Protein Alignment IKBKE and IKKbeta

DIOPT Version :10

• Sequence 1: NP_054721.1
• Gene: IKBKE / 9641
• HGNCID: 14552
• Length: 716
• Species: Homo sapiens
• Sequence 2: NP_524751.3
• Gene: IKKbeta / 44432
• FlyBaseID: FBgn0024222
• Length: 717
• Species: Drosophila melanogaster
• Alignment Length: 812
• Identity: 191/812 - (23%)
• Similarity: 305/812 - (37%)
• Gaps: 207/812 - (25%)

Human     1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYL-RPREVQV----------- 53
            |.|..|  |.....||:|....|...||:.:|..:|.|.......| ..::|::
  Fly     1 MHSFGN--WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWS 63

Human    54 REFEVLRKLNHQNIVKLFAVEETG---------GSRQKVLVMEYCSSGSLLSVLESPENAFGLPE 109
            |:|:     |..:||....:|:..         .::..|:|:|||:.|.:...|:|||||.||.|
  Fly    64 RQFK-----NFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTE 123

Human   110 DEFLVVLRCVVAGMNHLREN-GIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSV 173
            .|...:|..:...::.|... ||.|||:||.||:...|.:|:.||||||||.||...|.....||
  Fly   124 FEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSV 188

Human   174 YGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRIT 238
            .||..|..|::.|...        :..||||||.||..|...||.|||||.   :..|.|:..:
  Fly   189 VGTRHYYAPEVVENGF--------YNSTVDLWSFGVIAYELVTGELPFIPH---QTLKNIILNL- 241

Human   239 TEKPAGAIAGAQRRE-NGPLEWSYTLPITCQLSLGLQSQLV-----PILANILEVEQAKCWGFDQ 297
            .:|||..||..:..| |......:.||.|..||....:|..     |:.:|..|..|........
  Fly   242 IKKPAKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPV 306

Human   298 FFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCVLE 362
            .||:...||...|:.:|:::........:.|..|:......:...|.        :.|..|..:.
  Fly   307 VFADLDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTG--------MDEKELYFVL 363

Human   363 PSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPK-----------FVPKVDLQADYNTAK 416
            |: |..|...|..|:||.|:..      .:.|.:.|..|           ::.:|..:.||...:
  Fly   364 PT-SHPHKTITPKSTPLQLYVE------EWSDTSKDSRKWTKRSNPPVMLYIFQVKKECDYKIPE 421

Human   417 GVLGAGYQALRLARALLDGQELMFRGL-HWVME--VLQATCRRTLEVARTSLLY-------LS-- 469
            .:|..      |:|..:..:   |:.. .|:.:  ||......|.|.||..:|.       ||
  Fly   422 PILSI------LSRKFIANK---FKTKERWLQKRVVLDMLYVLTKEQARYEMLVSGINERALSLE 477

Human   470 ---------SSLGTERFSSVAGTPEIQELKAAAELRSRLRTLA-----EVLSRCSQNITETQESL 520
                     .|:..:|........::..|...|:.:...|.|.     |.|:|....|.::.:|:
  Fly   478 DEMMENSFIDSIDKQRIIISFAYDQLTSLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSI 542

Human   521 SSL-------NRELVKSRDQVHEDRSIQQIQCCL---------------DKMNFIYKQFKKSRMR 563
            .|.       .:::||:.:|:.::...:.:..|.               .::|...::|.|||.:
  Fly   543 RSFLEACLREAKDMVKTTNQLRKEVCEKDLFDCARFYKKYLCNGAIISPSELNNDAEEFAKSRFK 607

Human   564 PGLGYNEEQIHKL----DKVNFSHLAKR-----LLQVFQEECVQKYQASLVTHGKRMRVVHETRN 619
            .   |||.:...|    |.:::.:...:     |||.|
  Fly   608 L---YNEGEARHLPKSIDHMHYLYFKTKESIPVLLQQF--------------------------- 642

Human   620 HLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQ 684
                       |:.:.:..|.:|..|:             .|.::|||        :.:|...|.
  Fly   643 -----------CDIKKEIFQINLQMLM-------------SASSTPPP--------KLELSAAMD 675

Human   685 ELCEGMKLLASDLLDNNRII------ERLNRV 710
            .|.......:||..|:.|.|      ||:|.:
  Fly   676 RLAISSGSPSSDPFDSLRTINAIEEAERINNI 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKBKE	NP_054721.1	Protein Kinases, catalytic domain	15..330	CDD:473864	106/342 (31%)
		Ubl_IKKE	308..385	CDD:340648	15/76 (20%)
		Interaction with DDX3X	383..647		54/331 (16%)
		TBK1_CCD1	400..646	CDD:465742	51/313 (16%)
		Leucine-zipper	436..457		4/23 (17%)
		TBK1_IKKE-like_C	675..715	CDD:425366	11/42 (26%)
IKKbeta	NP_524751.3	Protein Kinases, catalytic domain	13..316	CDD:473864	102/319 (32%)