|
Human 3 GSTQPVAQTWRATEP------RYPPHSLSYPVQIARTHTDVGLLEYQH--HSRDYASHLSPGSII 59
|..||..:. |.:|. ..||| |.| .|......:.|| |.:.: ...||..:.
Fly 542 GGQQPYKKQ-RLSEANANNMNHLPPH----PQQ---QHQQQQQQQQQHQAHQQQH-QRSSPAQVQ 597
Human 60 QPQRRRPS---------------------LLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFI 103
|.|:::.: |..|..|..::.|:.|.:.:... .:.|:|:
Fly 598 QQQQQQMNSSRQSHNDMCRQVVTTPMGMQLKVETLPQQQQKQQQHQQQQQQQ--QQQGRSQ---- 656
Human 104 ESKRPRLELLPDPLLRP------------------SPLLATGQPAGSEDLTKDRSLTGKLEPVSP 150
|.:..:...:.:| |..:|.|...|:.......:...::|.:||
Fly 657 ----PVVSSMSTVVSQPVGTVTVTTAGLSASHSGSSGNVAAGLGTGNTGSASTEAYHPQVEAISP 717
Human 151 PSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEA--AKPPEPEKP 213
..| :|..:|......:||:|:..:.:||.||...|..:..|:||::.|.||| ||.....|.
Fly 718 TLP--SDSSIEERGRTSAKEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKE 780
Human 214 VS------PPPIESKHRS--LVQIIYDENRKKAEAAHRILEGLGPQVE----------LPLYNQP 260
:: .|.:|...|| |.:.||..|||.|:|.|.:|:....... |||||||
Fly 781 LNDNNNDQEPMVELSWRSQMLAEKIYAANRKTAQAQHSMLQNAAADESSPGSVAGRPWLPLYNQP 845
Human 261 SDTRQYHENIKINQA-MRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRA 324
.|.......|:.:|: :|..|:|:.::....|....|...::|.:....|:::.||:|.:.:|:|
Fly 846 LDVEALAMLIRQHQSQIRAPLLLHIRKLKAERWAHNQGLVEKYTKDQADWQRRCERMEASAKRKA 910
Human 325 KESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQM 389
:|:|.||::||.|.|:|||||.:||. :|||.| .:||.::.||:|||.||...:|:|
Fly 911 REAKNREFFEKVFTELRKQREDKERF-NRVGSR--------IKSEADLEEIMDGLQEQALEDKKM 966
Human 390 RQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLI 454
|..|||||:::||.|:|..:.|.|||:.|.:.|::.|:.:|||:..|||||:||::|||||||.|
Fly 967 RSYAVIPPLMHDARQRRCAYHNENGLIEDMVAVHQQRKALNMWTAGEKETFKEKYLQHPKNFGAI 1031
Human 455 ASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQ---------------- 503
|:.|:||:..:||.||||:||.||||.|:|:|.:|...|:...:.|..|
Fly 1032 AASLDRKSPQDCVRYYYLSKKTENYKQLLRKSRQRTRSSRNPAKAQAAQPQCIIDSMTTGVMTRL 1096
Human 504 QQQQQQQPMPRSS---QEEKDEKEKEKE-------------AEKEEEKPE--------------- 537
|::|||:...||| :.|:.|:..|:| ||...||..
Fly 1097 QREQQQKSGGRSSAVAERERAERAAERERVAEKAAADAAKAAESAAEKASAATKAVEATAAGEKV 1161
Human 538 ---------------------------------------------------VENDKEDLLK---- 547
:..||.|..|
Fly 1162 AKAAAAAAAAAATTATTATTTTSSSTSSSSSSASSASTASSSTASPATLAGIAADKTDAGKTASA 1226
Human 548 -EKTDDTSG------------------------------EDNDEKEAVASKGRKTANSQGRRKGR 581
:|...|:| ..|.|:||.|:.|..|..:.|.....
