DRSC/TRiP Functional Genomics Resources

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Protein Alignment CELSR1 and fmi-1

DIOPT Version :9

Sequence 1:NP_001365257.1 Gene:CELSR1 / 9620 HGNCID:1850 Length:3019 Species:Homo sapiens
Sequence 2:NP_506256.3 Gene:fmi-1 / 179788 WormBaseID:WBGene00001475 Length:2596 Species:Caenorhabditis elegans


Alignment Length:2899 Identity:779/2899 - (26%)
Similarity:1239/2899 - (42%) Gaps:544/2899 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   156 CRCP--------PRPRPRC--PGRPI-----------CLPPG-----GSVRLRLL---------- 184
            |..|        |..||.|  ||:||           |..||     .|.::.||          
 Worm    42 CAVPSSNSVIWLPASRPPCLHPGQPIIHWPDLSDNLACPVPGLPDSVHSSQISLLEGEGLLLTKE 106

Human   185 ----------------CALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRA 233
                            |..:.....:|:|.::.:                ...|...|.  .|.|
 Worm   107 RICFFDGPIDFHYDYVCDGKLYRSKMRIGHSIAS----------------KKKLETRRT--KRWA 153

Human   234 RRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRI 298
            ||......::.|....|...|.|:.|..|:|..:.|.:   ...:.:.|.|....|.||:..|.:
 Worm   154 RRRNPDANAVHFQQEKYVKELPEDTPIETIIASVKASH---ASSQPLYYSMVAPQDSRSQNLFTL 215

Human   299 DSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
            |:.:|.:.....:|||..:.|:|:|.|.:...|..||:|.:.|.|.|..|:||:||:..|...:|
 Worm   216 DTMSGEIRLAKSMDREVLDKHILKVTAYERVDPTISASTTVVVHVLDVQDNSPIFEKDSYFGEIR 280

Human   364 ENLEVGYEVLTIRASDRDSPINANLRYRV-LGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLV 427
            |:..:|..||::.|.|.||..|..:.|.: .|...::..:|..|||:.|.|.||||..:..:|.|
 Worm   281 EDAPIGTTVLSVFARDLDSGENGEIEYSLGEGNGKNLLAINAKSGVIQTAAPLDRETLSLIRLDV 345

Human   428 EANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNA 492
            .|:|:| .| ...:||.|.|.|.|.|||.|.|:..:|.|.:.|::.:...:..|:|||.|.|.|.
 Worm   346 IASDKG-TP-KRESTAMVEITVVDVNDNAPVFASDSYNVTILENITIPAVIATVKATDEDFGTNG 408

Human   493 AIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLD 557
            .:|||:.|.:..|...:...:|.:.:...:|.:: ...:..|:|:||.:|.| :|:..:::.|:|
 Worm   409 KVHYSMASSSGIGGLTIDYSTGEVTLRERIDAKN-SPITAVIRAKDGAQPAL-SSTVPLTINVID 471

Human   558 VNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNP 622
            :||:.|..:::....|:.|||.:|..|..:.|:|.|||.|..:.|.:..:..             
 Worm   472 INDHAPTLIAAQKMITLEENVAIGEEVGRVYAIDEDSGPNGIIKYSMEGSED------------- 523

Human   623 APTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVF 687
                   |.|...||.|.....||||....||..|.|.|.|:|.:::||::::.:.|:|||.|.|
 Worm   524 -------FIIDEDSGLIKTTKLLDRETTARYSLKVTARDMGTPSLNTSTTIAVVLKDINDNAPTF 581

Human   688 TQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDY 752
            .:..|.:.::|:...||.::||:|.|.|.:..|||::...:......|.....|.:::::..|. 
 Worm   582 DKKEYNVTISEEMPRGSQIITLKAVDNDEDQKITYRIEEADREVFSILDIGDQGAILSVSGELK- 645

Human   753 KQEQQYVLAVTASD-GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDE 816
            :|:.:..:.::|:| |.......|.:.:.|.|: .|.|....::|.:.|..|:|..:.||.|.|.
 Worm   646 RQDHKVRVEISATDQGGLQGRCVVNVFIDDVNS-APYFNDHPFSVKIPEHSPIGYPVITLKAEDH 709

