Protein Alignment SOCS5 and Socs5

DIOPT Version :10

• Sequence 1: NP_054730.1
• Gene: SOCS5 / 9655
• HGNCID: 16852
• Length: 536
• Species: Homo sapiens
• Sequence 2: NP_062628.2
• Gene: Socs5 / 56468
• MGIID: 2385459
• Length: 536
• Species: Mus musculus
• Alignment Length: 536
• Identity: 506/536 - (94%)
• Similarity: 520/536 - (97%)
• Gaps: 0/536 - (0%)

Human     1 MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLRENIAL 65
            ||||||||||.||||||||.||||||:|||:||.|||.|||||:||:|::.|||:|||||||:||
Mouse     1 MDKVGKMWNNLKYRCQNLFSHEGGSRNENVEMNPNRCPSVKEKSISLGEAAPQQESSPLRENVAL 65

Human    66 QLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCST 130
            ||||||||..||||||||.||||:||||||||:||..||||||||||||||||||||||||||||
Mouse    66 QLGLSPSKTFSRRNQNCAAEIPQVVEISIEKDSDSGATPGTRLARRDSYSRHAPWGGKKKHSCST 130

Human   131 KTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTYS 195
            |||||||.:|||||||||||||||||||||:.||||||||.||||||||||||||||||||||||
Mouse   131 KTQSSLDTEKKFGRTRSGLQRRERRYGVSSMQDMDSVSSRAVGSRSLRQRLQDTVGLCFPMRTYS 195

Human   196 KQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDE 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 KQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDE 260

Human   261 EDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSE 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||.|||||
Mouse   261 EDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDGSAIPQTNCDSE 325

Human   326 EDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYE 390
            ||:||||||||||||||:|||||.|||||||||||||||||||||||||||||||||||||||||
Mouse   326 EDSTTLCLQSRRQKQRQVSGDSHAHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYE 390

Human   391 AEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGL 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 AEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGL 455

Human   456 LEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYK 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 LEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYK 520

Human   521 QKVRVRWLEREPVKAK 536
            ||||||||||||||||
Mouse   521 QKVRVRWLEREPVKAK 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOCS5	NP_054730.1	Required for interaction with IL4R. /evidence=ECO:0000250	1..50		40/48 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..175		54/59 (92%)
		SOCS	145..195	CDD:432667	46/49 (94%)
		SH2	370..470	CDD:472789	99/99 (100%)
		SOCS_SOCS5	479..534	CDD:239708	54/54 (100%)
Socs5	NP_062628.2	Required for interaction with IL4R	1..50		40/48 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..59		26/36 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..175		71/79 (90%)
		SOCS	145..195	CDD:432667	46/49 (94%)
		SH2	370..470	CDD:472789	99/99 (100%)
		SOCS_SOCS5	479..534	CDD:239708	54/54 (100%)