Fly 1227 SDKNAATAGGPTATGTPTAATTPATATAPPEISAGGEAKSKNAEEEAAATAGAATVATAGTPATG 1291
Human 582 ITRSMANEANSEEAITPQQSA------ELASMELNESSRWTEEE-------METAKKGLLEHGRN 633
.:.:.|.||.:....|...:| |.|:.....:::..:.. .:||.|.:...|.|
Fly 1292 ASAASAGEATTATGATATAAAKGVGKPETATEPAGTAAKGADSRPDANDPLAKTASKAINAEGYN 1356
Human 634 WSAIARMVGSKTVSQCKN-----------------------FYFNYKKRQNLDE----------- 664
.:|..:.|...| ...|.|.....|:
Fly 1357 ------AIGGNSSSSSSNATGASAPVQGVTLNGFKPGYQTVVMANVKASTGGDDSGANAGGAAPG 1415
Human 665 -------ILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGV---------SGN 713
.:.....|:.|...:.| ||.:.|..|| :|....:|| :||
Fly 1416 SLAATNASIATSGDKIVKTTPSSR----APNSTSSTAA------NESSSGAGVNTYGHTATTAGN 1470
Human 714 ---------EEEMVEEAEALHASGNEVPR-------GECSGPAT--VNNSSDTESIPSPHTEAAK 760
:.|.:.....||:..:|..| ||..|.|| :.|||.:.|:...::...|
Fly 1471 YLGQKLKAAQVEGLGAGNELHSDVSESKRKRFELNSGEAGGNATSAMTNSSTSGSMNISNSHGLK 1535
Human 761 DTGQNG-------------------PKPPAT---------------------------------- 772
...::| ..|.|:
Fly 1536 ANAKDGSMMAKTSMASTSSASVVVTSTPSASSSSLSSASSMLLISAASVMSTAAGATSSSTATTT 1600
Human 773 ---------LGADGP------------------------------PPGPPTP---------PPED 789
|.|||. |...|.. |.|.
Fly 1601 ATASAISLPLLADGSGNSMVNANEILALDGKDKLASCFVCKAEACPRTRPLKKGRGQQYGIPDET 1665
Human 790 IPAPTEPTPASEATGAPTPPPAPPSPSAPPPV--------VPKEEKEEETAAAPPVEE---GEEQ 843
|||......:.:.....:..|..|.|:.|.|. :|....| .||.|.: .|.|
Fly 1666 IPAGARVCNSCQCKSVRSRYPNCPLPTCPNPKDRAQRLRNIPSRLFE----LAPEVRDPLMAEFQ 1726
Human 844 KPPAA----------------EELAVDTGKA----------EEPVKSECTEEAEEGPAKGKDAEA 882
.||.| .:|.:..|.: |..|.:...:|.|.| |.|..:
Fly 1727 IPPHATRCCSACLMRIRRKLDPQLNLTDGSSGGAGSGSGGDETDVSTSSCDEREPG---GSDTAS 1788
Human 883 AEATAEGALKAEK---------------------------------------------------- 895
.|:... |:..|
Fly 1789 VESPEN--LQRHKSLTMVKQQQQQQQQQQQQQQQQQQQQQQQLSQPQPPPPAPQQQKGSSGRGGD 1851
Human 896 -------------KEGGSGRATTA---------------KSSGAPQDSDSSATCSADEVDE---- 928
.:.|||.|.|| |.....::.|||||.:|||.:|
Fly 1852 QGTPLIITPTRMSSKSGSGGAQTAGDNERLLPPAAGQAPKKQKTSEEYDSSATETADEENENSPA 1916
Human 929 --------------AEGGDKNRLLSPRP---SLLTPTGDPRANASPQK---PLDLKQLKQRAAAI 973
..||..|.:...:| ::.|..|.....|:.|: |:.: |..|:
Fly 1917 NRQSPKVLFHGHGHGHGGHANNVAGLQPPVANMGTGGGVQPGGAAGQQVNGPISM-----RREAV 1976
Human 974 PPIQ--VTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQ----------PGSSPRGKSRSP 1026
..:| |..|.|...:...| ||:....|| .|.:| |:|:||
Fly 1977 NNVQDCVFSVIERSLKHKGP--------------QPKGGQGQQQGQGQGQGQGQGQTP-GQSQSP 2026
Human 1027 APPADKEAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSY---------APP-- 1080
:....::.....|..| ..:|:.....:..||..... |||
Fly 2027 SQQQQQQQQQQSANNL---------------ERKELTIVREYRQDPGILKQQQQQQQAGGAPPTS 2076
Human 1081 -GHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAP 1144
...||.| .:.:.:..||..::.||| .|| :.....|...........:.......:.
Fly 2077 AAGSLPHG--TSVQKLTTRPAAVAPPPP-----AHP-LTPTSTGCAGSNNGTSDSLATLSVVNSH 2133
Human 1145 VGPVTMGLPLPMDPKKLAPFSGVKQEQLSP--RGQAGPPESLGVPTAQEASVL-RGTALGSVPGG 1206
:|.|.:|.|.||.....|...||.:..::| :..:|..:|.|...:..::.. ..|.:.:||..
Fly 2134 MGMVGIGHPGPMAHASSAGGIGVDKATITPVVKSSSGSSKSGGGSASSHSTATPPETIIYNVPVA 2198
Human 1207 SITKGIPSTRVPSDSAI--TYRGSITHGTPADVLYKGTITRI-IGEDSPSRLDRGREDSLPKGHV 1268
...:|||. ||..:: .:.....|.........|..|:: :.|..|..||...:.....||.