Human   817 DTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEIL 881
            |.|:||||.|.| |....|||||.||.:....:||.|::..:::.:.|.|:..|..:.:|.:|::
 Worm   710 DRGDNARIVYSI-DSSQFFRIDPSSGDISVSSDLDREDRATFSVIVTASDHASPPLNTSTQIEVI 773

Human   882 ILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGD--FYIE 944
            :.|.|||:|||....|..:|.||.|..||.|||||.|.|.||||.:.|...........  |.::
 Worm   774 LDDINDNSPQFTSSSYAATISEDIPVGTSFLQVSAIDADIGPNGIVDYFLNESSSSPSIQLFRLD 838

Human   945 PTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVE 1009
            .|||.:|...:||||..||..|...|.|||:|: |||:.||.:|:.|:|||||.||:...:|::.
 Worm   839 RTSGTLRVSSKLDREQFAVIVLPIFARDRGTPS-LSAASEITLTLSDVNDNAPTFEQLSYDLYIA 902

Human  1010 ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLD---LLNGDLRAM--VELDFEVR-R 1068
            ||:||||.|..|.|.|.|||.||.|.::|..|.....|.::   ..||.:|.:  .|.|:|.: .
 Worm   903 ENSPVGSTVGTIVARDADEGDNADISFRIFGGADAKLFDIEEDAEQNGVVRILTRAEFDYEAKAN 967

Human  1069 EYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPD 1133
            ::...:||:|..|.|...|.|.:.|.|||.|.|.||.||.|.:    .|......||.|||.|||
 Worm   968 KFFFELQASSGQLSSTVPVRIHVSDVNDNKPALKDFVILMNRF----DNVQMARQIGFIPAFDPD 1028

Human  1134 VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTII 1198
            .:.:|.| |::.|:  |:..:..||::.:.::...|  ::...:..||||.::..:.|.....::
 Worm  1029 QNATLEY-FLEEND--LIEAEKYTGKILVKQEWKRN--MDVSFKTCVSDGANTECSTCRFIHVLV 1088

Human  1199 TDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTK-DDVFVFNVQNDTDVSSNILNVTF 1262
            ..:.|:.|.|:.|..|:.:.|..||:........:.||..| .|:.|..|:...|   :::.:..
 Worm  1089 EPEWLSESFTLSLARMTVDDFWDPLVFQRFRDAMSTLSNWKPSDIHVIGVKQHLD---DVIYINI 1150

Human  1263 SALLPGGVRGQFFPSEDLQEQI-YLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVSVLRFDS 1326
            :....|.|...:...|.::|.| .|.:..|..:...|     |..|..|||.:..||....:|..
 Worm  1151 AITDHGRVVRGWRAIELVKESIKKLEKMTLLQVEVIR-----DESCANEPCSHMAKCRQTQKFVG 1210

Human  1327 SAPFLSSTTVLFRPIHPINGLRCRCPPGFT-----GDYCETEIDLCYSDPCGANGRCRSREGGYT 1386
            ......:...:.|.::.:|...|.||.|||     || |:|.||.||...|..|..|.:.|..|.
 Worm  1211 EMKAHETDNFIARTLNTVNTFVCECPSGFTSSGAHGD-CDTRIDECYRGRCSNNSTCVAFENTYQ 1274

Human  1387 CECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEY------ERPYCEVTTR 1445
            |||...:.|.|||:...:..|..|.|.:...|.   :.|....|...:|      ||  |.:.:.
 Worm  1275 CECKPGWIGRHCEISVHALTCVPGYCMSDSLCE---LDGNQMKCRHCKYHGEDTDER--CRLRSV 1334

Human  1446 SFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAG-- 1508
            ||..:..:.......|..:|:....:|...||:|::.|  :::.||:.:.:||..:::.||.|  
 Worm  1335 SFDGEGLLNVNLDLPRTQWTMKFRVSTIAHNGVLVFTG--DKRSDFVEVSVVDRVLKVQFSLGGE 1397

Human  1509 ETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKD 1573
            :....:...|.:.::||.||:|.::|.|                |...:::|||:|..::.... 
 Worm  1398 KIDAKMENDVENRINDGEWHTVALEYSN----------------KQITMSLDDCETNPSLLLNT- 1445

