DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTR9 and CG9899

DIOPT Version :9

Sequence 1:	NP_055448.1	Gene:	CTR9 / 9646	HGNCID:	16850	Length:	1173	Species:	Homo sapiens
Sequence 2:	NP_611764.1	Gene:	CG9899 / 37676	FlyBaseID:	FBgn0034829	Length:	922	Species:	Drosophila melanogaster

Alignment Length:	983	Identity:	276/983 - (28%)
Similarity:	474/983 - (48%)	Gaps:	112/983 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    41 LHIWIALALEYYKQGKTEEFVKLLEAARIDGNLDYRDHEKDQMTCLDTLAAYYVQQARKEKNKDN 105
            |..:|..|:|:|..||..:|..::|.........|..::::.......||.|....|.|
  Fly     5 LSTYIEEAMEFYAIGKGADFKAIIEKGIASCMTTYSTYDRELYKAYALLATYLSNHAFK------ 63

Human   106 KKDLITQATLLYTMA----DKIIMYDQNH----LLGRACFCLLEGDKMDQADAQFHFVLNQSPNN 162
               :|........||    |::....|.|    .:.:....:|...:...|||....||...|.|
  Fly    64 ---IIKSRPAFQAMAINCFDQLDSLRQQHDPHLQVTKGFLWMLSSSRAQDADALLISVLRNHPKN 125

Human   163 IPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALEL 227
            |.||:|:||:::|::||.|||.|:|..|...|...|:|.:|:||||.|:.:||||:|:|..|||.
  Fly   126 ILALIGRACLAYNRQDYIGALGYFKSVLLIQPQGMADVWVGIGHCFWKMGELEKAQLSFQIALEH 190

Human   228 NSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLA 292
            |.:|:.|.:.||:::..:.:..|.::|..||:.||..:..||.:|:.||..::...::..|...|
  Fly   191 NGQCLNAALALALVKFEHNDEQSYQDGKMLLTAAYKENNKNPDLLSILAGMYYADGNHKLVWSFA 255

Human   293 LHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDK 357
            .:|...|..:.:::.:.:|:|:|:|....::.|.:||..:.:.|...::||..|:.|||::.|:.
  Fly   256 GNAIKFTANKHIESRNYFQIAKSYHATGQFESAKKYYLLSAKSAPDGYILPLVGVAQMYLHEGEL 320

Human   358 ENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTE--QYPDDVEAWIELAQ 420
            ..:....|..|.:.|:....|.:|..:|...:..||.|.|...|.||.|  .|..:..:|:.||.
  Fly   321 NRSKAFLESFLTSEPDEPVVMDLLAKIYLEYKCPEKIDKAIEMLVKVVESASYHQNTNSWLNLAF 385

Human   421 ILEQTDIQG-ALSAYGTATRI-LQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKA 483
            ..||..:.. .::||..|..| |.:..|  :|.|.|||:.:...    :.:..:..|.:||.|.:
  Fly   386 AYEQKRLWAHGVNAYQKAIDIYLSQGHQ--IPIEWLNNLASSQL----MAKMPEKALNTLDDALS 444

Human   484 EA---EHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKG 545
            :.   ..|....|.:|:  .||...:.|.:..|..|.:.||:|.:|:.:|.|||||||.||..|.
  Fly   445 KCRVMNSDNKTTNLLSL--QYNRGLVLEELHMFTLAAENYKSITKEYSSYHDCYLRLGVMAIQKN 507

Human   546 NFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEW------GPGQKKF-----ERILKQPSTQS 599
            |..:|.:..|:.|           :..||::..:.:      |....||     ..||.:.|..:
  Fly   508 NHTQAIEHLKDIL-----------VEDNLNMTARTYMGDCFKGLSLDKFATFNYNMILARQSKFT 561

Human   600 DTYSMLALGNVWLQTLHQ--PTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGY 662
            :||..:|:||..|:.|..  ...:....::.|::||..:.::|..:.|||:|||||||||:....
  Fly   562 NTYVSMAMGNFCLEKLQNWIAEGNFRAARKQQEKALQCFGKILDCNPKNLWAANGIGAVLSSCNN 626

Human   663 FREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARAL 727
            ......:|.|:.|.........:|.|||.:...||..|:|.||.||:........:|:..||:||
  Fly   627 LSAGGAIFKQIIECGNKCIPAIINSAHIALVSGQYRLAIQTYERCLKDHLPKNRVDVMHCLAKAL 691

Human   728 FKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRY 792
            :..|..::.|..|||.||:.|.|..::||:.|.:::.....|...:..|.|::.....|::|.:.
  Fly   692 YDNGDARKAKMWLLKVRHLVPHDPFVIFNLGLAIKKETEQALALPRPQLDELMGLDGLLKVAFKL 756

