DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF592 and CG17612

DIOPT Version :9

Sequence 1:	NP_055445.2	Gene:	ZNF592 / 9640	HGNCID:	28986	Length:	1267	Species:	Homo sapiens
Sequence 2:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	120/560 - (21%)
Similarity:	190/560 - (33%)	Gaps:	181/560 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   583 PASGYC--CLECGD------------AFALEKSLSQHYG----RRSVHIEVLCTLCSKTLLFFNK 629
            ||.|.|  |||..|            ...:...|||:.|    :.....|.:|..|
  Fly   182 PAIGSCRVCLEQSDNLTNIFDDAHQYGIPIATILSQYTGMPVEKGDSFSEYICVTC--------- 237

Human   630 CSLLRHARD--HKSKGLVMQCSQLLVKPISADQMFVSAPVNSTAPAAPAPSSSPKHGLTSGSASP 692
            ..::::|.|  ...:..:....|...:.|..|    |.||.: .|.....:..|.|
  Fly   238 LDVVKNAFDDLESKENTIQMYRQPKEEIIDID----SIPVKN-KPVDYEVTGKPPH--------- 288

Human   693 PPPALPLYPDPVRLIRYSIKCLECHKQMRDYMVLAAHFQ---------RTTEETEGLTCQVCQML 748
                               :|.:|.|    ..:|||..|         ||||... |.|.:|..:
  Fly   289 -------------------RCPQCPK----IFLLAAKLQAHIRTHNETRTTEPPR-LKCPMCPSI 329

Human   749 LPNQCSFCAHQRIHAH--------KSPYCCPECGVL-CRSAYFQTHVKEN---CLHYARKVGYRC 801
            ...:....||..||..        :.||.||.|..| ..|::.:.|::.:   ....:||..::|
  Fly   330 YMKRGCLEAHMWIHRASDERESELEPPYRCPHCPKLFLYSSFLEIHIQTHEDVSQRLSRKSSHKC 394

Human   802 IHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQPHRPSQLIYKC-S 865
            ..|..|...::.||.|::....:...||..|.|:|:..|:...|..          :...:|| .
  Fly   395 AQCADVFSDVSSLKDHVKIHAGERTFKCPLCLMSFQEESNLKSHDC----------AHTRFKCHK 449

Human   866 CEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLLFVQKPELMQHVKSTHGVPRNVDELSSLQSS 930
            |...|..:.::..||.:  |.|..|.|||.:|...|.::..|.:|:.|...|       ..|:|.
  Fly   450 CSKFFESQNYLDFHFKK--SHTTKGPFKCIKCQQTFQKRNGLKEHISSQVCV-------QFLRSK 505

Human   931 ADTSSSRPGSRVPTEPPATSVAARSSSLPSGRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDR 995
            :      ||...|                                         |.:|.:.....
  Fly   506 S------PGQIFP-----------------------------------------CPKCPKKFSIE 523

Human   996 ESYVSH--MKKSHGRTLKRYPCRQCEQSFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRP 1058
            ::|..|  ..|.....::|:.|.||::|:.....|.|||.:::       .|.:|   |.||...
  Fly   524 DNYQMHHATHKKVKTVIERHNCTQCKKSYQNKKLLTKHILSHN-------RCVHC---SMSFTSK 578

Human  1059 SLLESH-------ISLMHGIRNPDL-------SQTSKVKP 1084
            .|||.|       ::...|.:||:|       |..|.::|
  Fly   579 YLLEQHTCSQSYQLNGSRGRKNPNLNYNECEESNESDLEP 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF592	NP_055445.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..153
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..280
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..488
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..696		2/22 (9%)
		C2H2 Zn finger	742..762	CDD:275368	4/19 (21%)
		C2H2 Zn finger	770..817	CDD:275368	13/50 (26%)
		C2H2 Zn finger	829..845	CDD:275368	5/15 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..970		5/51 (10%)
		C2H2 Zn finger	985..1006	CDD:275371	5/22 (23%)
		C2H2 Zn finger	1015..1036	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1045..1065	CDD:275368	9/26 (35%)
		zf-C2H2_11	1149..1177	CDD:293228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1195..1267
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	13/67 (19%)
		C2H2 Zn finger	290..310	CDD:275368	7/23 (30%)
		C2H2 Zn finger	323..343	CDD:275370	4/19 (21%)
		zf-C2H2_8	356..438	CDD:292531	22/81 (27%)
		C2H2 Zn finger	359..379	CDD:275368	6/19 (32%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		C2H2 Zn finger	422..438	CDD:275368	5/15 (33%)
		C2H2 Zn finger	447..463	CDD:275368	3/15 (20%)
		C2H2 Zn finger	476..505	CDD:275368	8/35 (23%)
		C2H2 Zn finger	513..533	CDD:275368	4/19 (21%)
		C2H2 Zn finger	545..565	CDD:275368	8/19 (42%)
		C2H2 Zn finger	568..584	CDD:275368	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7952
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950