Protein Alignment IKBKE and ikbke

DIOPT Version :10

• Sequence 1: NP_054721.1
• Gene: IKBKE / 9641
• HGNCID: 14552
• Length: 716
• Species: Homo sapiens
• Sequence 2: XP_031752733.1
• Gene: ikbke / 100487744
• XenbaseID: XB-GENE-994611
• Length: 718
• Species: Xenopus tropicalis
• Alignment Length: 725
• Identity: 412/725 - (56%)
• Similarity: 522/725 - (72%)
• Gaps: 21/725 - (2%)

Human     1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQ 65
            ||||.||||..||:|||||||||||||||||||.|||||||..|||||.|||:||||:||||||.
 Frog     1 MQSTPNYLWELDDVLGQGATASVYKARNKKSGEEVAVKVFNNLSYLRPLEVQMREFEMLRKLNHV 65

Human    66 NIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENG 130
            ||||||||||||.|:|||||||||||||||||||.||||:||.|.|||:||:||||||||||:||
 Frog    66 NIVKLFAVEETGNSKQKVLVMEYCSSGSLLSVLEDPENAYGLSEAEFLIVLQCVVAGMNHLRQNG 130

Human   131 IVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQ 195
            ||||||||||||||:||:|:||||||||||||||||||||:|:||||||||||:||||||:||||
 Frog   131 IVHRDIKPGNIMRLIGEDGRSIYKLTDFGAARELDDDEKFLSIYGTEEYLHPDIYERAVLKKPQQ 195

Human   196 KAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWS 260
            ||:||||||||||||.||||.|||||||:||||||||||::|.||||..||||.||:|.||:||.
 Frog   196 KAYGVTVDLWSIGVTFYHAACGSLPFIPYGGPRRNKEIMHKIITEKPPRAIAGVQRKEKGPIEWI 260

Human   261 YTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIY 325
            |.|||:|:||:||:..|..||.||||.:|.||||||:||:||::||:|:|||||||..|.:|.:|
 Frog   261 YELPISCRLSVGLKVHLENILPNILEADQEKCWGFDKFFSETNNILERIVVHVFSLPHATMHMVY 325

Human   326 IHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFST---AIP 387
            :.|.:::..|.|||.|||.||..:|:|.:|||...:.|::..:||..||...|..|.|:   .|.
 Frog   326 VLACSSVVNFMEAVSKQTGVAFENQKYFYEGHHYPMMPTLQVKHITGTTEQHPFILMSSTSDCIV 390

Human   388 KGLAFRDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQA 452
            |. .::||..|.|:|:|.||:.||.:.||.||.|.||.||:|||||..||.:.||.:|::|..:.
 Frog   391 KA-TYKDPTNDFPRFLPSVDVVADCSIAKNVLSAVYQTLRVARALLTCQEFILRGTYWLIENTKT 454

Human   453 TCRRTLEVARTSLLYLSSSLGTER-----FSSVAG-TPEIQELKAAAELRSRLRTLAEVLSRCSQ 511
            .|.:.||...|....|:.::.||.     ::||.. .||..|....||.|.:|:::...||.||
 Frog   455 ECHQILEKKSTMASLLNCTISTENRITRLYNSVNNRKPEFPEFPDLAECRRQLQSIGHTLSSCS- 518

Human   512 NITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKL 576
            :|.|.|..|..|:.|:.|::||:..|.||.:::.||.||..|:.||||.:.:..|||||||:|||
 Frog   519 HIVEKQNMLEFLSLEVSKNQDQIQLDTSINRMEYCLRKMQLIFNQFKKRKQQSRLGYNEEQLHKL 583

Human   577 DKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQES 641
            ||||..:|||::|.:||:..||||:|:|..|..||....:...|:.||.........:.|..|:|
 Frog   584 DKVNLGNLAKKVLAIFQDGVVQKYKAALDKHSNRMSTFADILKHVDLVNGYFGGSFLDLQKYQDS 648

Human   642 LSKLLEELSHQLLQDRAKGAQASPPPIAPYPS---PTRKDLLLHMQELCEGMKLLASDLLDNNRI 703
            ::..:::|:.::       .|.|.|..:|.||   ..::||.|.|.:|.:.||.::.:|..||.:
 Frog   649 VNNAVDDLTLRI-------QQMSEPNHSPLPSCHNQDKEDLTLRMLKLRDQMKTVSYELQQNNSV 706

Human   704 IERLNRVPAP 713
            ||||....:|
 Frog   707 IERLGVTSSP 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKBKE	NP_054721.1	Protein Kinases, catalytic domain	15..330	CDD:473864	250/314 (80%)
		Ubl_IKKE	308..385	CDD:340648	34/79 (43%)
		Interaction with DDX3X	383..647		109/272 (40%)
		TBK1_CCD1	400..646	CDD:465742	103/251 (41%)
		Leucine-zipper	436..457		7/20 (35%)
		TBK1_IKKE-like_C	675..715	CDD:425366	15/39 (38%)
ikbke	XP_031752733.1	Protein Kinases, catalytic domain	15..327	CDD:473864	249/311 (80%)
		Ubl1_cv_Nsp3_N-like	308..384	CDD:475130	33/75 (44%)
		TBK1_CCD1	402..651	CDD:465742	103/249 (41%)
		TBK1_IKKE-like_C	676..718	CDD:409261	15/41 (37%)