DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MICAL2 and Rassf

DIOPT Version :9

Sequence 1:	NP_001380866.1	Gene:	MICAL2 / 9645	HGNCID:	24693	Length:	1957	Species:	Homo sapiens
Sequence 2:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster

Alignment Length:	907	Identity:	171/907 - (18%)
Similarity:	278/907 - (30%)	Gaps:	318/907 - (35%)

- Green bases have known domain annotations that are detailed below.

Human  1002 CYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKF--YCK---------PH 1055
            |:.|.|.||..||..:.|:.:|.||.||..|...|....:.    |.|.  ||.         |.
  Fly     4 CHKCGKPVYFAERKQSIGYDWHPECLRCEECGKRLNPGQHA----EHKSVPYCHVPCYGALFGPQ 64

Human  1056 FIHCKTNSKQRKR------------------------RAELK-----------QQREEEAT---- 1081
            .....|..:..|.                        .::||           :.|..|..
  Fly    65 LFGHGTRVESHKSYGVKGAQKPTGAQANGPPLPRDHLESKLKVYNQFYDNKSLEIRSREVNNRLV 129

Human  1082 --------W--------QEQEAPRRDTPTESSCAVAAIGTLEGSPPDEPTSPKRPKSISEPQHSD 1130
                    |        :|.:..|......:||.|:.......|..:...|    :|::.|..:.
  Fly   130 LEGALRVYWGVQGVIHLKEDDDQRILVRKRNSCRVSKAANESSSDKENEAS----ESLAPPTTTT 190

Human  1131 AEGDAASPLPSEWTSVRISPGEEAAGQDVLAVRVL----VTSEDSSSDTESDYGGSEGSHTEPCE 1191
            ||.|..|      |.|.:|   |:...|..::..:    .|.||:|::|.::  ..|.::...|.
  Fly   191 AEVDQLS------TDVSLS---ESMTFDSCSLNEISELPTTPEDASANTTAN--SKEQTNGNVCN 244

Human  1192 EKPWRPGSPHLPHTSLGEALSRAVSPQCPEEPRAVHAALQRANSFQSPTPSKYQNWRREFW---W 1253
            :.         ..|:..::....|     |.|.|      ..:...|..|||.....:..|   .
  Fly   245 DD---------EDTTTTDSSGTLV-----EAPTA------STSCVSSTLPSKLDRLEKLDWDDID 289

Human  1254 SLTPVNKR---------TMSPPKDPSPSLPLPSSSSHSSSPPSSSSTSV----------SGNAPD 1299
            .|..|.:|         || |.|       ||||.|.|.|.||.:||..          |.:...
  Fly   290 DLLQVERRHNDKDRIYETM-PVK-------LPSSQSSSDSSPSKTSTETTTTTESSSTQSASTNT 346

Human  1300 GSSPPQMTASEPL---------SQVSRGHPSPPTPNFR---------------RRAVAQGAPREI 1340
            .|:...|||:..|         :.||....|  ..||.               :|:|.|
  Fly   347 SSTDDFMTATGSLTANTNTQNTTTVSTTETS--LDNFETCDDATLKPIDFEDFKRSVHQ------ 403

Human  1341 PLYLPHHPKPEWAEYCLVSPGEDGLSDPAEMTSDECQPAEAPLGDIGSNHRDPHPIWGKDRSWTG 1405
                         :|.   .|.:..::|.|.|....||.:.      |...|...::|::.:.:.
  Fly   404 -------------DYV---NGANSFTEPNEGTLKRNQPIDP------SRIHDSLKLYGENSAMSK 446

Human  1406 --------QELSPLAGEDREKGSTGARKEEEGGPVLVKEKLGLKK----LVLTQEQKTMLLDWND 1458
                    :.:.|....|     |...:...|.|...:.:..|:|    .|.:::||.
  Fly   447 SFNCEHALRSIDPTLIND-----TMNLRSSVGSPHSAQRQYALQKSGSATVTSRDQKK------- 499

Human  1459 SIPESVHLKAGERISQKSAENGRGG--------------RVLKPVRPLLLPRAAGEPLPTQRGAQ 1509
                  ..:.|.::.:|.....:.|              ..|:|.|...:.|:   .:| ||..|
  Fly   500 ------PYQQGRQLFEKGINRSKSGPSCFVYSDSDDDDEATLRPQRMATIRRS---DIP-QRYIQ 554

Human  1510 EKMGT-PAEQ----AQGERN-VPPPKSPLRLIANAIRRSLEPLLSNSE--------GGKKAWAKQ 1560
            .:|.. |.|.    ::||.: ...|.......|.......|.|.:.||        |.......:
  Fly   555 IQMDCYPKENVAAASEGESSRADAPSITSGAAAGDELTQTEDLYTASEGVDGPDGDGSAGLHVTE 619

Human  1561 ESKTLPAQACTRSFSLRKTNSNK------------DGDQHSPGRNQSSAFSPPDPALRTHSLPNR 1613
            :...|.....|.:.::::.:.|:            :|..::   .::|.|:||
  Fly   620 DGVVLRRPPRTGASAIKRRSGNRRSRTKLKRRCSINGHYYN---RETSFFTPP------------ 669

Human  1614 PSKVFPALRSPPCSKIEDVPTLLEKVSL-QENFPDASKPPKKRISLF------SSLRLKDKSF-- 1669
                   ..|.....:..:.|..|.::| .|.:...|.|  ...|||      ...||||..:
  Fly   670 -------YGSQMSVWVSSMVTTTEVINLVLEKYKVDSSP--GNFSLFIVRDNGEQKRLKDDEYPL 725

Human  1670 -------------ESFLQESRQRKDIRDLFGSPKRKVLPEDSAQALEKLLQPFKSTSLRQAA 1718
                         ..||.:||:..:|.:.........|||..|     :|:.:.....|:.|
  Fly   726 ITRVTLGPHEDVARIFLVDSRKTDEISNEVAQFLNLSLPECRA-----ILERYDQELAREVA 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICAL2	NP_001380866.1	Monooxygenase domain. /evidence=ECO:0000250\|UniProtKB:Q8VDP3	2..494
		UbiH	87..>226	CDD:357568
		CH	522..617	CDD:214479
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..714
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:24440334	660..681
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..942
		LIM_Mical	1002..1056	CDD:188823	20/64 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1072..1094		7/52 (13%)
		PHA03247	<1087..1624	CDD:223021	117/638 (18%)
		ProQ	1628..1718	CDD:198013	24/111 (22%)
		DUF5401	<1773..>1944	CDD:375164
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785	19/56 (34%)
		UBQ	660..744	CDD:294102	20/107 (19%)
		Nore1-SARAH	762..799	CDD:293125	7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810