Human  1574 IGNYSCAAQGTQTGSKKS----------LDLTGPLLLGGVPNLPEDFPVHNRQFVGCMRNLSVDG 1628
              :.:||.:......||.          ||::..|.|||.|...:..   .:.|.||:.:||||.
 Worm  1446 --SPNCAIRAKLNLEKKCEDPTVPCYRYLDISNGLFLGGRPGTSKQI---EKAFSGCISDLSVDK 1505

Human  1629 KNVDMA--------GFIANNGTREGCAARRNFC---DGRRCQNGGTCVNRWNMYLCECPLR---- 1678
            ::||.:        |.:     .|||..|::||   || :|.....|||||...:|.||..    
 Worm  1506 EDVDFSTIKEMHKVGQV-----HEGCKHRKDFCSTSDG-QCSATSKCVNRWGGRICSCPQSVHST 1564

Human  1679 ---FGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVL--MEATSGGPTS 1738
               .|....:....| .||..||.|.:....  :|||:.:...|||.:.|..:  :|.|... ..
 Worm  1565 GECVGALGTQDLRGH-SLFEEESFVLYQPSQ--VSVPFEVSFEFRTSRADMQVFALEFTQRS-VH 1625

Human  1739 FRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMD 1803
            :.|::.:..|::.:  |.|:||   |....||...|.:::|:.       |...:.|........
 Worm  1626 YNLEVDDGTLKYNI--GDSEVE---LPAPEVTSKHWMNVVIKF-------EADSVATSINGIYSA 1678

Human  1804 QNKADIG---------GMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMN 1859
            :.||.|.         |:.||       .|..|.        |.||::.|.:.|...:|..    
 Worm  1679 EAKASISDMNLESLYFGIAPG-------TGHPSR--------FEGCIRNVLVDGRSISVKK---- 1724

Human  1860 NALKVRVKDGCDVDDPCT-SSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHL-NPCENMGAC 1922
               |.:.:.||.|.:.|: .|.||..|.||.||..:.|.|.|.::|..|:..|.: |.|.: |.|
 Worm  1725 ---KGKTRAGCVVPNRCSVDSICPAESTCHRAWNKHKCKCHKSFVGDTCLPVCSVANVCSS-GTC 1785

Human  1923 VRSPGSPQGYVCECGPSHYGPYCENKLDLP---CPRGWWGN-PVCGPCHCAVSKGFDPDCNKTNG 1983
            | |..:..||.|.|.....|..|:  |:.|   ||.||||. |.|..|.||.:|.::..|:|..|
 Worm  1786 V-SSNTTAGYECICPAGKTGKNCQ--LEAPKQMCPSGWWGTFPRCRRCSCAQTKDYEAQCDKKTG 1847

Human  1984 QCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGVIGRQCNRC---DNPFAEVTT 2045
            .||||::::..:  :.|:.|:| ..|:.|..|. |.|.|.|....:||:|:||   |:.. :..|
 Worm  1848 ACQCKKSHFSTI--NGCVKCEC-GFGADSTECS-ADGHCKCNGDAVGRRCDRCSRFDHQL-DSKT 1907

Human  2046 LGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCSGEKGWLPPELFNCTTISFV 2110
            |.|..:...||...|..|.||.::.|......||.|..|.|.|.|.....|.....:|||...: 
 Worm  1908 LKCRPVSGKCPSEIEYSIQWPASQKGSIVRQSCPVGESGLATRKCLETGRWSDVNAWNCTRPEY- 1971

Human  2111 DLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDL 2175
                   .:..|:.::  ....:|:..:.:||....::.|.:.:.|.:.|..::.:|........
 Worm  1972 -------SIMVNKFEI--LEPSKLLTMVANATNTESSIRGRNQQIAAEALSRLVDYEQSMPMKGR 2027

Human  2176 AATQDADFHEDVIHSGSALLA--PATRAAWEQIQRSEGGTAQLLRRLEGYFSNVA---RNVRRTY 2235
            |..:|..|.|.:|.|...:::  ||          .|..|  |:.:|..|...||   .||  .:
 Worm  2028 AHIKDMKFTEKLIESLGRVMSEQPA----------DEYST--LISKLWNYAETVAEIHENV--NF 2078

