Protein Alignment IKBKE and ikbke

DIOPT Version :10

• Sequence 1: NP_054721.1
• Gene: IKBKE / 9641
• HGNCID: 14552
• Length: 716
• Species: Homo sapiens
• Sequence 2: NP_001002751.1
• Gene: ikbke / 437024
• ZFINID: ZDB-GENE-040718-251
• Length: 721
• Species: Danio rerio
• Alignment Length: 729
• Identity: 354/729 - (48%)
• Similarity: 483/729 - (66%)
• Gaps: 34/729 - (4%)

Human     1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQ 65
            |.|||||||..:|:|||||||:||||||||:||||||||||..||.||.|||:||||||:.|||.
Zfish     1 MTSTANYLWSQEDILGQGATANVYKARNKKTGELVAVKVFNLVSYNRPYEVQMREFEVLQLLNHV 65

Human    66 NIVKLFAVEE-TGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLREN 129
            |||||||||| ....:||:|||||||.||||::||.||:||||||.|||:||.||..||||||||
Zfish    66 NIVKLFAVEEIISNPKQKILVMEYCSGGSLLNMLEQPEHAFGLPESEFLIVLHCVAHGMNHLREN 130

Human   130 GIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQ 194
            .:||||||||||||.|||:|:|:|||.||||||||:|||||||:||||||||||||||||||.||
Zfish   131 SVVHRDIKPGNIMRQVGEDGRSVYKLADFGAARELEDDEKFVSIYGTEEYLHPDMYERAVLRSPQ 195

Human   195 QKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEW 259
            |||:||:|||||||||:||.|||||||.||||||:||::|::||||||||.|||.|:.|:||:||
Zfish   196 QKAYGVSVDLWSIGVTIYHMATGSLPFRPFGGPRKNKQMMHKITTEKPAGTIAGVQKEEDGPIEW 260

Human   260 SYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHI 324
            ...||::||||.||::||||:|||||..:..|||.|.|||:.|:|||.|:.:::|||.||..:.|
Zfish   261 RDKLPLSCQLSEGLKTQLVPVLANILLADDEKCWKFPQFFSATNDILNRITIYIFSLQQATTYSI 325

Human   325 YIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPK- 388
            ||..|||::||.|.|..||.:.|..|:|||:||..:|:||:...:|.||::..|:.|.|..:.:
Zfish   326 YIQFHNTVSIFFEDVQAQTGIEPAAQQYLFQGHPLILDPSMKVVNIPHTSSDKPMILISRRLERI 390

Human   389 -GLAFRDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQA 452
             |..|.:|  :.|....|.|:.||:...|.::...:|.||:|.:|.:.::.:.:|.:   ..::.
Zfish   391 IGYPFEEP--ESPPMPGKFDVVADFVFTKTIVKVIHQYLRIAYSLQEYRQFILQGFN---SYIEQ 450

Human   453 TCRRTLEVA-RTS--LLYLSSSLGTERFSSVAGTPEIQELKAAAELRSRLRTL-AEVLSRCSQNI 513
            |....::|| |.|  .:.|.||:.||:...|.......|.....:.:.:...: ||:...|.:.|
Zfish   451 TSSEVIDVAHRISKVKMKLHSSISTEKTLHVFTQTFAHEFPDFIDSKKKFPLIEAELQHMCGRGI 515

Human   514 TETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDK 578
            .|.|..|..|...|.|..:.:..|:|||:::..|.::..::.|:.:.|....||||:|||||.:|
Zfish   516 REFQNILQYLRVTLSKHSETLANDKSIQKMEVLLSQIVDVHFQYFRDRQTRKLGYNDEQIHKFEK 580

Human   579 VNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLS 643
            :|.|...|:...:|:::|.|||...|.|..:..|.:::.:.||              ...:::|.
Zfish   581 LNLSSYLKKFKSLFKDDCFQKYLDVLNTTDRCSRALYDMQTHL--------------DKFRDTLL 631

Human   644 KLLEEL-SHQLLQ----DRAKGAQASPPPIAPYPSPTRKD--LLLHMQELCEGMKLLASDLLDNN 701
            :.:::| :|::||    :|........|..|......:|:  ::|.|..|...|:.:|.:|..||
Zfish   632 QRIQDLKAHEILQNKVLERVVHRAVQQPVKAEVVDGKKKEEHMILKMTRLKSEMEAVAWELQKNN 696

Human   702 RIIERLNRV-PAPP 714
            .:||.|:.| |..|
Zfish   697 NMIESLSVVTPTMP 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKBKE	NP_054721.1	Protein Kinases, catalytic domain	15..330	CDD:473864	230/315 (73%)
		Ubl_IKKE	308..385	CDD:340648	34/76 (45%)
		Interaction with DDX3X	383..647		69/269 (26%)
		TBK1_CCD1	400..646	CDD:465742	65/249 (26%)
		Leucine-zipper	436..457		2/20 (10%)
		TBK1_IKKE-like_C	675..715	CDD:425366	15/43 (35%)
ikbke	NP_001002751.1	Protein Kinases, catalytic domain	15..327	CDD:473864	228/311 (73%)
		TBK1_ULD	309..396	CDD:465744	35/86 (41%)
		TBK1_CCD1	401..623	CDD:465742	62/224 (28%)
		TBK1_IKKE-like_C	668..710	CDD:409261	14/41 (34%)