Protein Alignment SOCS5 and Socs36E

DIOPT Version :10

• Sequence 1: NP_054730.1
• Gene: SOCS5 / 9655
• HGNCID: 16852
• Length: 536
• Species: Homo sapiens
• Sequence 2: NP_523593.5
• Gene: Socs36E / 35085
• FlyBaseID: FBgn0041184
• Length: 737
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 176/530 - (33%)
• Similarity: 248/530 - (46%)
• Gaps: 103/530 - (19%)

Human    50 STPQ---QQSSPLREN-IALQLGLSPS----KNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGT 106
            |:|:   .:..|:..| :|..:|.:.|    .::...|.||..|         ..|:|.......
  Fly   148 SSPEAAKTERQPVNNNGLAGSVGAAISTLQLHDNHGGNANCPLE---------ADDDDDLDESLL 203

Human   107 RLARRDSYSR--------HAPWGGKKKHSC------------------STKTQSSLDADKKFGRT 145
            |..|.:|.||        |.....:::|..                  |..||.|.....:...:
  Fly   204 RRRRSNSNSRSNIHHHHHHHQQQQQQQHEAEVVEYCEVLESLPVSNMLSAGTQHSSKPVSRSNNS 268

Human   146 RSGLQRRERR---YGVSSVHDMDSVSSRTVGSRSLRQR-----LQDTV-GLCFPMRTYSKQSKPL 201
            .|..:.|..:   .|.::.....|.|:....|.|.::|     .:|.: ||    |.....|...
  Fly   269 NSCCRSRSSKALSMGAATSSASGSASTSVSTSTSSKRRCCKCKCRDAIRGL----RDMLPSSSSS 329

Human   202 FSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRE 266
            .|||:                  |.|....::.:.:......||     .|:|.::.....|..:
  Fly   330 VSNKK------------------DAAAVVAMVPRKSRTADRRST-----PPTLGTSSGGSQRRMQ 371

Human   267 RRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTTTL 331
            .:|:.....|   |:|..|..:...::.         :||....|.:...:......:.:...|
  Fly   372 SQRIRNSVAV---PDASHHHHQLIIRIT---------SPGFVVESPNGGRVTVVTEPAPQSPQT- 423

Human   332 CLQSRRQKQRQIS------GDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYE 390
                 ..:.|.::      |..|..:.......||:|||::|||||||.:||.:..|||.|||||
  Fly   424 -----PPRPRPLATVAPAGGAGHAGIGAARNMTVHSQIDFMHCLVPDLEKITNSSFYWGKMDRYE 483

Human   391 AEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGL 455
            ||.||||||||||||||||||::||||:||:|.|||||||||..|.||||.||||||.:.|||||
  Fly   484 AEHLLEGKPEGTFLLRDSAQEEFLFSVTFRKYGRSLHARIEQSGHKFSFDCHDPCVFTAPTVTGL 548

Human   456 LEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYK 520
            |||||||:..|||||.|||.|:|...||||.:.||.|...|:||||:.:.||..|:.:|||||||
  Fly   549 LEHYKDPACVMFFEPCLTIPLHRRQTFSLQQLSRATIVSNTSYDGINQMELPGRLKSYLKEYHYK 613

Human   521 QKVRVRWLER 530
            ||:||:.:::
  Fly   614 QKLRVKPIDQ 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOCS5	NP_054730.1	Required for interaction with IL4R. /evidence=ECO:0000250	1..50		176/530 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..175		13/88 (15%)
		SOCS	145..195	CDD:432667	12/58 (21%)
		SH2	370..470	CDD:472789	76/99 (77%)
		SOCS_SOCS5	479..534	CDD:239708	26/52 (50%)
Socs36E	NP_523593.5	SH2	463..563	CDD:472789	76/99 (77%)
		SOCS	575..626	CDD:470605	26/49 (53%)