DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCOR1 and CoRest

DIOPT Version :9

Sequence 1:	XP_005256923.1	Gene:	NCOR1 / 9611	HGNCID:	7672	Length:	2524	Species:	Homo sapiens
Sequence 2:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster

Alignment Length:	791	Identity:	150/791 - (18%)
Similarity:	252/791 - (31%)	Gaps:	284/791 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   335 ENNPRRKAK-ESKTREYYEKQFPEIRKQR-----------EQQERFQRVGQRGAGL-SATIARSE 386
            :|:.:|..| ::|..||.||    ||..|           |.:.|.:::.:|...: |.|....:
  Fly    72 DNSTKRNGKSKAKQSEYEEK----IRVGRDYQAVCPPLVPEAERRPEQMNERALLVWSPTKEIPD 132

Human   387 HEISEIIDGLSEQ--ENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVW 449
            .::.|.|....|:  .|.|:.:..|                |.:.:.|....|.:.....|.:.|
  Fly   133 LKLEEYISVAKEKYGYNGEQALGML----------------FWHKHDLERAVMDLANFTPFPDEW 181

Human   450 TDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQQ 514
            |..:|.:|:..|..|.|:|..|...|..||:...|.|||..||..:..:.:.|
  Fly   182 TIEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDR------------ 234

Human   515 IARPSQEEKVEEKEEDKAEKTEK--KEEEKKDEEEKDEKEDSKENTKEKDKIDGTAEET------ 571
                 ||:.::...:|.:|...:  ..||..::::|....:|..||     ||.|...|
  Fly   235 -----QEKAIKAVVKDGSENGSEVGSNEESDNDDKKGHGTNSTINT-----IDATTTSTNNSTTN 289

Human   572 ---------------------------------EEREQA-------------------------- 577
                                             ||..||
  Fly   290 SNTTTPANIIANTINSNHSSSNSGGGGNINNNGEENIQAVGGSNTISNTSNNDMDAEQLSLFAGN 354

Human   578 ----------------------------------------------------------TPRGR-- 582
                                                                      :|.||
  Fly   355 AQIEEMMALGLAADRAIGANGGNNNNNGEMGGDPGLMRRMVVGGFCKICNVVCHVLHDSPLGRMC 419

Human   583 KTANSQGRR----------KGRITRSMTNEAAAASAAAAAATEEPP------------------P 619
            |:.::..||          :|...|..|:..|   |.|..:..:||                  |
  Fly   420 KSCHTHWRRTGNRRPISGPEGNAPRRSTHNCA---ATADRSKRKPPKGMYINHDDLTALASCGNP 481

Human   620 PL-----------------------------------------PPPPEPISTEPVETSRWTEEEM 643
            .|                                         |......|.:|..::||..:|:
  Fly   482 SLYLAERERKLTALMAEIQKNRQVMEQLDKECETINVDDVLSKPAAANTESAQPRISARWLPDEI 546

Human   644 EVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHK----QKTSRKPREER 704
            :||...:.|:|:|:..|||:|.||:||..:.||.|.:||:|||.::::::    :::..:.:.|.
  Fly   547 QVALLAIREYGKNFPTIAKVVATKTEAHVRTFYLNNRRRYNLDQIVKEYEAGKSEESGAEEQTEP 611

Human   705 DVSQCESVASTVSAQE--DEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAVKP-------- 759
            .|....:.|:|.||..  |....||...:..:.:|.:.|..:|.....|...:..||
  Fly   612 AVDAAAAGAATASAPSAADSTSAASATADRKQSTENSNNGVETMQESLPKKEDPKKPELAAAVLK 676

Human   760 ---SEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQ 821
               :|.:...||...:|...|....|:.:.||||.::.:.........|....|...::..|..
  Fly   677 IGVAEAADAVATVASSTASGVIGAATSASKPSTSATITIIDESDTATNSSSDVVTTGLATSTGS- 740

Human   822 MDVDQQEHSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDED- 885
                    ||...:...|...|:..|.::..: ..|.||.:............|:.....||..
  Fly   741 --------SALSSTTSAPASKTQTSSEELSAQ-KSNPASGIAAIGAATGGGQTANSSGSKRDSSV 796

Human   886 LVVAQQINAQR 896
            |.||:|..|::
  Fly   797 LPVAEQPPAKK 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCOR1	XP_005256923.1	GPS2_interact	149..238	CDD:406267
		SANT	449..491	CDD:238096	16/41 (39%)
		Myb_DNA-binding	637..680	CDD:395191	19/42 (45%)
		MSCRAMM_ClfB	<733..929	CDD:411414	35/176 (20%)
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	10/51 (20%)
		SANT	179..225	CDD:197842	17/45 (38%)
		SANT	180..224	CDD:304392	16/43 (37%)
		SANT	540..582	CDD:238096	18/41 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000