Protein Alignment SNCAIP and Sncaip

DIOPT Version :10

• Sequence 1: NP_001295029.1
• Gene: SNCAIP / 9627
• HGNCID: 11139
• Length: 1016
• Species: Homo sapiens
• Sequence 2: NP_001186080.1
• Gene: Sncaip / 67847
• MGIID: 1915097
• Length: 965
• Species: Mus musculus
• Alignment Length: 1017
• Identity: 827/1017 - (81%)
• Similarity: 878/1017 - (86%)
• Gaps: 53/1017 - (5%)

Human     1 MEAPEYLDLDEIDFSDDISDNRSQGNRLQKLGLEDTDREDAMGFGSHRAKLTVVAALGACHCPEN 65
            |||||||||||||||||||
Mouse     1 MEAPEYLDLDEIDFSDDIS---------------------------------------------- 19

Human    66 EYSVTSLKTIPELCRRCDTQNEDRSVSSSSWNCGISTLITNTQKPTGIADVYSKFRPVKRVSPLK 130
             ||||||||||.||||||:||||||||||.||||:||||||.|||||||||||||||||||||||
Mouse    20 -YSVTSLKTIPALCRRCDSQNEDRSVSSSGWNCGVSTLITNPQKPTGIADVYSKFRPVKRVSPLK 83

Human   131 HQPETLENNESDDQKNQKVVEYQKGGESDLGPQPQELGPGDGVGGPPGKSSEPSTSLGELEHYDL 195
            ||||||||||::|||| ..||||||||:|.||||:||.|.|||||.|||.||||.:|||||||||
Mouse    84 HQPETLENNENEDQKN-NTVEYQKGGETDQGPQPEELSPEDGVGGLPGKGSEPSQALGELEHYDL 147

Human   196 DMDEILDVPYIKSSQQLASFTKVTSEKRILGLCTTINGLSGKACSTGSSESSSSNMAPFCVLSPV 260
            ||||||||||||||||||..||||||||||||||||||||.|.|...|:|:|:.||.||||||||
Mouse   148 DMDEILDVPYIKSSQQLAPLTKVTSEKRILGLCTTINGLSAKTCPIASTENSTPNMTPFCVLSPV 212

Human   261 KSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFLNKTFSDPHGRKVEKTTPDC 325
            ||||||||...:.||||||||::|.||.|.|||.|||.||.|||||||.|||||.||:||:.|||
Mouse   213 KSPHLRKAPTALRDQHKLSTEDSESSPALGKCGPAYESENHSKDFLNKVFSDPHSRKIEKSGPDC 277

Human   326 QLRAFHLQSSAAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAADNLD 390
            :||:||||||||.:|.||.::|:|.|::||.|||:||||||:||||||.||||||||||||||||
Mouse   278 KLRSFHLQSSAAGAKTEEPINGMNWTNTQGTEERTEYLKKVRSILNIVNEGQISLLPHLAADNLD 342

Human   391 KIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSET 455
            ||||||||||||||||:||||||||||||||||||||||||:|||||||||||||||||||||||
Mouse   343 KIHDENGNNLLHIAASKGHAECLQHLTSLMGEDCLNERNTEQLTPAGLAIKNGQLECVRWMVSET 407

Human   456 EAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCI 520
            ||||||||||||||||||||||||||||||||||||||||||||||::|||||||||||||||||
Mouse   408 EAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDREGNSAVHVASQHGYLGCI 472

Human   521 QTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKEQTVERVT 585
            ||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||
Mouse   473 QTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYLVVVETCMSLASQVVKLTKQLKEQTVERVT 537

Human   586 LQNQLQQFLEAQKSEGKSLPSSPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSA 650
            ||:||||.|||||||||||||||||||||||.|||||:.|.|::|..|||.|.|||||||||||.
Mouse   538 LQSQLQQLLEAQKSEGKSLPSSPSSPSSPASTKSQWKALDTDEESTGKSKVGAQEGIQVLGSLSV 602

Human   651 SSRARPKAKDEDSDKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKRELKLARLR 715
            |||||.|.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   603 SSRARTKGKDEDSDKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKRELKLARLR 667

Human   716 QLMQRSLSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRF 780
            |||||||||||||||||||||.|||::||||||||||||||::|||||||||||||:||| ||||
Mouse   668 QLMQRSLSESDTDSNNSEDPKNTPVKRADRPRPQPIVESVENVDSAESLHLMIKKHSLAS-GRRF 731

Human   781 PFSIKASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDSTAAQKVATSPKSA 845
            ||.:||||||||||||||||||||||:|..||.|..||.|||.:..|.|||||||||||||||||
Mouse   732 PFGMKASKSLDGHSPSPTSESSEPDLDSHGPGLGMTPPTQPSTEATQSSPDSTAAQKVATSPKSA 796

Human   846 LKSPSSKRRTSQNLKLRVTFEEPVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGDQLKRPFGA 910
            |||||||||||||.|||||||||||||||..|||||||||||||..||||   |||:|:|||||.
Mouse   797 LKSPSSKRRTSQNSKLRVTFEEPVVQMEQTGLELNGEKDKDKGRAPQRTS---ESGEQMKRPFGT 858

Human   911 FRSIMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRKT-DAKGNPASSASKGKNKAEMYSSCINL 974
            ||||||:||||||||||||.|:||||.||||||||||| ||||||.|.||||||||.||||||:|
Mouse   859 FRSIMESLSGNQNNNNNYQPASQLKTCTLPLTSLGRKTADAKGNPVSPASKGKNKAAMYSSCIHL 923

Human   975 SSNMLIEEHLCNDTRHNDINRKMKKSYSIKHIAEPESKELFL 1016
            .||.|:||||.:..|||||.|...|:|.:||.||||.:||||
Mouse   924 PSNALVEEHLRDYARHNDIKRNATKTYHMKHTAEPEPRELFL 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNCAIP	NP_001295029.1	ANKYR	<369..556	CDD:440430	180/186 (97%)
		ANK repeat	396..429	CDD:293786	31/32 (97%)
		ANK repeat	431..501	CDD:293786	68/69 (99%)
		ANK repeat	503..534	CDD:293786	29/30 (97%)
		SNCAIP_SNCA_bd	559..602	CDD:435527	40/42 (95%)
Sncaip	NP_001186080.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..99		16/18 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	104..137		25/32 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	222..249		16/26 (62%)
		ANKYR	<321..508	CDD:440430	180/186 (97%)
		ANK repeat	348..381	CDD:293786	31/32 (97%)
		ANK 1	348..379		29/30 (97%)
		ANK repeat	383..453	CDD:293786	68/69 (99%)
		ANK 2	383..412		27/28 (96%)
		ANK 3	418..447		28/28 (100%)
		ANK repeat	455..486	CDD:293786	29/30 (97%)
		ANK 4	455..484		27/28 (96%)
		SNCAIP_SNCA_bd	511..554	CDD:435527	40/42 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	548..590		32/41 (78%)
		ANK 5	602..631		25/28 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	667..852		158/188 (84%)