Protein Alignment ARHGEF10 and CG43102

DIOPT Version :9

• Sequence 1: XP_024303103.1
• Gene: ARHGEF10 / 9639
• HGNCID: 14103
• Length: 1373
• Species: Homo sapiens
• Sequence 2: NP_001247156.1
• Gene: CG43102 / 42137
• FlyBaseID: FBgn0262562
• Length: 2519
• Species: Drosophila melanogaster
• Alignment Length: 1844
• Identity: 358/1844 - (19%)
• Similarity: 624/1844 - (33%)
• Gaps: 688/1844 - (37%)

Human     1 MRQSQLLLVGSPRAPSLNRAERGIWSCSMDQREPLPPAPA-------ENEMKYDTNNNEEEEGEQ 58
            :::.:.:...|| :|:.:|.|           |..||.|.       :.|:..:.|..:|   :.
  Fly   888 LKRDKAIEAPSP-SPTHSREE-----------EIAPPDPGWVRIPLKKTELSINLNYGQE---KS 937

Human    59 FDFDS-------GDEIPEADRQAPSAPETGGAGASEAPAPTGG-EDGAGAETTPVAEPTKLVLPM 115
            .|.|:       .:|:..:|......|....:....|.|.... .|...:||..:   .|..:|.
  Fly   938 LDHDAIQEEDIFSNELAASDSSGIVFPVATASSVIAAHATMESLTDTIQSETDCL---IKEDVPP 999

Human   116 KVNPYSVIDITP--------------FQEDQ-----PP-----------TPVP----SAEE---- 142
            .|.|  |::|||              ..|:|     ||           .|||    :|:|
  Fly  1000 PVQP--VVEITPPASSVSGSAPNLATLMEEQLPLEAPPDNFLQTATTCEIPVPVYECAAQEWLET 1062

Human   143 ----------ENVGLHVPCGYLVPVP---CGYA-VPSNLPLLLPAYSSPVIICATSLDEEAETPE 193
                      |..|: ||.....|:|   |..: .||.|...:.:...|.|..:.|.:|..|..:
  Fly  1063 PAQEWVEVAPEEFGI-VPETIQPPIPHAACKISQTPSTLTTAVRSDLVPTISVSRSSEEGDELAK 1126

Human   194 VTEDRQPNSLSSEEPPTSEDQVGREDS------------------ALARWAADPA---------- 230
            : ||.....:::....||.|:..||.|                  |..|.:.|..
  Fly  1127 I-EDEPQVEVATTARNTSMDRHIREYSQDDLDLANVDLRSSLEAIATPRHSTDERQRRHLDKSTK 1190

Human   231 -------NTAWM---ENPE------------EAIYDDVPRENSD-------SEPD-----EMIYD 261
                   |..|.   |.|:            .||..:.|..|:.       |.|.     |:...
  Fly  1191 RKGMYIDNADWQAPTEAPQRGLALDISVANLNAIKPESPEANTPGASQMYISSPQSSYSFELNTP 1255

Human   262 DVENGD----EGG--------------NSSLEYGWSSSEFESY---EEQSDSECKNGIPRSFLRS 305
            ::|.|.    .||              :||.|...:|....||   :..||:||...|     |.
  Fly  1256 ELEKGSPSWGSGGLVRDKAQLLSNFSCHSSEEKDDASCRSLSYLRTDSTSDNECDRAI-----RE 1315

Human   306 NHKKQLSHDLTRLKEHYEKK---MRDLMASTVGVVE--------------IQQLRQKHELKMQKL 353
            ..:::::...|.....|:.|   .|.|......::|              :::||:...|.::..
  Fly  1316 RERERITSSPTPSSGDYDYKRFSKRPLRGPYGQMLEAEMKKPNRMHFEEILEELRETDSLHLRGS 1380

Human   354 VKAAKDGTKDGLER------TRAAVKRGRSFI------RTKSLIAQ-DHRS-------------- 391
            ......|...|..|      ....|::..:|:      |..|..:| :|.|
  Fly  1381 APGVAAGGTVGPSRNLPQYSNSMRVRKTSTFLPVPSHARAASTPSQLEHASKGISAATAQISVSA 1445

Human   392 ------SLEEE----------------------QNLFIDVDCKH--------------------- 407
                  .|:::                      |::..:...:|
  Fly  1446 KNLSQAELDDQVHHMKRAASEAPAPKSNHSKRSQSMSTERPSQHHHHHGHGHGHSHGHHHAGKRS 1510

Human   408 ----------------------------------PEAILTPMPEGLSQQQV----------VRRY 428
                                              ..|:|..:.:|.|:..:          .|.|
  Fly  1511 LDAGSGDKAAKNAPLAGGTSGSGSGGGGKAGLKPTPALLAELLKGSSENMISEQRKKTIADTRTY 1575

Human   429 ILGSVVDSEKNYVDALKRILEQYEKPLSEME-PKVLSERKLKTVFYRVKEILQCHSLFQIALASR 492
            ::..:..:|::||::|:.::.:|.|.|...| ..::..|.:..:|:.|.:||:.|..|...|.||
  Fly  1576 VVQEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLSDLKSR 1640

Human   493 VSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDR 557
            :.:||..:.:||.|:.:|||..||:.|:.:|||.:.|...::.....:|:|.:||:........:
  Fly  1641 LDDWDVQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPSFSKFLETTAREHKGK 1705

