DRSC/TRiP Functional Genomics Resources

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Protein Alignment NUP155 and Nup154

DIOPT Version :9

Sequence 1:NP_705618.1 Gene:NUP155 / 9631 HGNCID:8063 Length:1391 Species:Homo sapiens
Sequence 2:NP_001285827.1 Gene:Nup154 / 34527 FlyBaseID:FBgn0021761 Length:1365 Species:Drosophila melanogaster


Alignment Length:1422 Identity:474/1422 - (33%)
Similarity:747/1422 - (52%) Gaps:151/1422 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    37 DRMYPDLSELLMVSAPNNPTVSGMSDMDYPLQGPGLLS---VPNLPEISSIRRVPLPPELVEQFG 98
            :|..|.|.||..||.....|:||::|.||  |....|.   ..||.::.::.:..:|.|::|.|.
  Fly    25 ERNKPGLLELTGVSQHGRATMSGLNDYDY--QSLSFLKSDRTHNLQQMRTVTKSAIPNEILEHFK 87

Human    99 HMQCNCMMGVFPPISRAWLTIDSDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQPHVRH 163
            |::|:|.||:||.|.||||||||:|::|.:....|:||:||||..|::|||||||.|:|...|::
  Fly    88 HIKCHCTMGLFPEIGRAWLTIDSEIYIWTFNQTRDVAYYDGLSHLIVSVGLVKPKPGVFVQDVKY 152

Human   164 LLVLATPVDIVILGLSYANLQTGSGVLNDSLSGGMQLLPDPLYSLPTDNTYLLTITSTDNGRIFL 228
            ||||.||:::::||:::     |....|:     |||:..|::.:.|||..:..|..||:|||||
  Fly   153 LLVLTTPIEVIVLGVTF-----GESSYNE-----MQLMNRPVFVIGTDNVSISVIKGTDDGRIFL 207

Human   229 AGKDGCLYEVAYQAEAGWFSQRCRKINHSKSSLSFLVPSLLQFTFSEDDPILQIAIDNSRNILYT 293
            .|:||||||:.||||:.||.:||:|||.|:..:|::|||.|: .|||.|||..|.|||||.:||.
  Fly   208 GGRDGCLYEIYYQAESSWFGKRCKKINLSQGLVSYMVPSFLK-VFSEVDPIEHIEIDNSRKLLYV 271

Human   294 RSEKGVIQVYDLGQDGQGMSRVASVSQNAIVSAAGNIARTIDRSVFKPIVQIAVIENSESLDCQL 358
            .:|||||:.:|:........|:..::||.|.:.|.::..|:|.|:||.:..|..:...::....|
  Fly   272 LTEKGVIEAWDISTSYTTARRLGRITQNDITNQAVSLITTVDPSIFKSVKAICPLSADDADKLHL 336

Human   359 LAVTHAGVRLYFST--------------C----------PFRQPLARPNT-----LTLVHVRLPP 394
            :|||..||||:|||              |          |..||...||.     |.|:||||||
  Fly   337 VAVTQCGVRLFFSTTSLNVKQQFGPAVPCSPGENTGFGQPAVQPPLSPNAEAPKGLYLLHVRLPP 401

Human   395 GFSASSTVEKPSKVHRALYSKGILLMAASENEDNDILWCVNHD---TFPFQKPMMETQMTAGVDG 456
            |::.::|..||.:||.|.|::|.:||..::..:.|:||.::..   .|.:   ::|:.....:||
  Fly   402 GYTPNATTNKPKQVHAAHYTEGTMLMITTQQHEQDLLWSLSSAPSVNFTY---LVESTALESLDG 463

Human   457 HSWALSAIDELKVDKIITPLNKDHIPITDSPVVVQQHMLPPKKFVLLSAQGSLMFHKLRPVDQLR 521
            ..|.|:.:.|..     ||..|       ||:...:|   .:|..||:.||:.:...|:.||.||
  Fly   464 VVWGLAEVHEPS-----TPQRK-------SPLNSARH---ARKVALLTNQGTHIIEVLKMVDVLR 513

Human   522 HLLVSNVGGDGEEIERFFKLHQEDQACATCLILACSTAACDREVSAWATRAFFRYGGE------- 579
            .:|:|..|...||::.||:...:.:||.|.|:||.|......:|:.||.:||..||||       
  Fly   514 QILLSCNGPHHEEVKMFFQSQNQREACVTALLLATSDTYRGSDVALWAAQAFMLYGGEPCYQHQK 578

Human   580 ------AQMRFPTTLPPPSNVGPILGSPVYSSSPVP---SGSP--YPNPSFLGTPSHGIQPPAMS 633
                  ..|...|..|..:||..  ...::.|:|:|   :.||  :|...|             :
  Fly   579 FLNASNRNMANQTLGPNTTNVRE--RQSMFMSTPMPNSVANSPVGFPGSQF-------------N 628

Human   634 TPVCALGNPATQATNMSCVTGPEIVYSGKHNGICIYFSRIMGNIWDASLVVERIFKSGNREITAI 698
            .|:..:||.......:|....| ||:|.||:|:.:|.||::.::|....|        |.:..:.
  Fly   629 QPISPIGNMQPPQVAVSNENSP-IVFSAKHDGLYMYVSRMLHSVWQMRCV--------NEQFCSN 684

Human   699 ESSVPCQLLESVLQELKGLQEFLDRNSQFAGGPLGNPNTTAKVQ-----QRLIGFMRPENGN--- 755
            .|...|.||   |.:|:.|:.||:.:|      :.:.::|.:|.     .|...:.....||   
  Fly   685 LSQSECALL---LSDLRSLRSFLEVHS------VHDISSTTRVSFDNHLDRTNSYNTIMMGNTLL 740

