DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TESMIN and mip120

DIOPT Version :9

Sequence 1:	XP_011543704.1	Gene:	TESMIN / 9633	HGNCID:	7446	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_001163143.1	Gene:	mip120 / 36499	FlyBaseID:	FBgn0033846	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	143/540 - (26%)
Similarity:	223/540 - (41%)	Gaps:	129/540 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    56 PADPKEPVLHAFNPALGADCKGQVKAKLAGGDSD-------GGELLGEYPGIPELSALEDVALLQ 113
            ||....|.......|..|......||.||.|:::       ||.:: ..|.:..|.:...:..:.
  Fly   437 PAATGVPATSTTTSAAAASPAAASKANLAMGNTNKIVMRSMGGSIV-PLPSVQTLVSKRALGAIS 500

Human   114 APQPPACNVHFLSSLLPA--------HRSPAVLPLGAWVLEGASHPGVRMIPVEIKEAGGTTTSN 170
            ....||....  ||..|:        ||   :..|...:.:.||          :......::..
  Fly   501 NASKPASAAS--SSATPSASQELPRKHR---LTDLNVQLKQSAS----------VSSEASDSSDA 550

Human   171 NPEEATLQNLLAQESCCKFPSSQELE-----------------DASCCSLKKDSNPMVICQLKGG 218
            .||....:.::..:...:..:||.::                 ..|..|.||..|.:......|.
  Fly   551 GPEAKKPRYVITMQQGSQKAASQPVQKLINRTANVQRVVSSSTSPSSNSTKKIYNYVQPTGSNGA 615

Human   219 TQMLC---IDNSRTRELKALHLVPQYQDQNNYLQSDV--PKPMTALVGRF-------------LP 265
            ..|:|   :..|.|..::        :....|:::..  |.|::....||             |.
  Fly   616 KYMICNSGVPQSSTSAMR--------RGYTGYVENKTRRPPPISPQQHRFKQMGPQQQSKHQQLQ 672

Human   266 ASTKLNLITQQL----------EGALPSV-----VNGSAFPSGSTLPGPPKITLAG--------- 306
            |..|..:..|||          |..||::     .|..|.|....|..|.....||
  Fly   673 AQAKQRIRQQQLPTEQSTPIKVEPKLPTLPPGVKANVPAKPLFEVLKPPATAAAAGAVDPLGGMT 737

Human   307 ----------------YCDCFASGDFCNNCNCNNCCNNLHHDIERFKAIKACLGRNPEAFQPKIG 355
                            ||||||:|:||.:|.|.:|.|||.:::||.:||::||.|||.||:|||.
  Fly   738 SRRKHCNCSKSQCLKLYCDCFANGEFCQDCTCKDCFNNLDYEVERERAIRSCLDRNPSAFKPKIT 802

Human   356 KGQLGNVKPQHNKGCNCRRSGCLKNYCECYEAQIMCSSICKCIGCKNYEESPERKTLMSMPNYMQ 420
            ....|::: .|||||||:||||||||||||||:|.|||||||:||:|.|:.|:    :.|.:...
  Fly   803 APNSGDMR-LHNKGCNCKRSGCLKNYCECYEAKIPCSSICKCVGCRNMEDRPD----VDMDSLDG 862

Human   421 TGGLEGSHYLPPTKFSGLPRFSHDRRPSSCISWEVVEATCACLLAQGEEAEKEHCSKCLAEQMIL 485
            ..|:||.     .|.....:..::.|.:...:.:|:|||..|::::....||::.:....|:.::
  Fly   863 LMGVEGQ-----KKDKAKNKQLNENRANIYFTDDVIEATIMCMISRIVMHEKQNVAVEDMEREVM 922

Human   486 EEFGS-----VGHLEGVQET 500
            ||.|.     :...:..|||
  Fly   923 EEMGESLTQIIAFAKEKQET 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TESMIN	XP_011543704.1	TCR	367..404	CDD:281618	31/36 (86%)
mip120	NP_001163143.1	TCR	740..775	CDD:281618	12/34 (35%)
mip120	NP_001163143.1	TCR	813..850	CDD:281618	31/36 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155637
Domainoid	1	1.000	82	1.000	Domainoid score	I8420
eggNOG	1	0.900	-	-		E1_KOG1171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42302
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12446
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.800