Protein Alignment SOCS5 and socs5

DIOPT Version :10

• Sequence 1: NP_054730.1
• Gene: SOCS5 / 9655
• HGNCID: 16852
• Length: 536
• Species: Homo sapiens
• Sequence 2: NP_001016844.1
• Gene: socs5 / 549598
• XenbaseID: XB-GENE-479593
• Length: 535
• Species: Xenopus tropicalis
• Alignment Length: 537
• Identity: 433/537 - (80%)
• Similarity: 483/537 - (89%)
• Gaps: 3/537 - (0%)

Human     1 MDKVGKMWNNFKYRCQNLFGHEG-GSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLRENIA 64
            ||||.||||.|||||||||.|:. .::::.||:|:||||...:||.:....:......||::||.
 Frog     1 MDKVEKMWNTFKYRCQNLFSHDDEANQNDTVDVNANRCLGGIDKNENASGQSAMLSIGPLQQNIT 65

Human    65 LQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCS 129
            .:  ||||.:||||||||.:|:||:||||:|:||||.::.||||||||||:||||||||||||||
 Frog    66 SE--LSPSSSSSRRNQNCVSEMPQLVEISVERDNDSGLSAGTRLARRDSYTRHAPWGGKKKHSCS 128

Human   130 TKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTY 194
            ||||:|.|.|||..||||||||||||:|.:|||||:::.||.||||||||||.:|||||||:|||
 Frog   129 TKTQNSFDPDKKICRTRSGLQRRERRHGANSVHDMETIGSRAVGSRSLRQRLNETVGLCFPIRTY 193

Human   195 SKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTED 259
            ::.|||||:||||||||||||||||||.||||||||||||||||||||||:|.:|||.|:||.||
 Frog   194 NRPSKPLFTNKRKIHLSELMLEKCPFPPGSDLAQKWHLIKQHTAPVSPHSSFLETFDQSVVSAED 258

Human   260 EEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDS 324
            ||||||||||||||||||||||||||||||||||||:|||||||||||.:||||.:|:.|..|:|
 Frog   259 EEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPVYKLGPKLAPGMADISGDVNAVCQGGCES 323

Human   325 EEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRY 389
            ||||||||||||||||||.||||||.:::||||||||||||||||||||::|..|||||||||||
 Frog   324 EEDTTTLCLQSRRQKQRQFSGDSHTQITKQGAWKVHTQIDYIHCLVPDLIEIISNPCYWGVMDRY 388

Human   390 EAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTG 454
            ||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   389 EAEALLEGRPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTG 453

Human   455 LLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHY 519
            |||||||||||||||||||:.|||||||||||||||||||.|||||||.||||||||||||||||
 Frog   454 LLEHYKDPSSCMFFEPLLTVPLNRTFPFSLQYICRAVICRSTTYDGIDLLPLPSMLQDFLKEYHY 518

Human   520 KQKVRVRWLEREPVKAK 536
            |||||||||||||:|:|
 Frog   519 KQKVRVRWLEREPIKSK 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOCS5	NP_054730.1	Required for interaction with IL4R. /evidence=ECO:0000250	1..50		27/49 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..175		45/59 (76%)
		SOCS	145..195	CDD:432667	38/49 (78%)
		SH2	370..470	CDD:472789	94/99 (95%)
		SOCS_SOCS5	479..534	CDD:239708	52/54 (96%)
socs5	NP_001016844.1	SOCS	144..195	CDD:432667	39/50 (78%)
		SH2	369..469	CDD:472789	94/99 (95%)
		SOCS	478..534	CDD:470605	52/55 (95%)