DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTR9 and Ctr9

DIOPT Version :9

Sequence 1:	NP_055448.1	Gene:	CTR9 / 9646	HGNCID:	16850	Length:	1173	Species:	Homo sapiens
Sequence 2:	NP_788448.1	Gene:	Ctr9 / 38149	FlyBaseID:	FBgn0035205	Length:	1150	Species:	Drosophila melanogaster

Alignment Length:	1170	Identity:	680/1170 - (58%)
Similarity:	846/1170 - (72%)	Gaps:	41/1170 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     6 IEIPLRDTDEVIELDFDQLPEGDEVISILKQEHTQLHIWIALALEYYKQGKTEEFVKLLEAARI- 69
            |||||:|||||||:|.||||:..||:||||||...||:|:.:||.||||.|||:||.|||.:|.
  Fly     5 IEIPLQDTDEVIEVDPDQLPDCPEVLSILKQERAPLHVWVNVALAYYKQKKTEDFVTLLEESRSD 69

Human    70 DGNLDYRDHEKDQMTCLDTLAAYYVQQARKEKNKDNKKDLITQATLLYTMADKIIMYDQNHLLGR 134
            |...:|||.:||.|..||.|||:|||:|.:||:||.|::|..:||.|||.|||||||||:|||||
  Fly    70 DATKEYRDSDKDLMRALDMLAAHYVQEAYREKSKDKKRELFMKATNLYTSADKIIMYDQSHLLGR 134

Human   135 ACFCLLEGDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAE 199
            |.||||||||||||||||:|||||||:|||:|||||||:||:||||||:|:|||||||||.|||.
  Fly   135 AYFCLLEGDKMDQADAQFNFVLNQSPSNIPSLLGKACIAFNRKDYRGAMAFYKKALRTNPNCPAN 199

Human   200 VRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTI 264
            ||:||.|||:|:...|||:|||.|||:|:.:|||||:|||||:||..|.:|.|.|||:||:||||
  Fly   200 VRIGMAHCFLKMGNPEKAKLAFERALQLDQQCVGALIGLAVLKLNQLEPESNKLGVQMLSKAYTI 264

Human   265 DPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYY 329
            |.:||||||||||||||||||.||.|||||||||||.|||:||||||||||||.|.|||||||||
  Fly   265 DNANPMVLNHLANHFFFKKDYQKVHHLALHAFHNTENEAMRAESCYQLARSFHAQSDYDQAFQYY 329

Human   330 YQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKR 394
            ||:||.|.::||||.:|||||||||||.|||:||||||||..|.|||||||||||||.|..|.||
  Fly   330 YQSTQIAPANFVLPHYGLGQMYIYRGDTENAAQCFEKVLKIQPGNYETMKILGSLYAHSNSQTKR 394

Human   395 DIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGA 459
            |:||.||||||||:|:|:||||||||||||.|:|.:|||||||:.||::|.:.::|.||.|||.:
  Fly   395 DMAKTHLKKVTEQFPEDIEAWIELAQILEQNDLQASLSAYGTASSILRDKAKYEIPAEIQNNVAS 459

Human   460 LHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNIL 524
            ||:|||||..||....::|..|.:|.:.|..||.:|.||..||||||.|||..:..|:||||.||
  Fly   460 LHYRLGNLKMAKLTLESALKHATSEMDKDVKYYESIQVTMKYNLARLNEAMSSYDVADKLYKEIL 524

Human   525 REHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFE 589
            :|||||:|||||||.||||||..:.|||:||:||.||.|:|||.||:|||||||.::..|||.||
  Fly   525 KEHPNYIDCYLRLGCMARDKGLIFVASDFFKDALNINNDNPDARSLLGNLHLAKMQFALGQKNFE 589

Human   590 RILKQPSTQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIG 654
            .|||.|||.:|.||::||||..|||||||:||:|||::||::||||:|||||||.:|::|.||||
  Fly   590 TILKNPSTSTDAYSLIALGNFSLQTLHQPSRDKEKERKHQEKALAIFKQVLRNDPRNIWATNGIG 654

Human   655 AVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEV 719
            |||||||...||||:||||||||||..|||||:||:||||||||||:||||||::|||||.|.||
  Fly   655 AVLAHKGCVIEARDIFAQVREATADFCDVWLNIAHVYVEQKQYISAIQMYENCMKKFYKHNNVEV 719

Human   720 VLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVK 784
            :.|||||..:..||.:.|..|||||.|||.||||:||:|:||.|||.::||||||.|:.||.||.
  Fly   720 MQYLARAYLRANKLVDAKAVLLKARRVAPQDTVLLFNIAVVLSRLAMAILKDEKSTLEIVLQAVH 784

Human   785 ELELAHRYFSYLSKVGDKMRFDLALAATEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEK 849
            |||||.:||.|||..|||.||::.:|..||..|.||||||||||.|||:.|||||.||.|||:|:
  Fly   785 ELELAQKYFQYLSVHGDKNRFNIEVAGIEASTCQDLLSQAQYHVGRARRIDEEERSLRRKQEEER 849

Human   850 ELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKG 914
            |..:.|:.::::.:....|..:.:||.:|.:|||||||:|:. .:....||:|:|||.||:
  Fly   850 EAFKIKVAEQRKRREEEAKTSRDQLLAKRQEYVEKTKNMLII-ADAPPEKERKKGGGRGRK---- 909

Human   915 GEFDEFVN-DDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRRHPKGEEGSDDDETENG 978
               |:::: .::|:|   ..:::..:.|..:.:||.::||.||:|..:.....||..........
  Fly   910 ---DDYISGTESDND---GARREGERPSKKKGKGERKKGGGRKRKTEKYESDSEEEPGASGKSGK 968

