Protein Alignment PDE4DIP and cnn

DIOPT Version :10

• Sequence 1: NP_001382226.1
• Gene: PDE4DIP / 9659
• HGNCID: 15580
• Length: 2525
• Species: Homo sapiens
• Sequence 2: NP_001246293.1
• Gene: cnn / 36491
• FlyBaseID: FBgn0013765
• Length: 1378
• Species: Drosophila melanogaster
• Alignment Length: 1828
• Identity: 352/1828 - (19%)
• Similarity: 634/1828 - (34%)
• Gaps: 567/1828 - (31%)

Human   783 LQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAA------AEKLVQALMERNSELQ 841
            :.:.:::|:|...|.|........||. |:::|::..:|:.||      ..||.:||.:...:
  Fly     1 MDQSKQVLRDYCGDGNGTCASSLKEIT-LIETVTSFLEENGAAEIDRRVLRKLAEALSKSIDD-- 62

Human   842 ALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLG 906
                                              |..|::|     |.|...:.....:||...|
  Fly    63 ----------------------------------TSPGALQ-----DVTMENSYASFDVPRPPGG 88

Human   907 DLD-------TVAGLEKELSNAKEE---LELMAKKERESQMELSALQSMMAVQEEELQVQAADME 961
            ...       :|..||:::|..::|   |:|......|.|....|..|..::.::.:..: .::.
  Fly    89 GNSPLPSQGRSVRELEEQMSALRKENFNLKLRIYFLEEGQPGARADSSTESLSKQLIDAK-IEIA 152

Human   962 SLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLL--LREKVAS---VESQGQEISGNRRQQ 1021
            :|.:.:.:|.:|:||....:...|::.....:..:.::  |:|::.:   .||.||.:....:.:
  Fly   153 TLRKTVDVKMELLKDAARAISHHEELQRKADIDSQAIIDELQEQIHAYQMAESGGQPVENIAKTR 217

Human  1022 LLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQV-LRSRLEEVLG 1085
            .:|.||   .|..||.|.|                           |.:|...| .|:.||.:|.
  Fly   218 KMLRLE---SEVQRLEEEL---------------------------VNIEARNVAARNELEFMLA 252

Human  1086 RSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPS 1150
                  .|||:|.|..|                .|:|.|..:|  :||: .|||..|:.|:.|.:
  Fly   253 ------ERLESLTACEG----------------KIQELAIKNS--ELVE-RLEKETASAESSNEA 292

Human  1151 FSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEEL--------KELKAQIEEAGFSSVSH 1207
            .        ||          |:.|    ||..||..::|        .::|.|:.     |:..
  Fly   293 I--------DS----------LKVE----LEACRKENQDLVTSIRTLKHDMKRQVR-----SMKE 330

Human  1208 IRNTM----LSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKL 1268
            ..|||    .|:.|..|.:|             .::|..|. |.:.|:..|.|. :.|.||...:
  Fly   331 AANTMDVQRQSILLLEATIK-------------RKEKSCGS-MQKNVLNYEALI-AKLNAELETM 380

Human  1269 QGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTV 1333
            :.:......:...|:::.|.....|.:.:.|              ..:....|:...|....|..
  Fly   381 RQQNVYFRELSENLQQKEVRQLDRGVAIVQP--------------MRMTADAGRFVWQSGTIVAQ 431

Human  1334 RPFP-RPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAF-------------------SLPGSTQH 1378
            .|.| ..||....:..:|.|.:|.:...|....|.:..                   ::|.:..|
  Fly   432 EPLPLERQSAAATSNVSVSAVRLSSGPPPDQTYPVNGHDRAKYGLLQLFAAKLDWISAVPLALGH 496

Human  1379 -------LRSQLSQCKQRY-------QDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSK 1429
                   |..:|..|.|..       :||..: |..:.....:|.|..|.|     |.:.:|..:
  Fly   497 LALKIILLAMRLHSCLQNVHIPLRANRDLGAQ-LADKICELQEAQEKLKER-----ERIHEQACR 555

Human  1430 QIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKP 1494
            .||..:|.|..:.....:...|.|::.:.|    |...:.|:..   |..||..|...:||:.
  Fly   556 TIQKLMQKLSSQEKEIKKLNQENEQSANKE----NDCAKTVISP---SSSGRSMSDNEASSQE-- 611

Human  1495 LENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQN-ANKVIQNLKSRVRSLSVTSDYSSSLERP 1558
            :...|..:.|.::..:.|.|..|:.::|...|.||| .||.:.. |:|            .:||.
  Fly   612 MSTNLRVRYELKINEQEEKIKQLQTEVKKKTANLQNLVNKELWE-KNR------------EVERL 663

Human  1559 RKLRA--VGTLEGSSPHSVPDEDEGWLSDG-TGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGL 1620
            .||.|  ..||...|..|..:.|   |... |.|.|...|:..|    |:||...:        |
  Fly   664 TKLLANQQKTLPQISEESAGEAD---LQQSFTEAEYMRALERNK----LLQRKVDV--------L 713

