Protein Alignment IKBKE and ATG1

DIOPT Version :10

• Sequence 1: NP_054721.1
• Gene: IKBKE / 9641
• HGNCID: 14552
• Length: 716
• Species: Homo sapiens
• Sequence 2: NP_011335.1
• Gene: ATG1 / 852695
• SGDID: S000003148
• Length: 897
• Species: Saccharomyces cerevisiae
• Alignment Length: 878
• Identity: 177/878 - (20%)
• Similarity: 301/878 - (34%)
• Gaps: 262/878 - (29%)

Human     1 MQSTANYLWHTDDLLGQGATASVYKAR-NKKSGELVAVKVFNTTSYLRPREVQVREFE--VLRKL 62
            |.|..||.  .:..:|:|:.|:||:.. .....:.||:|..:.......:.::..|.|  :|:|:
Yeast    18 MASAGNYT--AEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKI 80

Human    63 NHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLE---------------------SPENAFG 106
            .|.:||.|...|.|  |....|:||||:.|.|..:|:                     ..||..|
Yeast    81 KHPHIVGLIDCERT--STDFYLIMEYCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSENHNG 143

Human   107 LPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNI-----------------MRLVGEEGQSIYK 154
            |.....|..|:.:.:.:..||...:|||||||.|:                 :..||.....|.|
Yeast   144 LHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILK 208

Human   155 LTDFGAARELDDDEKFVSVYGTEEYLHPDM--YERAVLRKPQQKAFGVTVDLWSIGVTLYHAATG 217
            :.|||.||.|.:.....::.|:..|:.|::  |::          :....||||:|..::....|
Yeast   209 IADFGFARFLPNTSLAETLCGSPLYMAPEILNYQK----------YNAKADLWSVGTVVFEMCCG 263

Human   218 SLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILA 282
            :.||    ....:.|:..:|             :|.|..:    |.|..|    .::.:|..::.
Yeast   264 TPPF----RASNHLELFKKI-------------KRANDVI----TFPSYC----NIEPELKELIC 303

Human   283 NILEVEQAKCWGFDQFFA-----------ETSDIL------------------------------ 306
            ::|..:.|:..||::|||           |..|.|
Yeast   304 SLLTFDPAQRIGFEEFFANKVVNEDLSSYELEDDLPELESKSKGIVESNMFVSEYLSKQPKSPNS 368

Human   307 -----QRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYL----FEGHLCVLE 362
                 |.:..:...||.|:.:...:.|........:||.|:.|....|...:    ||....|:|
Yeast   369 NLAGHQSMADNPAELSDALKNSNILTAPAVKTDHTQAVDKKASNNKYHNSLVSDRSFEREYVVVE 433

Human   363 -PSVSAQHIA--------------HTTAS------------------------SPLTLFSTAIPK 388
             .||....:|              |.|::                        :|..|.:|:...
Yeast   434 KKSVEVNSLADEVAQAGFNPNPIKHPTSTQNQNVLLNEQFSPNNQQYFQNQGENPRLLRATSSSS 498

Human   389 G-------LAFRDPALDVPKFVPKVDLQADYNTAKGVL--GAGYQALR--------LARALLDGQ 436
            |       .:..|..|.:....|...|......|...|  ||..|..:        .::.||:.|
Yeast   499 GGSDGSRRPSLVDRRLSISSLNPSNALSRALGIASTRLFGGANQQQQQQQITSSPPYSQTLLNSQ 563

Human   437 ELMFRGL--HWVMEVLQATCRRTLEVARTSLLYLSSSLGTE----------RFSSVAGTPEIQEL 489
              :|..|  :.::.:.......||::..|:::.:..||..:          :||.:  .|....|
Yeast   564 --LFHELTENIILRIDHLQHPETLKLDNTNIVSILESLAAKAFVVYSYAEVKFSQI--VPLSTTL 624

Human   490 KAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSIQQI-QCCLDKMNFI 553
            |..|...:|       .|..|..|.|.|:           |.|...||.::::. :.||....|
Yeast   625 KGMANFENR-------RSMDSNAIAEEQD-----------SDDAEEEDETLKKYKEDCLSTKTF- 670

Human   554 YKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETR 618
                       |.|.......:| ...|:.|.:..:.:...|.:..|..:|....|.|:|.....
Yeast   671 -----------GKGRTLSATSQL-SATFNKLPRSEMILLCNEAIVLYMKALSILSKSMQVTSNWW 723

Human   619 NHLRLVGCSVAACNTEAQGVQESLSKLLEE-------------------LSHQLLQDRAKGAQAS 664
            ...:...||:.. |...|.::|..::.||:                   ..:|.|::  ||:...
Yeast   724 YESQEKSCSLRV-NVLVQWLREKFNECLEKADFLRLKINDLRFKHASEVAENQTLEE--KGSSEE 785

Human   665 PPPIAPYPSPTRKDLLLHMQELCEGMKLLASDL 697
            |    .|......|..|.:.::...|:|...:|
Yeast   786 P----VYLEKLLYDRALEISKMAAHMELKGENL 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKBKE	NP_054721.1	Protein Kinases, catalytic domain	15..330	CDD:473864	88/403 (22%)
		Ubl_IKKE	308..385	CDD:340648	20/119 (17%)
		Interaction with DDX3X	383..647		56/293 (19%)
		TBK1_CCD1	400..646	CDD:465742	52/268 (19%)
		Leucine-zipper	436..457		3/22 (14%)
		TBK1_IKKE-like_C	675..715	CDD:425366	5/23 (22%)
ATG1	NP_011335.1	STKc_ATG1_ULK_like	30..324	CDD:270911	80/330 (24%)
		DUF3543	586..893	CDD:463451	51/269 (19%)