DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKBKE and STE11

DIOPT Version :9

Sequence 1:	NP_054721.1	Gene:	IKBKE / 9641	HGNCID:	14552	Length:	716	Species:	Homo sapiens
Sequence 2:	NP_013466.1	Gene:	STE11 / 851076	SGDID:	S000004354	Length:	717	Species:	Saccharomyces cerevisiae

Alignment Length:	304	Identity:	77/304 - (25%)
Similarity:	129/304 - (42%)	Gaps:	70/304 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     9 WHTDDLLGQGATASVYKARNKKSGELVAV---------------------------------KVF 40
            |.....:|.|:..|||...|..:|||:||                                 |:.
Yeast   415 WLKGACIGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIE 479

Human    41 NTTSYLRPREVQ----------VREFEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLL 95
            :..:...|:..|          ..|..:|::|:|:|||..:...:.||:..  :.:||...||:.
Yeast   480 DVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLN--IFLEYVPGGSVS 542

Human    96 SVLESPENAFGLPEDEFLVV--LRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDF 158
            |:|    |.:| |.:|.|:.  .|.::.|:.:|.:..|:|||||..||  |:..:|  ..|:|||
Yeast   543 SML----NNYG-PFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANI--LIDIKG--CVKITDF 598

Human   159 GAARELD----DDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSL 219
            |.:::|.    ...|..|:.|:..::.|::.        :|.|.....|:||.|..:....||..
Yeast   599 GISKKLSPLNKKQNKRASLQGSVFWMSPEVV--------KQTATTAKADIWSTGCVVIEMFTGKH 655

Human   220 PFIPFGGPRRNKEIMYRITTEKPAGAIAGAQR--RENGPLEWSY 261
            ||..|...:...:|....|.|.|:.|.:..:.  |:...|::.|
Yeast   656 PFPDFSQMQAIFKIGTNTTPEIPSWATSEGKNFLRKAFELDYQY 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKBKE	NP_054721.1	PKc_like	15..330	CDD:328722	76/298 (26%)
		UBL_TBK1_like	297..383	CDD:240618
		Interaction with DDX3X	383..647
		Leucine-zipper	436..457
STE11	NP_013466.1	SAM_Ste11_fungal	20..82	CDD:188933
		Ras_bdg_2	121..224	CDD:405528
		PKc_like	415..712	CDD:419665	77/304 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910