Fly 2199 HPQRGIPP---PSQHSVHPAHPSHTQHPAHPQHSSHGQHTQLQVPEPEPQTLDLSIKKPPRDGHS 2260
Human 1269 IYEGKKGHVLSYEGGMSVTQCSKEDGRSSS----GPPHETAAPK---RTYDMMEGRVGRAISSA- 1325
.:.| .|.|.:..|...|.||| |||..|.:.| |:..|..|......|.|
Fly 2261 PHTG---------AGGSSSSGSGSGGPSSSDRHHGPPPPTMSMKHIVRSGGMYRGDTVTVPSLAA 2316
Human 1326 ---------SIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLR--------- 1372
|::.:.|..:.| .:..|:|.|.: ||:
Fly 2317 PSSYLYPTRSVKTIGGGGVVP----------------GVLPGVPGSAL-----YLQPVPVPVPIS 2360
Human 1373 --REAKLLKREGTPPP--PPPSRDLTEAYKTQALGPLKLKP--AHEGLVATVKEAGRSIHEIPRE 1431
.:.:|..|.|.||| ||..|.:.:. |.||.| ||....:......:...:..::
Fly 2361 ISGQGQLPPRAGQPPPAQPPSGRGVAKV-------PPKLSPQQAHHLHPSHGHSPSQQQQQQQQQ 2418
Human 1432 ELRHTPELPLAPRPL--KEGSITQGTPLKYDTGASTTGSK--KHDVRSLIGSPGRTFPPVHPLDV 1492
:.:...:...|.:.| |.||||.||| |::...: .|...:...:|.....|...
Fly 2419 QQQQQQQAAAAQQQLLVKSGSITHGTP------ANSAQQQIIVHAPATAAAAPSSLLSPKFD--- 2474
Human 1493 MADARALERACYEESLKS-RPGTASSSG--GSIARGAPVIVP----------------------- 1531
.|.|....|.:.| .||.||.|| |||.:|.|:.:|
Fly 2475 -----GLVRQTTPEGVGSVGPGGASGSGKHGSITQGTPLHMPPHHLESKRPYESYYKSSQRHSPA 2534
Human 1532 -------ELGKPRQ--SPLTYEDHG-----------APFAGHLPRGSPVTTRE------------ 1564
:|..|.| ||......| :||||.:.:...::||:
Fly 2535 QQPGGNQQLPPPPQQSSPQAPPPQGYGVGVSSPYARSPFAGVVEQPQVLSTRQIVMHDYITSQQM 2599
Human 1565 ------------------------------------PTPRLQEGSLS------------------ 1575
|:||...||.|
Fly 2600 QGQQQQQQQQQQQQRNMSRGSSASGGGGGGGSDKESPSPRNSVGSASGFAYGGDKESAPRGRPEY 2664
Human 1576 SSKASQDRKLTSTPREIAKSPHSTVP-------EHH------PHP---------ISPYEHLLRGV 1618
||:||....:.||| |||.|.| :.| |.| :.||:: ..
Fly 2665 SSRASPADHVNSTP-----SPHRTPPPQRQGVIQRHNTGSKPPSPAAPPPSRMHMPPYQY---AP 2721
Human 1619 SGVDLYRSHIPLAFDPTSIPRGIPLD--------AAAAYYLPRH---LAPNPTYPHLY------- 1665
||.|...|.:.:|.....:| :|.. :.|...:|.. |.|:|..||..
Fly 2722 SGHDALASFVDVAVQQPQLP--VPSQKDDKSPGPSTAPGQVPGSGPPLGPSPLPPHAVVGVAQPP 2784
Human 1666 PP--YLIRGYPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGP 1728
|| :..:.|.|.....:..|::...| :||.|:.:....|| .||.|.:...:..:........
Fly 2785 PPTAHHDQRYRDLTLHHHHHTLVQQQI-AQQQHYRSLNVAAQ-VDMQRQMDQAKRVMRHQQHQVQ 2847
Human 1729 RGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSS 1793
:......|..| ..|...|| ...:....|... :......