Human  2236 LRPFVIVTANMILAVDIFDKFNFTGARVPRFDTIHEEFPRELESSVSFPADFFRPPEEKEGPLLR 2300
            |.||.:...:::.|   .||.:| |..:|:|:...:                           ||
 Worm  2079 LSPFFVANDHIVFA---SDKLDF-GNILPKFNNFVD---------------------------LR 2112

Human  2301 PAGRRTTPQTTRPGPGTEREAPISRRRRHPDDAGQFAVALVIIYRTLGQLLPERYDPDRRSLRLP 2365
            |.|   .|:......||.:                      ::|    .::|           .|
 Worm  2113 PTG---FPRVRAIVTGTTQ----------------------VVY----SIVP-----------YP 2137

Human  2366 HRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARG 2430
            .......||::.:..:..         ||:|||.:.|.:....|.||.::..     :|.|:|||
 Worm  2138 RCNRCENPMIAIVANTSD---------PVIVEFEIEEDDGWKYPECVRFDEK-----SGTWTARG 2188

Human  2431 CELLSRNRTHVACQCSHTASFAVLMD--------ISRREN-------GEVLPL----KIVTYAAV 2476
            ..|:..|.||.||:.:....|.:.::        :::.:|       |..|.|    .::|.:..
 Worm  2189 AALIGLNLTHAACEYNRIGVFTMFVNDQSSSIVRVAQMDNMTSPAIAGVALFLCFLSILLTLSRR 2253

Human  2477 SLSLAALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLSQLVFVIGINQTENPFLCTVVAILLHYI 2541
            ||...::.:.|:|...:.:|  ||..:||              ..|||.    .|.|...:|.:.
 Worm  2254 SLKTHSVRIGFILFFAINIL--NLFFVHK--------------TAINQA----YCPVRNAMLSFT 2298

Human  2542 YMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWGIPAIVTGLAVG------LDPQGYGNP 2600
            ..:.|||..:..|::||||.:               |...|::.|.|.||      :....:...
 Worm  2299 SSAPFAWLFLYGLYIYRMLAD---------------GSSSPSLTTSLLVGIVFPCLISFTTFFVT 2348

Human  2601 DFCWLSLQDTLIWSFAGPIGAVIIINTVTSVLSAKVSCQRKHH-YYGKKGIVSLLRTAFLLLLLI 2664
            |.|.||....|.|....|||..::::...:..|..||..:|:. :..|..:...:...|:|.:..
 Worm  2349 DQCSLSPHLWLFWCIILPIGLFLLLSFYAAATSVLVSLHKKYDVFVAKYNVKRAVFQHFILTIFT 2413

Human  2665 SATWLLGLLA--------VNRDALSFHYLFAIFSGLQGPFVLLFHCVLNQEVRKHLKGVLGGRKL 2721
            ....|.||.|        :...:.|..||.|       ..|:...||.:                
 Worm  2414 LGMTLTGLFANQLPLPMEIMEISQSIIYLIA-------ALVIFLWCVCD---------------- 2455

Human  2722 HLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEGIQKLGVSSGLVRGSHG 2786
                 .||:|:            ...|.|.          ||:       ||    |.:...:..
 Worm  2456 -----ITTKAS------------DSNPSMW----------LDN-------QK----SVMAESTMA 2482

Human  2787 EPDAS---LMPRSCKDPPGHDSDSDSELSLDEQSSSYASSHSSDSEDDGVGAEEKWDPARGAVHS 2848
            :|..:   |.||.    ..|:...|||...|...|::  .|:|.:|.|        .|.|..:  
 Worm  2483 DPQCASPLLSPRH----QHHEVPMDSEWVPDVNPSNH--YHTSINEPD--------TPRRLLL-- 2531

