |||||||||.|||:||||||||||||||||||||::::|||.:| ||:.||||||||||||||||
 Frog   221 VNGFLADLFNKWKDKNCSHEVTVVLFSRTFYDAKNIEDFPEAHRNASVMQDHKGRFYEDFYKVVV 285

Human   260 QNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINR 324
            |||||||||||||||||||||||||||||.|||||.|.||||.||||||||||||||||||||||
 Frog   286 QNERREEWTSLLVTIKKLFIQYPVLVRLENAEGFPPGHNSTSDQGNYLEAINLSFNVFDKHYINR 350

Human   325 NFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPR 389
            |||||||||||||||||||:|||.||||||||||||||||||||||||||||||||||||||:|.
 Frog   351 NFDRTGQMSVVITPGVGVFQVDRSLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSSPG 415

Human   390 DSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESENALP 454
            |||||||||||||||||||||:||...||||||||||.:|..|||.:.|:|.|:|||||:|||||
 Frog   416 DSRLGDDYNIPHWINHSFYTSQSQPLNNSFTPRIKLAPRKTNSEKGRTGKDPSIGSPKETENALP 480

Human   455 IQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQ 519
            |||||||||:||||||||||||...|.|:|  ||:..|||:.|.|.|.||  .||....||.|||
 Frog   481 IQVDYDAYDSQVFRLPGPSRAQRSITFRAV--RETQVRKSSCSYDTSCSP--VSRPFTAEEGRSQ 541

Human   520 ASDDSSLGKSANILMIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESML 584
            .||:|||||.:|||:||.|||||||.|||||||||||.||.|:|..|||||||||||||||||||
 Frog   542 NSDESSLGKLSNILLIPRPHLHQYEASSSLGYTSTRDFLERMIESQQRDSSAPGRFHVGSAESML 606

Human   585 HVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQR 649
            |||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
 Frog   607 HVRPGGYHPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGMR 671

Human   650 DPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELS----VGLLSNSGAGMNPRTQNK 710
            :.:||||||||||||||.||||..|.||:..|   ....||.|    :....|...|.|.|  .|
 Frog   672 EASHSSAELLELAYHEATGRHSGPRTPGENGS---CGSNEEFSCNTPINGQRNHNTGSNHR--EK 731

Human   711 DSLEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCY 775
            :|.:|||...|:|||.||||||||||||||||||||||||||||||||||||||.||||||||||
 Frog   732 ESSDDSVPCCPEPILMLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQSLQNDYTEGCY 796

Human   776 DLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGL 840
            |||||||:|||||:|.|||||||||||||||||||||||||||..|...:|||||||||||.|||
 Frog   797 DLLPEADLDRRDEEGAQMTAQQVFEEFICQRLMQGYQIIVQPKHPKAISSVPPPLSSSPLYRRGL 861

Human   841 VSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCW 905
            |||||.|||:||||||||||||||||||:|||||||||||||||||.|.||||||||:.:|||.|
 Frog   862 VSRNRAEEENQYWLSMGRTFHKVTLKDKIITVTRYLPKYPYESAQISYMYSLCPSHSECDFVSSW 926

Human   906 VEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYG 970
            |||||||||:|||||||||||||||||||||||||||||||||||:||..||||||||..|||||
 Frog   927 VEFSHERLEDYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPSCVGPTKRITEGEQRCDIYG 991

Human   971 DRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGK 1035
            :|||::::|.||||||:||||||||||||||||||:|||..|||||    :.:|..|...||:||
 Frog   992 ERPRSEQEEAQLLDGFLRFVEGLNRIRRRHRSDRMIRKGAGMKGLQ----LPSHPPEPPGPPIGK 1052

Human  1036 KGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKDGAFFMEFVRSP 1100
            ||||||||||||||:||.||||||.||..|.|:|   .|..|:||||:||||||||||:||||||
 Frog  1053 KGTSALSALLEMEANQKSLGEQQALVHAAKLSSQ---VSDPAVTPTYVDSPRKDGAFFVEFVRSP 1114

Human  1101 RTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGN--------SQNIGEQGYSSTN 1157
            |||.| |.||:|:||       ||||             .|.||        |:.|..||.:|.:
 Frog  1115 RTAPS-FTPQISIDQ-------GTSL-------------VTDGNNAMPNPTPSERIQSQGATSVD 1158

Human  1158 ----SSDSSSQQLVA--SSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVN 1216
                |::.|:||:..  |.|.::::|:|||||||||:||:.||||||.|.|.||||||.||||||
 Frog  1159 QPPTSTECSAQQISVGPSVLPTTASLSEILEAMKHPTTGIPLLSEQKCLPPGCFISAEAVHWLVN 1223

Human  1217 HVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVA-MQQPATTWHT 1280
            ::..:|:|.||:||||||||||.|||||||.:||||||||.|||..||||||.: :.||. .||:
 Frog  1224 NISWVQSQVMAMDIMQKMLEEQYITHASGETFRTFIYGFYLYKIPADKEPDRASNLVQPC-VWHS 1287

Human  1281 AGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLA 1345
            ..::||.:|||||||||.|.|||:|||||.|||||||||||||||||||||||||||||||||||
 Frog  1288 TAMEDFTAFQRKWFEVALVEEELLHSEIPPFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLA 1352

Human  1346 ATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKAT 1410
            ||||||||||||||||||||||||||.||||||||.|||||||||||.|||:||||||||||||.
 Frog  1353 ATVPEQRTVTLDVDVNNRTDRLEWCSSYYHGNFSLTAAFEIKLHWMAATAAMLFEMVQGWHRKAP 1417

Human  1411 SCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEA 1475
            |||||||||:||||:|||||||||||||||||||||||:|..::|||:.|||||||:||:|.||.
 Frog  1418 SCGFLLVPVVEGPFSLPSYLYGDPLRAQLFIPLNISCLVKAENDHLFEGFEPETYWERMYLLQEV 1482

Human  1476 IAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFC 1540
            ||:||||:||||||||||||:|||||||||||||||||||||||  ||||||||||||:.||:|.
 Frog  1483 IAYRFGFIQDKYSASAFNFPSENKPQYIHVTGTVFLQLPYSKRK--GQQRRRRNSTSSSTQNLFG 1545

Human  1541 EERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFWTSCLEKMHASAP 1603
            |||:||||||||||||||||..||||:|||||||||||||.||||||.|||.:|||||:.|||
 Frog  1546 EERIGYNWAYNTMLTKTWRSIGTGDERFADRLLKDFTDFCANRDNRLGTFWANCLEKMNTSAP 1608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DEPDC5	NP_001229825.1	IML1	101..381	CDD:463510	257/280 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	427..450		12/22 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..527		22/42 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	696..720		9/23 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1135..1165		10/41 (24%)
		DEP_DEPDC5-like	1179..1260	CDD:239896	61/80 (76%)
		DEPDC5_CTD	1278..1585	CDD:466071	263/306 (86%)
depdc5	XP_004910648.1	IML1	126..407	CDD:463510	257/280 (92%)
		DEP_DEPDC5-like	1184..1267	CDD:239896	62/82 (76%)
		DEPDC5_CTD	1285..1590	CDD:466071	263/306 (86%)