DRSC/TRiP Functional Genomics Resources

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Protein Alignment FEZ1 and Unc-76

DIOPT Version :10

Sequence 1:NP_005094.1 Gene:FEZ1 / 9638 HGNCID:3659 Length:392 Species:Homo sapiens
Sequence 2:NP_569981.1 Gene:Unc-76 / 31179 FlyBaseID:FBgn0040395 Length:474 Species:Drosophila melanogaster


Alignment Length:415 Identity:128/415 - (30%)
Similarity:195/415 - (46%) Gaps:122/415 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    38 LEDPSLS---ELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEET 99
            ||..||:   .::||:.....  |:|||||.||||:..||.||....|.||||    |::.:||.
  Fly   122 LEKRSLAVGDHVDNFTETFGG--SLEDLVNTFDEKITKCFGNYEENVEELAPV----QVRSQEEI 180

Human   100 LQDEEVWDALTDNYIPSLSEDW-----RDPNIEALNGNCSDT-----------EIHEKEE----- 143
            :.:.::|..:|.|:...|..||     |..::..||...:.|           ::|.:..     
  Fly   181 MNECQMWWTITGNFGNILPIDWSKSYTRQMHMPTLNLGQNHTKQQQQNRNQQQQLHNQSHQAYPH 245

Human   144 ------------------EEFNEKSEND--------------SGIN----EEPLLTADQVIEEIE 172
                              :|||:.:..|              :|:|    ::|:.|.::||:||:
  Fly   246 TNGLGSGSGSGLDAQTPGDEFNDLTSEDEAVANDLDMHALILNGLNGDMDDQPIKTVEEVIKEID 310

Human   173 EMMQNSPDPEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLD 237
            ::|..:..|.:|.|..:    .|...:|..||...:.|           |.|::::.::|.||..
  Fly   311 DIMDEAESPLDEPETCD----SEVIEKAREVLGAPLYA-----------EKLQYLTTTQLNELYM 360

Human   238 QVEGAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQSS 302
            ::|..|::.||.|:.:||.|||||||||:|||||::|:.||||:: |..:.|||.|         
  Fly   361 EMEVLIQELSETLINELALRDELEFEKELKNSFISLLLAVQNKRR-QYHVEKKRGK--------- 415

Human   303 RIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDLQMLTNIL 367
                                           ..|.:.:||.|||||..:...|:.:.||:|..||
  Fly   416 -------------------------------FQGPEPKYLTTVIPYHLENGTPNNQSLQVLIKIL 449

Human   368 FAMKEDNEKVPTLLTDYILKVLCPT 392
            .|:.||:..||.|||||||||||||
  Fly   450 KAINEDSPTVPALLTDYILKVLCPT 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FEZ1NP_005094.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
FEZ 58..297 CDD:462257 90/295 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 175..198 5/22 (23%)
Unc-76NP_569981.1 FEZ 143..418 CDD:462257 90/334 (27%)
Blue background indicates that the domain is not in the aligned region.

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