Fly 2848 QQQQQQQQQQH----------NHALERDR-----EMQERMRERDRE------------RERERER 2885
Human 1794 SERERDRDRERDRDREREKSILTSTTTV-----EH-----APIWRPGTEQSSGSSGGGGGSSSRP 1848
.:|||:|:|||:|:||||:........| || ..::.......||.:||||.|..:
Fly 2886 EQRERERERERERERERERREQDRARRVVAEEREHDSRRMERMFAGNVVTGSGGAGGGGPSPGQ- 2949
Human 1849 ASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPST--PTVLRSTSTSSPVRPAATFP 1911
.:.|..|.| |..:......|..|.|...|
Fly 2950 ----------------------------------FLRASVPETGPPRSIPDRERESYYRQAHGGP 2980
Human 1912 PATHCPLGGTLDGVYPTLMEPVL---LPKEAPRVARPER--PRADTGHAFLAKPPARS----GLE 1967
.....| |.|.. .:|::.:: :.:.....|.|.| ||....||.| ||..| |..
Fly 2981 APEDTP--GQLSA--QSLIDAIIKHEINRSNDATAGPGREFPRPSFVHAPL--PPRGSGSGGGTG 3039
Human 1968 PASSPSKGSEP---RPLVPPVSGHATIARTPAKNLAPHHASPDPPA-----------PPASASDP 2018
..|||:....| |.|..|:.|.|....|...|..| :|...|: ..|:|:..
Fly 3040 TRSSPANVLHPMYLRDLRQPLDGGAGSMLTAENNGKP--SSSGSPSVINIDLDQERISAAAAAVA 3102
Human 2019 HREKTQSKPFSIQELELRSLGYHGSSYSPE----GVEPVSPVSSPSLTHDKGLPKHLEELDKSHL 2079
.:::.|..|...|..:.||: ||...:|. |..| ||...|.|.:. ..||..|.:
Fly 3103 QQQQQQQAPPPSQSSQSRSV--HGQLRTPTSQAGGSAP-----SPQQIHTKSIT--FGELTDSII 3158
Human 2080 EGELRPKQPGPVKLGGEAAHLPHLRP-----LPESQPSSSP--------LLQTAPGVKGH----Q 2127
..:.... ||||| |.|:|....| :.|.|...|.| |
Fly 3159 TSDYGTN--------------PHLRPPYMAYLQETQSILPPDRWKQNRRMQQKAEEAKHHSQQQQ 3209
Human 2128 RVVTLAQHISEVITQDYTRHHPQQLSAPLPAP-LYSFPG--------------------ASCPVL 2171
:.....||.::...|...:||.||....:|.. ..|.|| ||.|..
Fly 3210 QQQHQQQHHAQQQQQQQQQHHAQQHHPQMPGTGSGSAPGGAGQGGGSGGPGSGGGGAGRASTPGE 3274
Human 2172 D----LRRP--------------------------------PSDLYLPPP------DHGAPARGS 2194
| :|.| ||.:.||.. ..|||..|.
Fly 3275 DGRNIIRMPQAVSPRKFNHEMMLHHVMGTTGAGGEAGQFFLPSRVVLPEQRGTPSGGGGAPGAGG 3339
Human 2195 PHSEGGKRSPEPN-KTSV-------LGGGEDGIEPVSPPEGMTEP--GHSRSAVY---------- 2239
|.|.||..:.|.. ||.: :|.|::....|...:.:|.. .||.:||:
Fly 3340 PGSGGGATTIEKYVKTRIAEVMRDDIGYGKNRTVEVRTEDEVTADMVAHSHAAVHAAHVAHAAHV 3404
Human 2240 ------PLLYRDGEQTEPS-RMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRN 2297
.|.:|..|...|. .:..|:|.......|...:...|.|..| .::...:.|:..
Fly 3405 AHAAAMELQHRSKEPPPPEISVSRKTPNQYEVVDASGRRSAGSGSVSV-----SVSGANSHHSPY 3464
Human 2298 EPEYNISQPGTEIF-----NMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKALMGKYDQWEES 2357
.|......|.|..| |:|...| .:..|....:..:|: :
Fly 3465 HPPAAAYAPSTYAFPYSALNVPGAAG---------GLPPHQPLQLAHQAV--------------A 3506
Human 2358 PPLSANAFNPLNASASLPAAMPITAADGRSDHTLTSPG--GGGKAKVSGRPSSRKAKSPAPGLAS 2420
|| .|| |..::.|.|:..| |||.:.|.|..|. |:|.
Fly 3507 PP---GAF-----------------AKAKAAHALSELGAVGGGVSLVVGGGSG--------GIAG 3543
Human 2421 GDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGS 2485
| |..|| .|| |:|.|.
Fly 3544 G--PGGVS-----------------------------------------VGV-------GVPGGG 3558
Human 2486 GPLA-----GPHH---------------AWDEEPKPLLCSQYETLSDSE 2514
||.: |.|: |...|.||||.|:|:.|||.:
Fly 3559 GPGSGGGGGGGHNSSSSQASAAVAAAVAAAASESKPLLLSKYDALSDED 3607
| 