Human  1621 EEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDI 1685
            .::||::.::::..|:....:|....|:....:...|...:|.::|...::.......||:..|:
  Fly   714 FQRLADDQQNSAVIGQLRLELQQARTEVETADKWRLECVDVCSVLTNRLEELAGFLNSLLKHKDV 778

Human  1686 DYYLG-------QSFREQLAQGSQLTERLTSKLS-TKDHKSEKDQAGLEPLALRLSRELQEKEKV 1742
               ||       .:.|:.:.:...|::.|...|: |....:::..|.|..|:
  Fly   779 ---LGVLAADRRNAMRKAVDRSLDLSKSLNMTLNITATSLADQSLAQLCNLS------------- 827

Human  1743 IEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDS 1807
             |:|..:.||       ||...:||          :||.|.:.|....|....|.|
  Fly   828 -EILYTEGDA-------SHKTFNSH----------EELHAATSMAPTVENLKAENK--------- 865

Human  1808 IHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQA 1872
                    .|..:.....:|:|.:.|..|.|  ||:.|...:..::|.|     ...:..||.:.
  Fly   866 --------ALKKELEKRRSSEGQRKERRSLP--LPSQQFDNQSESEAWS-----EPDRKVSLARI 915

Human  1873 PLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQE----------------LQMLQKQLGESAS 1921
            .|....:|.              ..|..:::|::.|                :..|::|:.:...
  Fly   916 GLDETSNSL--------------AAPEQAISESESEGRTCATRQDRNRNSERIAQLEEQIAQKDE 966

Human  1922 TVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSG 1986
            .:     ..:....:|.|:.|.....:       .:::.:.||.           :|....:::.
  Fly   967 RM-----LNVQCQMVELDNRYKQEQLR-------CLDITQQLEQ-----------LRAINEALTA 1008

Human  1987 DLSS-GSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTS 2050
            ||.: ||..             ||.:.|::...:...:.|   |:|:  |.|. |.||
  Fly  1009 DLHAIGSHE-------------EERMVELQRQLELKNQQI---DQLK--LAHS-TLTA------- 1047

Human  2051 NFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSR-SHLQELEKELE 2114
                           ::::...:.:.||.|:..:.:.|:...|:|:..|...: ..:|:||   |
  Fly  1048 ---------------DSQITEMELQALQQQMQEIEQLHADSVETLQSQLQKLKLDAVQQLE---E 1094

Human  2115 HQKVERQQLLED------LREKQQEVLHFREERLSLQENDSRLQHKLV-------LLQQQCEEKQ 2166
            |:::.|:.|..|      .:|:.|::|..:......|||:..|:..||       .|::|.:|
  Fly  1095 HERLHREALERDWVALTTYQEQAQQLLELQRSLDYHQENEKELKQTLVENELATRALKKQLDE-- 1157

Human  2167 QLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCL 2231
               .:||:...:.|.        .|||           :|...|......||.|||       .|
  Fly  1158 ---STLQASKAVMER--------TKAY-----------NDKLQLEKRSEELRLQLE-------AL 1193

Human  2232 RLQLQQQLESGAGKASLSPSSINQNFPA--STDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSS 2294
            :.:.|:.|:..:..:.:|.|.......|  ...|..:....:.:|.:...:.|..:||.|...|.
  Fly  1194 KEEHQKLLQKRSNSSDVSQSGYTSEEVAVPMGPPSGQATTCKQAAAAVLGQRVNTSSPDLGIESD 1258

Human  2295 ASSTPGSETPIINRANGLGLDTSPVMKT-PPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIA 2358
            |......|.....||         ::|| ..|.||.|:.
  Fly  1259 AGRISSVEVSNAQRA---------MLKTVEMKTEGSASP-------------------------- 1288

Human  2359 EGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALP 2423
                                  :|:..|.........:.:..:.:|...:
  Fly  1289 ----------------------KAKSEESTSPDSKSNVATGAATVHDCAK--------------- 1316

Human  2424 STHIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVL 2488
                          .:.|..|||.|:.:.:|..:.|.|.|:.||:.|..:|:.|.:|:.:||:||
  Fly  1317 --------------VDLENAELRRKLIRTKRAFEDTYEKLRMANKAKAQVEKDIKNQILKTHNVL 1367

Human  2489 KKARTNLE 2496
            :..|:|:|
  Fly  1368 RNVRSNME 1375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE4DIP	NP_001382226.1	SMYLE_N	1..376	CDD:465822
		SMC_prok_B	403..1201	CDD:274008	90/447 (20%)
		Olduvai	1715..1784	CDD:429104	14/68 (21%)
		Smc	<2004..>2181	CDD:440809	40/190 (21%)
cnn	NP_001246293.1	Cnn_1N	101..170	CDD:462333	15/69 (22%)
		Smc	<138..>404	CDD:440809	75/363 (21%)
		SMC_prok_B	498..1200	CDD:274008	181/914 (20%)
		Smc	<929..>1247	CDD:440809	73/415 (18%)