Human  2849 TPKGDAVANHVPAGWPDQSLAESDS----EDPSGKPRLK 2883
             |:...|.|.:.:  |||.|.|...    .:....|||:
 Worm  2532 -PQNRDVINILSS--PDQILNEGVGHVYRNNMGSLPRLR 2567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CELSR1NP_001365257.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..242 6/37 (16%)
Cadherin_repeat 250..349 CDD:206637 29/98 (30%)
Cadherin_repeat 357..455 CDD:206637 36/98 (37%)
Cadherin_repeat 464..561 CDD:206637 27/96 (28%)
Cadherin_repeat 569..683 CDD:206637 33/113 (29%)
Cadherin_repeat 691..785 CDD:206637 22/94 (23%)
Cadherin_repeat 793..888 CDD:206637 34/94 (36%)
Cadherin_repeat 897..995 CDD:206637 44/99 (44%)
Cadherin_repeat 1003..1097 CDD:206637 35/99 (35%)
Cadherin_repeat 1117..1198 CDD:206637 22/80 (28%)
EGF_CA 1364..1399 CDD:238011 14/34 (41%)
EGF_CA 1407..1441 CDD:238011 9/39 (23%)
LamG 1444..1627 CDD:238058 45/194 (23%)
EGF_CA 1651..1685 CDD:238011 14/43 (33%)
Laminin_G_2 1719..1849 CDD:396680 31/140 (22%)
EGF_CA 1874..1908 CDD:238011 13/34 (38%)
TNFRSF 1881..2011 CDD:419870 50/134 (37%)
EGF_Lam 2002..>2040 CDD:238012 15/40 (38%)
HormR 2052..2113 CDD:214468 18/60 (30%)
GAIN 2130..2381 CDD:406802 46/255 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2291..2328 7/36 (19%)
GPS 2407..2460 CDD:197639 15/60 (25%)
7tm_GPCRs 2465..2718 CDD:421689 59/271 (22%)
TM helix 1 2467..2492 CDD:410628 6/28 (21%)
TM helix 2 2501..2523 CDD:410628 2/21 (10%)
TM helix 3 2532..2559 CDD:410628 7/26 (27%)
TM helix 4 2571..2591 CDD:410628 4/19 (21%)
TM helix 5 2608..2637 CDD:410628 6/28 (21%)
TM helix 6 2649..2676 CDD:410628 6/34 (18%)
TM helix 7 2680..2705 CDD:410628 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2777..2939 28/114 (25%)
fmi-1NP_506256.3 Cadherin_repeat 170..266 CDD:206637 29/98 (30%)
Cadherin_repeat 274..371 CDD:206637 36/98 (37%)
Cadherin_repeat 379..475 CDD:206637 27/97 (28%)
Cadherin_repeat 486..577 CDD:206637 33/110 (30%)
Cadherin_repeat 686..780 CDD:206637 34/94 (36%)
Cadherin_repeat 788..888 CDD:206637 44/100 (44%)
Cadherin_repeat 896..996 CDD:206637 35/99 (35%)
EGF_CA 1252..1287 CDD:238011 14/34 (41%)
LamG 1333..1504 CDD:238058 45/194 (23%)
LamG 1582..1716 CDD:238058 38/163 (23%)
EGF_CA 1774..1808 CDD:238011 12/35 (34%)
EGF_Lam 1865..1911 CDD:238012 17/48 (35%)
HormR 1917..1974 CDD:214468 18/64 (28%)
GPS 2170..2218 CDD:197639 15/52 (29%)
7tm_GPCRs 2237..2455 CDD:421689 59/259 (23%)
TM helix 2 2258..2284 CDD:410628 7/41 (17%)
TM helix 3 2289..2315 CDD:410628 6/25 (24%)
TM helix 4 2326..2346 CDD:410628 4/19 (21%)
TM helix 5 2356..2383 CDD:410628 6/26 (23%)
TM helix 6 2400..2435 CDD:410628 6/34 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C161463591
Domainoid 1 1.000 94 1.000 Domainoid score I5169
eggNOG 1 0.900 - - E2759_KOG4289
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7665
Inparanoid 1 1.050 926 1.000 Inparanoid score I183
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48446
OrthoDB 1 1.010 - - D16905at33208
OrthoFinder 1 1.000 - - FOG0001609
OrthoInspector 1 1.000 - - otm15547
orthoMCL 1 0.900 - - OOG6_103211
Panther 1 1.100 - - LDO PTHR24026
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X912
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.810

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