Protein Alignment IKBKE and IKKepsilon

DIOPT Version :10

• Sequence 1: NP_054721.1
• Gene: IKBKE / 9641
• HGNCID: 14552
• Length: 716
• Species: Homo sapiens
• Sequence 2: NP_610048.2
• Gene: IKKepsilon / 35329
• FlyBaseID: FBgn0086657
• Length: 720
• Species: Drosophila melanogaster
• Alignment Length: 685
• Identity: 268/685 - (39%)
• Similarity: 397/685 - (57%)
• Gaps: 65/685 - (9%)

Human     1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQ 65
            ::.:.:|:|.|..:||:|||.||::..||.:||.||||.||..|::||.:||:||||.|:|:||:
  Fly     4 LRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE 68

Human    66 NIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENG 130
            |||||.|:||....|.||:|||.|:.|||.::|:.|||::||||.|||:||..:.|||.|||:|.
  Fly    69 NIVKLLAIEEDQEGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNK 133

Human   131 IVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQ 195
            :||||:||||||:.:.|:||:|||||||||||||:|::.|.|:||||||||||:||||||||..|
  Fly   134 LVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQ 198

Human   196 KAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWS 260
            ::|...||||||||||||.|||:|||.|||| |:|:|.|::|||:|.:|.|:|.|..||||:|||
  Fly   199 RSFTANVDLWSIGVTLYHVATGNLPFRPFGG-RKNRETMHQITTKKASGVISGTQLSENGPIEWS 262

Human   261 YTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIY 325
            .|||....||.||::.:.|:||.:||..:.|.|.||:||.|.:.||::.|:|||..::.....::
  Fly   263 TTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVF 327

Human   326 IHAHNTIAIFQEAVHKQTSVAPRHQEYLFEG-HLCVLEPSVSAQHIAH----TTASSPLTLFS-- 383
            :.....|..|:|.:..||.|....|..||.. |   ||..|:.:.||.    ||...|:.|:|
  Fly   328 LEPDEQIDNFRERIFLQTEVPLEKQILLFNNEH---LEKKVTPRTIAKAFPATTTDQPIFLYSND 389

Human   384 ---TAIPKGLAFRDPALDVPK---FVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRG 442
               ..:|:       .||:||   |.|.|.::.|.:.||.....|::..|..........|:.:|
  Fly   390 DNNVQLPQ-------QLDLPKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSMDILIKKG 447

Human   443 LHWVMEVLQATCRRTLEVARTSLLYLSSSLG-TERFSSVA----GTPEIQELKAAAE-LRSRLRT 501
            :...:|:|..|....|:...:....||:.:. .:...|:|    |..||:.|..|.| ::|....
  Fly   448 VEHFIEMLVTTITLLLKKTESFDNLLSTVIDYADVVHSMARVTKGDQEIKTLLTALENVKSDFDG 512

Human   502 LAEVLSRCSQNITETQESLSSLNRELVKSRDQVH------EDRSIQQIQCCLDKMNFIYKQFKKS 560
            .|:|:|:..::.....|    ||.:...|   :|      :.|:..|.:..::::...::...:.
  Fly   513 AADVISQMHKHFVIDDE----LNDQWTSS---MHGKKCPCKTRASAQAKYLVERLRDSWQHLLRD 570

Human   561 RMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQE----------ECVQK-YQASLVTHGKRMRVV 614
            |....|.||:||.|.|:|:...|..||:..:..:          ||:.. |:.:...:.|...:.
  Fly   571 RATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLADWYKLAQTVYLKTQILE 635

Human   615 HETRNHLRLVGCSVAACNTEAQGVQESLSKLLEEL 649
            .:.|:           |..:..|:::.|..:..||
  Fly   636 KDVRD-----------CERKLNGIRDELYHVKSEL 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKBKE	NP_054721.1	Protein Kinases, catalytic domain	15..330	CDD:473864	183/314 (58%)
		Ubl_IKKE	308..385	CDD:340648	24/86 (28%)
		Interaction with DDX3X	383..647		61/294 (21%)
		TBK1_CCD1	400..646	CDD:465742	57/271 (21%)
		Leucine-zipper	436..457		5/20 (25%)
		TBK1_IKKE-like_C	675..715	CDD:425366
IKKepsilon	NP_610048.2	STKc_TBK1	18..332	CDD:270890	183/314 (58%)
		Ubl_TBK1_like	310..388	CDD:340518	23/80 (29%)
		TBK1_CCD1	405..656	CDD:465742	55/268 (21%)