Human   558 TTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLN--ER------KR 614
            .||.:|::||:|:||.:.||.|.::|:|...|||...||..|..:..:...:|  ||      :|
  Fly  1706 LTLDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVLKLVHDILVHINCKEREIMENGQR 1770

Human   615 DADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMC 679
            :|..| |::.:.:.|.:     |::...::|     :.:.|....|:..: |:|..|:.||:|:.
  Fly  1771 EATLR-ELEGVIEGITD-----LIAPERQFL-----LFDLVSMPSGQGAR-KDRGFFLFNDLLVL 1823

Human   680 ATVSSR------------PSHDSRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPP 732
            .::..|            |...:..:.:.:|.....:.|   |.:|
  Fly  1824 TSIKKRSGTIRKPNSSICPGTVATTLDTNKYKFLTKISL---DCLE------------------- 1866

Human   733 ESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQ 797
                 :..:|...:    .::..:::.|..|.|.:.|||.:...:|..:|.|
  Fly  1867 -----IVKSKDENI----KRIVSEIETLAEDCNKLQQITDITVTIKYPHQYL------------- 1909

Human   798 RLILKKEDEIRAADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMA-------- 854
                  ||.||... ..:|.||..:|                   ..::.:|.|::.
  Fly  1910 ------EDVIRELH-REVQRQLSERQ-------------------TNDTQLNMLELTVSSPNGNQ 1948

Human   855 KLAL---EEENHMGWFCVEDDGNHIKK------EKHPL--LVGHMPVMVAKQQEFKIECAAYNPE 908
            |||:   :.|....|   |:..|..|:      |:||:  .:..:|:...: ...:..|||..
  Fly  1949 KLAVVFSKTEKRTQW---EESFNEAKQKLAATLERHPIPEFLTSIPIRKTR-AGLQFTCAAAT-- 2007

Human   909 PYLNNESQPDSFSTAHGFLWIGSCTHQMGQIAIVSFQNSTPKVIECFNV-ESRILCMLYVPV--- 969
              |::...          :|:.:....:||:.|:|. :..|.|..|..| .:||||:..||.
  Fly  2008 --LSDNRD----------VWVCNSDGYVGQVCIMSL-HPEPNVTSCNGVCNARILCVASVPAYSS 2059

Human   970 --------------------EEKRREP-------------------------------------- 976
                                ::||..|
  Fly  2060 AASSRNSSSEQPAGSGGQEEKDKRHTPQSYTQQLRDYRKSISPSFQSASASATATPEKKKLTPTP 2124

Human   977 ----GAPP--------------------DPETPAVRAS-------------DVP----------- 993
                |..|                    |.||.|..||             .||
  Fly  2125 TPVAGGEPADAATTGGSDTQLELNLSSSDDETEAAAASLNVAGSTGSTLVERVPSPAPSYHGHQD 2189

Human   994 -----------TICVGTEEGSISIYKSSQG----SKKVRLQHFFTPEKSTVMSLACTSQSLYAGL 1043
                       |:.:|||:|.|.:|.|:..    ..:::::|     .|.|.|:......::..|
  Fly  2190 SNPEEGESNQSTMWIGTEDGCIHVYNSTDNIRIKKNRIKIEH-----HSAVYSILYLDNRVFVSL 2249

Human  1044 VNGAVASYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASGGQVFIISVETHAVEGQL 1106
            .||.:..|.|....||::.....:.:|.:  ||..||.:...||.:..|.:.::.|||..|..|:
  Fly  2250 ANGDICVYLRDGATSWNTCSSHCLSIGTVTSPVNKLLNVNGRLWCSIQGIIKVLDVETLTVVNQI 2314

Human  1107 EAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPG-------HQ 1164
            :. ..:...|::|.||...:||:..:.:.::.||:.|.:.:.::|:|..|:.||..       |:
  Fly  2315 QI-SSDSKPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNKMLSNCDEIIRQHK 2378

Human  1165 R--LSVTSLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSY------HAHNSPVKFI-- 1219
            .  |.|||||.|..|:.:|||.|||:.:|.   ||..|    |.::.      |.|...|:|:
  Fly  2379 AACLRVTSLLCCKDLIWIGTSAGVLLTIPA---QGYEK----GAINIVPTGIPHGHTGHVRFLTF 2436

Human  1220 VLATALHEKDKDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSD 1284
            |..|.|                        :...||..|              |...||  ..||
  Fly  2437 VETTGL------------------------EGAASGAGG--------------GRDAGS--SNSD 2461

Human  1285 LSSSSGSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHR 1349
            ..:..|  |:.|..|                             |::.::.|::.||.|:.....
  Fly  2462 EYTKQG--SIKHSKS-----------------------------KSETNNTLIISGGDGYEDFRN 2495

Human  1350 KARQ-----PHQEELAPTVMVWQI 1368
            ....     ..:|:....:::|||
  Fly  2496 SGANSLSEIAGREDSTNHLLIWQI 2519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGEF10	XP_024303103.1	PTZ00441	<27..278	CDD:240420	78/397 (20%)
		RhoGEF	426..610	CDD:238091	58/184 (32%)
		PH-like	643..>707	CDD:327399	12/75 (16%)
CG43102	NP_001247156.1	RhoGEF	1576..1758	CDD:279015	56/181 (31%)
		PH-like	1750..>1889	CDD:302622	26/181 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3522
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D43489at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5001
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850