Human   979 PKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRN------- 1036
            .|.||.:|.|..|:|....:||      |:.||..||:|:..||..:.|.......||
  Fly   969 KKGKKPKPVKESKEKLSAKQRL------KVLSKETISTSESESDGKRSKSRSRSRSRNRSGSRSG 1027

Human  1037 SNSNSDSDEDEQRKKCAS-----SESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQPSRKRRP 1096
            |.|.|.||.:..||:..|     |.|||||         .:.|:..|.|.:...:||:...:.|.
  Fly  1028 SASRSGSDREASRKRSRSRSGSGSGSDSDE---------ATKRKRARNRIESGGESDRSGSRARS 1083

Human  1097 SGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHESERGSDNEGSGQGSGNESEPEGSNNEAS 1161
            ..|.:|.:.|....||.|. |::.||..|.|........|......|...||:.|:.|..:...|
  Fly  1084 KSSSRSRSRSKSGSRSRSR-SKSGSRSRSRSKSGSRSRSRSPSGSRSRSRSGSRSKSESRSRSGS 1147

Human 1162 1161
Fly 1148 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTR9	NP_055448.1	TPR 1	41..75		19/34 (56%)
		TPR 2	129..162		29/32 (91%)
		TPR repeat	131..157	CDD:276809	23/25 (92%)
		TPR 3	163..196		27/32 (84%)
		TPR_11	165..228	CDD:290150	45/62 (73%)
		TPR repeat	165..191	CDD:276809	20/25 (80%)
		TPR repeat	196..227	CDD:276809	20/30 (67%)
		TPR_11	198..266	CDD:290150	43/67 (64%)
		TPR 4	198..231		19/32 (59%)
		TPR 5	235..268		21/32 (66%)
		TPR repeat	269..297	CDD:276809	25/27 (93%)
		TPR 6	306..339		27/32 (84%)
		TPR repeat	306..334	CDD:276809	24/27 (89%)
		tol_pal_ybgF	310..420	CDD:188247	86/109 (79%)
		TPR repeat	340..370	CDD:276809	25/29 (86%)
		TPR 7	341..374		26/32 (81%)
		TPR repeat	375..406	CDD:276809	24/30 (80%)
		TPR 8	412..444		23/31 (74%)
		TPR repeat	412..437	CDD:276809	19/24 (79%)
		TPR repeat	444..487	CDD:276809	19/42 (45%)
		TPR 9	451..484		16/32 (50%)
		TPR_12	453..521	CDD:290160	34/67 (51%)
		TPR 10	497..530		21/32 (66%)
		TPR_12	498..563	CDD:290160	44/64 (69%)
		TPR repeat	501..525	CDD:276809	15/23 (65%)
		TPR repeat	530..560	CDD:276809	21/29 (72%)
		TPR 11	531..564		22/32 (69%)
		TPR repeat	565..593	CDD:276809	18/27 (67%)
		TPR 12	566..598		21/31 (68%)
		TPR 13	613..646		24/32 (75%)
		TPR_11	646..709	CDD:290150	50/62 (81%)
		TPR 14	647..680		25/32 (78%)
		TPR repeat	648..675	CDD:276809	20/26 (77%)
		TPR repeat	680..712	CDD:276809	24/31 (77%)
		TPR 15	681..714		26/32 (81%)
		TPR 16	717..750		18/32 (56%)
		TPR repeat	717..743	CDD:276809	12/25 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..1173		79/283 (28%)
		PHA03249	1034..>1173	CDD:223023	40/140 (29%)
		SEEEED	1041..1154	CDD:291463	34/117 (29%)
Ctr9	NP_788448.1	TPR repeat	130..157	CDD:276809	24/26 (92%)
		TPR_11	166..228	CDD:290150	45/61 (74%)
		TPR repeat	166..191	CDD:276809	20/24 (83%)
		TPR repeat	196..227	CDD:276809	20/30 (67%)
		TPR repeat	269..300	CDD:276809	28/30 (93%)
		TPR_11	305..372	CDD:290150	53/66 (80%)
		TPR repeat	306..334	CDD:276809	24/27 (89%)
		TPR repeat	340..370	CDD:276809	25/29 (86%)
		TPR_1	344..374	CDD:278916	23/29 (79%)
		TPR repeat	375..406	CDD:276809	24/30 (80%)
		NRDE-2	400..>532	CDD:285605	79/131 (60%)
		TPR repeat	412..437	CDD:276809	19/24 (79%)
		TPR repeat	501..525	CDD:276809	15/23 (65%)
		TPR repeat	530..560	CDD:276809	21/29 (72%)
		TPR repeat	565..593	CDD:276809	18/27 (67%)
		TPR repeat	646..676	CDD:276809	22/29 (76%)
		TPR repeat	681..709	CDD:276809	23/27 (85%)
		TPR_11	682..748	CDD:290150	45/65 (69%)
		TPR repeat	716..746	CDD:276809	16/29 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158749
Domainoid	1	1.000	241	1.000	Domainoid score	I2252
eggNOG	1	0.900	-	-		E2759_KOG2002
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40668
Inparanoid	1	1.050	1305	1.000	Inparanoid score	I157
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54530
OrthoDB	1	1.010	-	-		D396755at2759
OrthoFinder	1	1.000	-	-		FOG0003745
OrthoInspector	1	1.000	-	-		oto90158
orthoMCL	1	0.900	-	-		OOG6_102191
Panther	1	1.100	-	-	LDO	PTHR14027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.810