Protein Alignment IKBKE and Ikbke

DIOPT Version :10

• Sequence 1: NP_054721.1
• Gene: IKBKE / 9641
• HGNCID: 14552
• Length: 716
• Species: Homo sapiens
• Sequence 2: XP_017454364.1
• Gene: Ikbke / 363984
• RGDID: 1308352
• Length: 719
• Species: Rattus norvegicus
• Alignment Length: 685
• Identity: 571/685 - (83%)
• Similarity: 622/685 - (90%)
• Gaps: 9/685 - (1%)

Human     1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQ 65
            ||||.||||||||||||||||:|||||||||||:|||||||:.||.||.|||||||||||:|:|:
  Rat     1 MQSTTNYLWHTDDLLGQGATANVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRLDHE 65

Human    66 NIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENG 130
            ||||||||||||||||||||||||||||||||||.|||.|||||:||||||||||||||||||||
  Rat    66 NIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLEDPENTFGLPEEEFLVVLRCVVAGMNHLRENG 130

Human   131 IVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQ 195
            ||||||||||||||||:||||||||:||||||:||||||||||||||||||||||||||||||||
  Rat   131 IVHRDIKPGNIMRLVGKEGQSIYKLSDFGAARKLDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQ 195

Human   196 KAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWS 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|.|::||||||||
  Rat   196 KAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAISGTQKQENGPLEWS 260

Human   261 YTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIY 325
            |:|||||:||:|||||||||||||||.|||||||||||||||||||||.|:|||||.||||||||
  Rat   261 YSLPITCRLSVGLQSQLVPILANILEAEQAKCWGFDQFFAETSDILQRTVIHVFSLPQAVLHHIY 325

Human   326 IHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTA--IPK 388
            ||||||||||.|||::||:|||:||||.||||.||||||:||||||||.|||||||||.|  .||
  Rat   326 IHAHNTIAIFLEAVYEQTNVAPKHQEYFFEGHPCVLEPSLSAQHIAHTAASSPLTLFSMASDTPK 390

Human   389 GLAFRDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQAT 453
            ||||||||||||||||||||||||:|||||||||||||.|||.|||||.||.||||||:.|||.|
  Rat   391 GLAFRDPALDVPKFVPKVDLQADYSTAKGVLGAGYQALWLARVLLDGQALMLRGLHWVLVVLQNT 455

Human   454 CRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQE 518
            |::|||:.||:||:|||||||||.||.||..:|||||.|.||||||:|.:||||:||.|:||||.
  Rat   456 CQQTLEITRTALLFLSSSLGTERLSSGAGMLDIQELKEATELRSRLQTFSEVLSKCSHNVTETQR 520

Human   519 SLSSLNRELVKSRDQVHED-RSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFS 582
            |||.|..||:|||||:||| ||||:||||||||:|||||||||||||||.|||||||||||||||
  Rat   521 SLSCLVGELLKSRDQIHEDNRSIQKIQCCLDKMHFIYKQFKKSRMRPGLSYNEEQIHKLDKVNFS 585

Human   583 HLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLE 647
            ||||||||||||||.|.||.||||||||||.|.:.:|||.|:|.|||.||:||:|.||||:|:.:
  Rat   586 HLAKRLLQVFQEECAQTYQVSLVTHGKRMRQVQKAQNHLHLIGHSVATCNSEARGAQESLAKMFD 650

Human   648 ELSHQLLQDRA--KGAQASPPPIAPYPSPTRKDLL 680
                |||.|||  :||:.||.|:|.:|.|..|||:
  Rat   651 ----QLLLDRASKQGAEVSPQPMATHPGPDPKDLV 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKBKE	NP_054721.1	Protein Kinases, catalytic domain	15..330	CDD:473864	288/314 (92%)
		Ubl_IKKE	308..385	CDD:340648	64/76 (84%)
		Interaction with DDX3X	383..647		208/266 (78%)
		TBK1_CCD1	400..646	CDD:465742	193/246 (78%)
		Leucine-zipper	436..457		14/20 (70%)
		TBK1_IKKE-like_C	675..715	CDD:425366	3/6 (50%)
Ikbke	XP_017454364.1	Protein Kinases, catalytic domain	15..330	CDD:473864	288/314 (92%)
		Ubl_IKKE	308..383	CDD:340648	62/74 (84%)
		TBK1_CCD1	402..648	CDD:465742	192/245 (78%)