Protein Alignment KLK4 and zetaTry

DIOPT Version :10

• Sequence 1: NP_004908.4
• Gene: KLK4 / 9622
• HGNCID: 6365
• Length: 254
• Species: Homo sapiens
• Sequence 2: NP_523691.1
• Gene: zetaTry / 36216
• FlyBaseID: FBgn0011556
• Length: 280
• Species: Drosophila melanogaster
• Alignment Length: 287
• Identity: 80/287 - (27%)
• Similarity: 121/287 - (42%)
• Gaps: 65/287 - (22%)

Human    10 WFLGYLILGVA---------------------GSLVSGSCSQIINGEDCSPHSQPWQAAL----- 48
            |.:|.|...|:                     |.:|.|..:.|.        ..|:|.:|
  Fly     5 WIVGLLAFLVSLVALTQGLPLLEDLDEKSVPDGRIVGGYATDIA--------QVPYQISLRYKGI 61

Human    49 -VMENEL--FCSGVLVHPQWVLSAAHC----FQNSYTIGLGLHSLEADQEPGSQMVEASLS--VR 104
             ..||..  .|.|.:.:...:::||||    ..:.|.:..|     .:.:.||..|..::.  |.
  Fly    62 TTPENPFRHRCGGSIFNETTIVTAAHCVIGTVASQYKVVAG-----TNFQTGSDGVITNVKEIVM 121

Human   105 HP-EYNRPLLANDLMLIKLDESVSESD-TIRSISIASQCPTAGNSCLVSGWGLLA-NGRMPTVLQ 166
            |. .|:.....||:.::.:|..:..:: ||::|.:|.:.|..|....|||||..: .|.....|.
  Fly   122 HEGYYSGAAYNNDIAILFVDPPLPLNNFTIKAIKLALEQPIEGTVSKVSGWGTTSPGGYSSNQLL 186

Human   167 CVNVSVVSEEVCSKLY----DPLYH--PSMFCAG----GGQDQKDSCNGDSGGPLICNGYLQGLV 221
            .|:|.:||.|:|.:.|    |..|.  .:|.|||    ||   .|:|.|||||||.....|.|:|
  Fly   187 AVDVPIVSNELCDQDYEDFGDETYRITSAMLCAGKRGVGG---ADACQGDSGGPLAVRDELYGVV 248

Human   222 SFGKAPCGQVGVPGVYTNLCKFTEWIE 248
            |:|.: |.....||||.|:.....||:
  Fly   249 SWGNS-CALPNYPGVYANVAYLRPWID 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLK4	NP_004908.4	Tryp_SPc	31..250	CDD:238113	73/245 (30%)
zetaTry	NP_523691.1	Tryp_SPc	38..273	CDD:214473	73/251 (29%)