Human   793 FSYLSKVGDKMRFDLALAATEARQCSDLLSQAQYHVARARKQDE----EERELRAKQEQEKELL- 852
            |.:::.  :..:..:.::|..|..|.:|:::.   :|:.|:..|    ||..::.::::.::.:
  Fly   757 FCHINL--NHPKISVRVSAKYAEDCQNLMTEL---IAKKRQASESHAMEEDRVQLQKQRYRDHIE 816

Human   853 --RQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNIL----------MFTGETEATKEKKRGG 905
              ||:.|:.:||:|:|    ::.|..||.:.:|:|:.|:          ...|...|.|.::.|.
  Fly   817 HQRQQELQREEEERVR----RENLKIQRKEVLERTRKIISAPLAPDVPKKSAGNGRAKKNQENGD 877

Human   906 GGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRRHPKGEE-- 968
            |   ::||.|.               .|||.|::.:|.|||..     |..||     ||.:|
  Fly   878 G---KAKKSGP---------------PKKKTRKRAAGKEQEDI-----EPLKK-----PKSKEFI 914

Human   969 GSDDDETE 976
            .:|||.:|
  Fly   915 DTDDDNSE 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTR9	NP_055448.1	TPR 1	41..75		9/33 (27%)
		TPR 2	129..162		8/36 (22%)
		TPR repeat	131..157	CDD:276809	5/25 (20%)
		TPR 3	163..196		16/32 (50%)
		TPR_11	165..228	CDD:290150	32/62 (52%)
		TPR repeat	165..191	CDD:276809	13/25 (52%)
		TPR repeat	196..227	CDD:276809	16/30 (53%)
		TPR_11	198..266	CDD:290150	28/67 (42%)
		TPR 4	198..231		18/32 (56%)
		TPR 5	235..268		8/32 (25%)
		TPR repeat	269..297	CDD:276809	7/27 (26%)
		TPR 6	306..339		8/32 (25%)
		TPR repeat	306..334	CDD:276809	7/27 (26%)
		tol_pal_ybgF	310..420	CDD:188247	32/111 (29%)
		TPR repeat	340..370	CDD:276809	9/29 (31%)
		TPR 7	341..374		10/32 (31%)
		TPR repeat	375..406	CDD:276809	10/30 (33%)
		TPR 8	412..444		10/33 (30%)
		TPR repeat	412..437	CDD:276809	7/25 (28%)
		TPR repeat	444..487	CDD:276809	10/45 (22%)
		TPR 9	451..484		8/32 (25%)
		TPR_12	453..521	CDD:290160	15/70 (21%)
		TPR 10	497..530		9/32 (28%)
		TPR_12	498..563	CDD:290160	24/64 (38%)
		TPR repeat	501..525	CDD:276809	8/23 (35%)
		TPR repeat	530..560	CDD:276809	15/29 (52%)
		TPR 11	531..564		14/32 (44%)
		TPR repeat	565..593	CDD:276809	6/38 (16%)
		TPR 12	566..598		8/42 (19%)
		TPR 13	613..646		5/34 (15%)
		TPR_11	646..709	CDD:290150	25/62 (40%)
		TPR 14	647..680		13/32 (41%)
		TPR repeat	648..675	CDD:276809	11/26 (42%)
		TPR repeat	680..712	CDD:276809	12/31 (39%)
		TPR 15	681..714		12/32 (38%)
		TPR 16	717..750		13/32 (41%)
		TPR repeat	717..743	CDD:276809	9/25 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..1173		26/87 (30%)
		PHA03249	1034..>1173	CDD:223023
		SEEEED	1041..1154	CDD:291463
CG9899	NP_611764.1	TPR_11	125..191	CDD:290150	34/65 (52%)
		TPR repeat	125..155	CDD:276809	16/29 (55%)
		TPR repeat	161..189	CDD:276809	15/27 (56%)
		TPR	174..443	CDD:223533	78/274 (28%)
		TPR repeat	272..297	CDD:276809	7/24 (29%)
		PEP_TPR_lipo	275..>735	CDD:274350	140/478 (29%)
		TPR repeat	303..333	CDD:276809	9/29 (31%)
		TPR repeat	338..369	CDD:276809	10/30 (33%)
		TPR repeat	376..406	CDD:276809	8/29 (28%)
		TPR repeat	416..444	CDD:276809	8/31 (26%)
		TPR repeat	458..488	CDD:276809	9/31 (29%)
		TPR repeat	493..520	CDD:276809	13/26 (50%)
		TPR repeat	580..605	CDD:276809	3/24 (13%)
		TPR repeat	610..640	CDD:276809	13/29 (45%)
		TPR repeat	645..673	CDD:276809	11/27 (41%)
		TPR repeat	680..710	CDD:276809	11/29 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2002
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54530
OrthoDB	1	1.010	-	-		D396755at2759
OrthoFinder	1	1.000	-	-		FOG0003745
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.890