Protein Alignment IKBKE and Y39G8B.5

DIOPT Version :10

• Sequence 1: NP_054721.1
• Gene: IKBKE / 9641
• HGNCID: 14552
• Length: 716
• Species: Homo sapiens
• Sequence 2: NP_496929.2
• Gene: Y39G8B.5 / 189764
• WormBaseID: WBGene00012726
• Length: 726
• Species: Caenorhabditis elegans
• Alignment Length: 767
• Identity: 171/767 - (22%)
• Similarity: 296/767 - (38%)
• Gaps: 192/767 - (25%)

Human     7 YLWHTDDLLGQGATASVYKARNKKSGELVAVKVF-NTTSYLRPREVQVREFEVLRKLNH-QNIVK 69
            |..:.|:.:.:||.:.||:.|. :||.|||||.. .|.|.....:....|.::|:||.. .|||:
 Worm    19 YTLYNDEFMAKGAYSQVYRGRT-ESGRLVAVKTARKTASNKADVDAMCTEIDILKKLKGVANIVQ 82

Human    70 LFAVEETGGSRQKVLV------MEYCSSGSLLSVLESPENAFGLPEDEFL-VVLRCVVAGMNHLR 127
            .|..:.|......|.:      || |:|.||.:.:..|||..|||.:..: :|:.|.:| ::.||
 Worm    83 YFGSKNTKIPPGSVTIETISFAME-CASRSLDAEMRRPENHKGLPSNVLIDLVVDCSMA-LSALR 145

Human   128 ENGIVHRDIK-------PGNIMRLVGEEGQSIYKLTDFGAARELDDD--EKFVSVYGTEEYLHPD 183
            |:.|.|||||       ||:..|  |.....::||.|.|.::.:.::  ::..|:.||:.:|:||
 Worm   146 EHNIAHRDIKHMNILLFPGSPTR--GRRSTHLFKLCDMGCSKAISENSSQELNSIAGTKTFLYPD 208

Human   184 -------MYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRIT--- 238
                   .::......|:|      .||||:|.|||..|||..||    ...|....:|.:.
 Worm   209 HIPPNGHNWKTKSAYTPEQ------CDLWSLGCTLYFCATGEFPF----ESTRADANLYHMAAVD 263

Human   239 -TEKPAGAIAGAQRRENG---------------PLEWS-YTLPITCQLSLGLQSQLVPILANILE 286
             |..|........:.||.               |.|:: |...:.|.::.        :|.|...
 Worm   264 LTRNPNAVAVNLVQVENPVTKEKVFNFEPVTELPAEFTRYPKWLVCTMTC--------LLRNFFH 320

Human   287 VEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQE 351
            ....      :::|:.:.:::......|    |.:..:.|..|..::...|      |..|...|
 Worm   321 EPSI------EYYAKVAGVMRNSKRRTF----ASVDQMSIVEHTDMSNILE------SSLPSISE 369

Human   352 YLF--EGHLCVLEPSVSAQHIAHTTAS---SPLTLF-----------STAIPKGLAFRD------ 394
            .|.  ||...||..:.|..::.....|   .|..|:           .|.:.:.:.|.:
 Worm   370 CLGYPEGIDIVLLANTSTHYLDSKQKSVDGLPDDLYLVLPQTSQVEMRTLLKRNIKFNELECMTD 434

Human   395 ---------PALDVPKFVPKVDLQAD-YNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEV 449
                     ...:....:.:||...| ::....:|...:..|        .|||.      ..|.
 Worm   435 TKLIEIRIKKCYEGLSMLTEVDEYLDLFDRVSAILSTQFSLL--------VQELS------QFER 485

Human   450 LQATCRRTLEVARTSL-LYLSSSLGTERFSSVAGTPEIQELKAAAELRSRLRTLAEV---LSRCS 510
            :|.|.|..:.|...|: :.|......|     |.|...|.::.|.:.|..|...|:|   ...|:
 Worm   486 VQTTSRFAVYVDMASVPMMLFDEANPE-----AKTIADQCIQQAIQAREELERHAKVAMDFEACA 545

Human   511 QNITETQESLSSLNRELVKSRDQVHE----DRSI---------QQIQCCLDKMNFIYKQFKKSRM 562
            :.::...|.|...:.:|...|.::..    |::.         :.::.||.:.|.:.||...|
 Worm   546 KKLSREAEDLRLEDMDLPGIRREIESYLFYDKATILSTQKYTQELVELCLKRRNTVMKQIFNS-- 608

Human   563 RPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQE------ECVQKYQASLVTHGKRMRVVHETRN-H 620
             |. |.|:.:::  ..:|.:....:|...:|:      |||...:       |..:|:.:..| :
 Worm   609 -PD-GINKSKLN--TAMNLAASLSQLRSDYQKLQDMISECVDLLE-------KPFQVMKDNVNRY 662

Human   621 LRLVGCSVAACNTEAQGVQ-----------------ESLSKLLEELSHQLLQ 655
            |:..|||   .||..:.:.                 :|..||:::|:.:|.|
 Worm   663 LQAQGCS---RNTMEKSMHLLRPEFHENQIRMKKSTKSCRKLIDQLNKELEQ 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKBKE	NP_054721.1	Protein Kinases, catalytic domain	15..330	CDD:473864	93/359 (26%)
		Ubl_IKKE	308..385	CDD:340648	17/92 (18%)
		Interaction with DDX3X	383..647		59/320 (18%)
		TBK1_CCD1	400..646	CDD:465742	56/287 (20%)
		Leucine-zipper	436..457		7/20 (35%)
		TBK1_IKKE-like_C	675..715	CDD:425366
Y39G8B.5	NP_496929.2	Protein Kinases, catalytic domain	25..263	CDD:473864	79/252 (31%)