Protein Alignment SOCS5 and socs5b

DIOPT Version :10

• Sequence 1: NP_054730.1
• Gene: SOCS5 / 9655
• HGNCID: 16852
• Length: 536
• Species: Homo sapiens
• Sequence 2: XP_005156658.2
• Gene: socs5b / 559639
• ZFINID: ZDB-GENE-080722-18
• Length: 598
• Species: Danio rerio
• Alignment Length: 575
• Identity: 373/575 - (64%)
• Similarity: 426/575 - (74%)
• Gaps: 60/575 - (10%)

Human     1 MDKVGKMWNNFKYRCQNLFGHEGGSRSE--NVDMNSNRCL-----SVKEKNISIGDSTPQQQSSP 58
            ::.|||||.|.:.|||.|| |..||.|.  :.|::...|:     ....:......|||.:..||
Zfish    36 VENVGKMWGNLRSRCQALF-HSDGSESHLCSQDLDCAHCVLDLDRGAHAEPYETRSSTPSRNLSP 99

Human    59 LRENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDN-DSCVTPGTRLARRDSYSRHAPWGG 122
            |           |.....||:.||..:|||||||||:|:: |:...|   |.|||||||||||||
Zfish   100 L-----------PLATGGRRSHNCVADIPQIVEISIDKESEDARRGP---LVRRDSYSRHAPWGG 150

Human   123 KKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDM-DSV----SSRTVGSRSLRQRLQ 182
            ||||||||||||||:||::.||:|....||||||.|||:.:: |||    |.|::.||||||||:
Zfish   151 KKKHSCSTKTQSSLEADRRTGRSRGSTARRERRYAVSSIQEINDSVEVGSSGRSLSSRSLRQRLR 215

Human   183 DTVGLCFPMRTY--SKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHST 245
            ||||||.|:.|:  |:.:|...|:||||||:|||||.||||.|||||.||||||||||||||||:
Zfish   216 DTVGLCLPLPTHRRSQSAKGQVSSKRKIHLTELMLETCPFPPGSDLANKWHLIKQHTAPVSPHSS 280

Human   246 --FFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMT 308
              .||.||.:..|.||||:||||||||||||||||||||||||.|||::.:.|||||||:|||:.
Zfish   281 SALFDAFDSAHSSPEDEEERLRERRRLSIEEGVDPPPNAQIHTLEATSKSSSLYKLGPKMAPGVG 345

Human   309 EISGD-----------------------SSAIPQ--ANCDSEEDTTTLCLQSRRQKQRQISGDSH 348
            |..|:                       |.|:|.  .:||||||:||||||:||.|||..|||
Zfish   346 ETLGEGRSLGTVSSISGGLSGIAAQVPTSMAVPSHTVDCDSEEDSTTLCLQTRRPKQRHASGD-- 408

Human   349 THVSRQ-GAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQED 412
            ||.||| |.|||||||||||||||||..||..||||||||||:|||||:|:||||||||||||||
Zfish   409 THCSRQPGPWKVHTQIDYIHCLVPDLQAITALPCYWGVMDRYQAEALLDGRPEGTFLLRDSAQED 473

Human   413 YLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLN 477
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||..|:
Zfish   474 YLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSACMFFEPLLTAPLH 538

Human   478 RTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREP 532
            ||||||||::.|:.|||.||||||..||||..:||||||||||||||||||||||
Zfish   539 RTFPFSLQHLARSSICRHTTYDGIGALPLPPTMQDFLKEYHYKQKVRVRWLEREP 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOCS5	NP_054730.1	Required for interaction with IL4R. /evidence=ECO:0000250	1..50		17/55 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..175		41/64 (64%)
		SOCS	145..195	CDD:432667	31/56 (55%)
		SH2	370..470	CDD:472789	91/99 (92%)
		SOCS_SOCS5	479..534	CDD:239708	43/54 (80%)
socs5b	XP_005156658.2	None