DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PPM1F and Pp2C1

DIOPT Version :9

Sequence 1:	NP_055449.1	Gene:	PPM1F / 9647	HGNCID:	19388	Length:	454	Species:	Homo sapiens
Sequence 2:	NP_001284867.1	Gene:	Pp2C1 / 31404	FlyBaseID:	FBgn0022768	Length:	1427	Species:	Drosophila melanogaster

Alignment Length:	348	Identity:	89/348 - (25%)
Similarity:	140/348 - (40%)	Gaps:	70/348 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   166 RRKMEDRHVSLPSFNQLFGLSDPVNR----AYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTD 226
            |:.|||:      |:..:..| |:..    |:|.::|||||.:||.:|..|:.....:|.:..:|
  Fly   267 RKYMEDQ------FSVAYQES-PITHELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQFWSD 324

Human   227 PE----GALRE-------AFRRTDQMFLRKAKRERLQSGTTGVCALIAGATLHVAWLGDSQVILV 280
            .:    .|:||       |..|..:.:.|.|......:|||...|.:....:::..:|||.::|.
  Fly   325 QDEDVLRAIREGYIATHFAMWREQEKWPRTANGHLSTAGTTATVAFMRREKIYIGHVGDSGIVLG 389

Human   281 QQGQVVK------LMEPHRPERQDEKARIEALGGFVS-----------------HMDCWRVNGT- 321
            .|.:..:      |...|:||...||.||:..||.|:                 |....|....
  Fly   390 YQNKGERNWRARPLTTDHKPESLAEKTRIQRSGGNVAIKSGVPRVVWNRPRDPMHRGPIRRRTLV 454

Human   322 -----LAVSRAIGDV------FQKPYVSGEADAASRALTGSE-DYLLLACDGFFDVVPHQEVVGL 374
                 |||:|::||:      |::..||.:.|.....:..|. ..|:...||.::||..||.|..
  Fly   455 DEIPFLAVARSLGDLWSYNSRFKEFVVSPDPDVKVVKINPSTFRCLIFGTDGLWNVVTAQEAVDS 519

Human   375 V-QSHLTRQ--------QGSGLRVAEELVAAARERGSHDNITVMVVFLRDPQELLEGGNQGEGDP 430
            | :.||..:        ..|...|.:.|...|.::...||.:|:.|.| .|.............|
  Fly   520 VRKEHLIGEILNEQDVMNPSKALVDQALKTWAAKKMRADNTSVVTVIL-TPAARNNSPTTPTRSP 583

Human   431 QAEGRRQDLPSS--LPEPETQAP 451
            .|..|..||...  |.|.:.:.|
  Fly   584 SAMARDNDLEVELLLEEDDEELP 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PPM1F	NP_055449.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		PP2C	155..406	CDD:278884	76/299 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..454		8/35 (23%)
Pp2C1	NP_001284867.1	PP2Cc	256..567	CDD:238083	79/306 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810