DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SOCS5 and Socs16D

DIOPT Version :9

Sequence 1:	NP_054730.1	Gene:	SOCS5 / 9655	HGNCID:	16852	Length:	536	Species:	Homo sapiens
Sequence 2:	NP_001259662.1	Gene:	Socs16D / 32760	FlyBaseID:	FBgn0030869	Length:	1021	Species:	Drosophila melanogaster

Alignment Length:	316	Identity:	81/316 - (25%)
Similarity:	121/316 - (38%)	Gaps:	85/316 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   237 TAPVSP-------------HSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFE 288
            |||:.|             .:......:.:|::.|.:|                  |||.:....
  Fly   747 TAPLIPPIAVITSAPGAAGQTQLASELNGTLITAEADE------------------PNADLRKKF 793

Human   289 ATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSR 353
            .:..:.||    ||.|...|   ..:.||.....:.||..|...     |:.|.:...|.....:
  Fly   794 QSRALPPL----PKKALPFT---AAAYAIEAVKSEPEEVKTNAI-----QEPRALQFTSSIEKVK 846

Human   354 QGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVS 418
            ...|                        |||.:....||.:|..:|:|:|::|||:.:.|:||:|
  Fly   847 DYGW------------------------YWGPLSSEAAEKVLSSEPDGSFIVRDSSDDHYIFSLS 887

Human   419 FRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSC---MFF-------EPLLT 473
            |:..|...|.||||....|||.::  ..|.|.|:|..:|...:.|..   :||       .|:..
  Fly   888 FKLNNCVRHVRIEQDQGTFSFGSY--AKFKSQTITEFIEKAVEHSRSGRYLFFLHRRPEHGPMRV 950

Human   474 ISLNRTFPF----SLQYICRAVICRCT-TYDGIDGLPLPSMLQDFLKEYH-YKQKV 523
            ...|....|    |||::||.||.:.. ..|.|..||||..|.|:|...| |.::|
  Fly   951 QLTNPVSRFKHVQSLQHMCRFVILKAVIRKDLIQTLPLPRRLLDYLNYKHCYSEQV 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SOCS5	NP_054730.1	Required for interaction with IL4R. /evidence=ECO:0000250	1..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..175
		SOCS	146..195	CDD:403716
		SH2	370..470	CDD:417686	34/109 (31%)
		SOCS_SOCS5	479..534	CDD:239708	20/51 (39%)
Socs16D	NP_001259662.1	SH2_SOCS7	839..937	CDD:198251	34/123 (28%)
Socs16D	NP_001259662.1	SOCS_SOCS7	960..1009	CDD:239710	19/47 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810