Protein Alignment IKBKE and Ikbke

DIOPT Version :10

• Sequence 1: NP_054721.1
• Gene: IKBKE / 9641
• HGNCID: 14552
• Length: 716
• Species: Homo sapiens
• Sequence 2: NP_062751.2
• Gene: Ikbke / 56489
• MGIID: 1929612
• Length: 717
• Species: Mus musculus
• Alignment Length: 721
• Identity: 598/721 - (82%)
• Similarity: 655/721 - (90%)
• Gaps: 9/721 - (1%)

Human     1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQ 65
            ||||.||||||||||||||||||||||||||||:|||||||:.||.||.|||||||||||:||||
Mouse     1 MQSTTNYLWHTDDLLGQGATASVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRLNHQ 65

Human    66 NIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENG 130
            |||||||||||||||||||:||||||||||||||.|||.|||.|:||||||||||||||||||||
Mouse    66 NIVKLFAVEETGGSRQKVLIMEYCSSGSLLSVLEDPENTFGLSEEEFLVVLRCVVAGMNHLRENG 130

Human   131 IVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQ 195
            |||||||||||||||||||||||||:||||||:||||||||||||||||||||||||||||||||
Mouse   131 IVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQ 195

Human   196 KAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWS 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|.|::||||||||
Mouse   196 KAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAISGTQKQENGPLEWS 260

Human   261 YTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIY 325
            |:|||||:||:|||:|||||||||||||:.||||||||||||||||||.|:|||||.||||||:|
Mouse   261 YSLPITCRLSMGLQNQLVPILANILEVEEDKCWGFDQFFAETSDILQRTVIHVFSLPQAVLHHVY 325

Human   326 IHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTA--IPK 388
            ||||||||||.|||::||:|.|:|||||||||.||||||:||||||||.|||||||||.:  .||
Mouse   326 IHAHNTIAIFLEAVYEQTNVTPKHQEYLFEGHPCVLEPSLSAQHIAHTAASSPLTLFSMSSDTPK 390

Human   389 GLAFRDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQAT 453
            ||||||||||||||||||||||||:|||||||||||||.|||.|||||.||.||||||:||||.|
Mouse   391 GLAFRDPALDVPKFVPKVDLQADYSTAKGVLGAGYQALWLARVLLDGQALMLRGLHWVLEVLQDT 455

Human   454 CRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQE 518
            |::||||.||:|||||||||||||||.||.|::||.|.|.|||:||:||:|:||:||.|:||||.
Mouse   456 CQQTLEVTRTALLYLSSSLGTERFSSGAGMPDVQERKEATELRTRLQTLSEILSKCSHNVTETQR 520

Human   519 SLSSLNRELVKSRDQVHED-RSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFS 582
            |||.|..||:|:|||:||| :|||:||||||||:|||||||||||||||.|||||||||||||||
Mouse   521 SLSCLGEELLKNRDQIHEDNKSIQKIQCCLDKMHFIYKQFKKSRMRPGLSYNEEQIHKLDKVNFS 585

Human   583 HLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLE 647
            ||||||||||||||||.||.||||||||||.|...:|||.|:|.|||.||:||:|.||||:|:.:
Mouse   586 HLAKRLLQVFQEECVQTYQVSLVTHGKRMRQVQRAQNHLHLIGHSVATCNSEARGAQESLNKIFD 650

Human   648 ELSHQLLQDRA--KGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRV 710
                |||.|||  :||:.||.|:||:|.|..|||:.||||||..|||||.||.||||:||||:||
Mouse   651 ----QLLLDRASEQGAEVSPQPMAPHPGPDPKDLVFHMQELCNDMKLLAFDLQDNNRLIERLHRV 711

Human   711 PAPPDV 716
            |:.|||
Mouse   712 PSAPDV 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKBKE	NP_054721.1	Protein Kinases, catalytic domain	15..330	CDD:473864	287/314 (91%)
		Ubl_IKKE	308..385	CDD:340648	63/76 (83%)
		Interaction with DDX3X	383..647		208/266 (78%)
		TBK1_CCD1	400..646	CDD:465742	194/246 (79%)
		Leucine-zipper	436..457		15/20 (75%)
		TBK1_IKKE-like_C	675..715	CDD:425366	27/39 (69%)
Ikbke	NP_062751.2	Protein Kinases, catalytic domain	15..330	CDD:473864	287/314 (91%)
		Ubl_IKKE	308..383	CDD:340648	61/74 (82%)
		Interaction with DDX3X. /evidence=ECO:0000250	385..650		207/264 (78%)
		TBK1_CCD1	402..648	CDD:465742	193/245 (79%)
		Leucine-zipper	452..473		15/20 (75%)
		TBK1_IKKE-like_C	670..716	CDD:425366	31/45 (69%)