Human   756 PQQMQQELQRKFHEAQLSEKISLQAIQQLVRKSYQALALWKLLCEHQFTIIVAELQKELQEQLKI 820
            |...|:.|.   .:||:.|..||.|:...|:.:.:.::||.:|..|.|.:|..:|..|.|:.|..
  Fly   741 PIPEQRVLS---EQAQVEETRSLSALNLFVKHACEVISLWNILNSHSFQLICVQLSPEHQKLLTC 802

Human   821 TTFKDLVIRDKELTGALIASLINCYIRDNAAVDGISLHLQDICPLLYSTDDAICSKANELLQRSR 885
            :||:||:|...|:...||.||||.|::|.|.|..:|.:|::.||.||..:|.:..||.|||..::
  Fly   803 STFRDLLITRSEVCAFLIISLINLYLKDAAGVSEVSKNLRENCPNLYRHEDDVTYKATELLMNAK 867

Human   886 QVQNKTEKERMLRESLKEYQKISNQVDLSNVCAQYRQVRFYEGVVELSLTAAEKKDPQGLGLHFY 950
            ...:.||||.|||.:|...::.:..:.|.::|.|:....|:|||:|||...|.|.||:.:|:|||
  Fly   868 NCTSATEKEHMLRTTLHMCKEAAPTLPLHSICMQFISADFFEGVIELSAVCASKSDPEEVGVHFY 932

Human   951 KHGEPEEDIVGLQAFQERLNSYKCITDTLQELVNQ--SKAAPQSPSVPKKPGPPVLSSDPNMLSN 1013
            .:|||.:|..|...|..|:..||.:...|..:..:  :|...|..|:....|....|...|    
  Fly   933 NNGEPADDREGYTCFATRMAYYKEVQLMLDHIYQRVCNKTHVQDKSINPLKGTAKASDAKN---- 993

Human  1014 EEAGHHFEQMLKLSQRSKDELFSIALYNWLIQVDLADKLLQVASPFLEPHLVRMAKVDQNRVRYM 1078
             .|.....:::..:.:.||.|..|.||.||:..|:..:||.|..|.|...|.|....:.:.|..:
  Fly   994 -GATQTIPKIVAHTLKVKDPLIHITLYEWLLAHDMLKELLDVVEPSLGEFLRRSVSQNVDNVVLI 1057

Human  1079 DLLWRYYEKNRSFSNAARVLSRLADMHSTEISLQQRLEYIARAILSAKSSTAISSIAADGEFLHE 1143
            ||||:|||||...|.||.:|..||...|..|:|:||:||:.||::..::....||: ::|.||.|
  Fly  1058 DLLWKYYEKNSHHSQAAHILDNLAMTRSENINLEQRIEYLVRAVMCMRNGNVGSSL-SNGIFLKE 1121

Human  1144 LEEKMEVARIQLQIQETLQRQYSHHSSVQDAVSQLDSELMDITKLYGEFADPFKLAECKLAIIHC 1208
            ||:|:::||:|..:...:....|.......||.:|:..|.|||:||..||:||.|.||:|:|::|
  Fly  1122 LEDKLDIARVQKSVLAAMTELASDKLEAATAVKELNYALYDITQLYQHFAEPFDLWECQLSILNC 1186

Human  1209 AGYSDPILVQTLWQDIIEKELSDSVTLSSSDRMHALSLKIVLLGKIYAGTPRFFPLDFIVQFLEQ 1273
            :.::||:|::::|..||...:....|  :|:|.:.|..||.:|.:.|..:...||..|:::.||.
  Fly  1187 SHHNDPLLIESVWGQIINSVVDKPGT--TSERCNRLFTKIEILVREYGESGVCFPFAFLIRELEV 1249

Human  1274 QVCTLNWDVGFVIQTMNEIGVPLPRLLEVYDQLFKSRDPFWNRMKKPLHLLDCIHVLLIRYVENP 1338
            :.|.|.:..|.|.:.:..:.:.:..|||.|.::....:..|.......||:..:..::....:|.
  Fly  1250 KACQLRFPEGIVPEKLVSMNLDIELLLEYYSRMISMNERVWANEGNEWHLIQSVIRVVSLLADNA 1314

Human  1339 SQVLNCERRRFTNLCLDAVCGYLVELQSMSSSVAVQ-----AITGNFKSLQAKLERL 1390
            ..:....:||......|.|.|.|        ::..|     .:..:.|.||::|:||
  Fly  1315 QSIWYRSKRRIVGKAQDIVAGCL--------NICYQKPDTNRLQHSLKELQSQLQRL 1363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NUP155NP_705618.1 Nucleoporin_N 77..507 CDD:400932 177/461 (38%)
NUP170 89..1311 CDD:227624 440/1281 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 985..1012 6/28 (21%)
Nup154NP_001285827.1 Nucleoporin_N 66..502 CDD:312364 179/464 (39%)
Nucleoporin_C <1018..1139 CDD:308677 49/121 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147845
Domainoid 1 1.000 322 1.000 Domainoid score I1227
eggNOG 1 0.900 - - E1_COG5308
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H43155
Inparanoid 1 1.050 742 1.000 Inparanoid score I590
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55643
OrthoDB 1 1.010 - - D140051at2759
OrthoFinder 1 1.000 - - FOG0004471
OrthoInspector 1 1.000 - - oto88639
orthoMCL 1 0.900 - - OOG6_102040
Panther 1 1.100 - - LDO PTHR10350
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R808
SonicParanoid 1 1.000 - - X3168
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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