Protein Alignment SNCAIP and sncaip

DIOPT Version :10

• Sequence 1: NP_001295029.1
• Gene: SNCAIP / 9627
• HGNCID: 11139
• Length: 1016
• Species: Homo sapiens
• Sequence 2: NP_001107108.1
• Gene: sncaip / 796993
• ZFINID: ZDB-GENE-080204-71
• Length: 738
• Species: Danio rerio
• Alignment Length: 973
• Identity: 421/973 - (43%)
• Similarity: 529/973 - (54%)
• Gaps: 251/973 - (25%)

Human     1 MEAPEYLDLDEIDFSDDISDNRSQGNRLQKLGLEDTDREDAMGFGSHRAKLTVVAALGACHCPEN 65
            |:.|||||||||||:||:.
Zfish     1 MDVPEYLDLDEIDFTDDLP---------------------------------------------- 19

Human    66 EYSVTSLKTIPELCRRCDTQNEDRSVSSSSWNCGISTLITNTQKPTGIADVYSKFRPVKRVSPLK 130
                .|.|:|||||||.|.||::|...:.:|....::......||||||||||||||||||||||
Zfish    20 ----YSSKSIPELCRRHDGQNDERQALAINWPRSAASHSGAGLKPTGIADVYSKFRPVKRVSPLK 80

Human   131 HQPETLENNESDDQKNQKVVEYQKGGESDLGPQPQELGPGDGVGGPPGKSSEPSTS--------L 187
            ||||..:.....:.|:         .|:|.               |.|| .|||.|        .
Zfish    81 HQPEETQTQTETEGKS---------SETDT---------------PSGK-EEPSKSRGLINQALF 120

Human   188 GELEHYDLDMDEILDVPYIKSSQQLASFTKVTSEKRILGLCTTINGLSGKACSTGSSESSSSNMA 252
            ||||||||||||||||||||.:||.|:..:..|              :|...:...|||.||. .
Zfish   121 GELEHYDLDMDEILDVPYIKCTQQAATLPRAPS--------------AGNTHTLVHSESLSSG-T 170

Human   253 PFCVLSPVKSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFLNKTFSDPHGRK 317
            .|||||||    :||:.:.......|..|.|....|..|.|:                ...|..:
Zfish   171 QFCVLSPV----MRKSKSADLRAQSLGFENTHEQIPDSKTGA----------------DGGHASR 215

Human   318 VEKTTPDCQLRAFHLQSSAAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLP 382
                                     :|..|::|       |..|..||.::|||||::|||||||
Zfish   216 -------------------------KQARGVSR-------EVDEEAKKSQNILNIVRDGQISLLP 248

Human   383 HLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLEC 447
            |.||:||:.|.||:||||||::|:|||.:||||||||||||||||||.::||||||:::||.|||
Zfish   249 HFAAENLELIRDEDGNNLLHVSAAQGHTDCLQHLTSLMGEDCLNERNKQQLTPAGLSVRNGHLEC 313

Human   448 VRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVAS 512
            ||||||||||||||||:::.|||||||..||||::|||||||||||.|||||.||:||||||||:
Zfish   314 VRWMVSETEAIAELSCTREHPSLIHYAARYGQERVLLWLLQFMQEQAISLDEQDQNGNSAVHVAA 378

Human   513 QHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLK 577
            |.|:|||:|||||||:|||:||...|:.||.|||||||.|||||||||||||||||||||||||.
Zfish   379 QFGHLGCLQTLVEYGSNVTVQNQQCERASQCAERQGHTTCSRYLVVVETCMSLASQVVKLTKQLH 443

Human   578 EQTVERVTLQNQLQQFLEAQKSEGKSLPSSPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGI 642
            |||..||.||||||..|:.|:..|:  |.|||....|:         |:..:....::...:.|.
Zfish   444 EQTTARVALQNQLQLLLQTQEPNGR--PPSPSCRVPPS---------DSWPEMTLTAEVAPENGQ 497

Human   643 QVLGSLSASSRARPKAKDEDSDKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNS------KK 701
            .||           |.|..::|.::|:||.|:.:|....::.     .||.|.|...      |:
Zfish   498 WVL-----------KQKHTETDGVMRKLLTKDAAERTHPRDT-----HDAGAESGAGPGAGPMKR 546

Human   702 IPL-EKRELKLARLRQLMQRSLSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLH 765
            :.: |:||||||||:|:|||||||||.|....::.|     ...||...||.|:.|
Zfish   547 LGVGERRELKLARLKQIMQRSLSESDGDVYPPDETK-----HMSRPTQLPIPEAEE--------- 597

Human   766 LMIKKHTLASGGRRFPFSIKASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSP 830
               .|:|.:|..|:..|:.:.|||:|..:|||:|:.|:|:..::
Zfish   598 ---PKNTHSSSERKLSFTHRTSKSVDACNPSPSSDQSDPETRTE--------------------- 638

Human   831 DSTAAQKVATSPKSALKSPSSKRRTSQNLKLRVTFEEPVVQMEQPSLELNGEKDKDKGRTLQRTS 895
               |..||.||||||||||||:|:|||||||||||:||            ..||...|.|  :..
Zfish   639 ---AGDKVTTSPKSALKSPSSRRKTSQNLKLRVTFDEP------------PRKDGAAGDT--KAP 686

Human   896 TSNESGDQLKRPFGAFRSIMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRKTDAKGNPASSA 958
            ::.|     ||||||||||||||||||||||:..:::..:       |.|:.|..|....:||
Zfish   687 STKE-----KRPFGAFRSIMETLSGNQNNNNSNSSSSNAQ-------SPGKHTGKKSKSKTSA 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNCAIP	NP_001295029.1	ANKYR	<369..556	CDD:440430	142/186 (76%)
		ANK repeat	396..429	CDD:293786	26/32 (81%)
		ANK repeat	431..501	CDD:293786	54/69 (78%)
		ANK repeat	503..534	CDD:293786	23/30 (77%)
		SNCAIP_SNCA_bd	559..602	CDD:435527	31/42 (74%)
sncaip	NP_001107108.1	ANKYR	<235..422	CDD:440430	142/186 (76%)
		ANK repeat	262..295	CDD:293786	26/32 (81%)
		ANK repeat	297..367	CDD:293786	54/69 (78%)
		ANK repeat	369..400	CDD:293786	23/30 (77%)
		SNCAIP_SNCA_bd	425..469	CDD:435527	32/45 (71%)