|
Human 12 AFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFH 76
|.:...:..||| |..:|||:........:|.:..|.|...|.|||||.:...|..|.
Fly 555 ANANNMNHLPPH------PQQQHQQQQQQQQQHQAHQQQHQRSSPAQVQQQQQQQMNSSRQSH-- 611
Human 77 PGSDRPQERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQR-------------VSAAVLP 128
:|..::..| :|:.........|:.:|....|.|: ||:....
Fly 612 --NDMCRQVVT---------TPMGMQLKVETLPQQQQKQQQHQQQQQQQQQQGRSQPVVSSMSTV 665
Human 129 LVHPL------PEGLRASADAKKDPAFGGKHEAPSSPI-SGQPCGDDQNAS-------------- 172
:..|: ..||.|| |...|..: :|...|:..:||
Fly 666 VSQPVGTVTVTTAGLSAS------------HSGSSGNVAAGLGTGNTGSASTEAYHPQVEAISPT 718
Human 173 -PSKLS---------KEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEA--AKPPEPEKPVS- 224
||..| ||:|:..:.:||.||...|..:..|:||::.|.||| ||.....|.::
Fly 719 LPSDSSIEERGRTSAKEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKELND 783
Human 225 -----PPPVEQKHRS--IVQIIYDENRKKAEEAHKIFE----------GLGPKVELPLYNQPSDT 272
.|.||...|| :.:.||..|||.|:..|.:.: .:..:..|||||||.|.
Fly 784 NNNDQEPMVELSWRSQMLAEKIYAANRKTAQAQHSMLQNAAADESSPGSVAGRPWLPLYNQPLDV 848
Human 273 KVYHENIKTGVPARRMMKNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENN 337
:.....| |..::|: |..|:|..::....|....|.:.::|.:....|:::.:|:|.:
Fly 849 EALAMLI-------RQHQSQI-RAPLLLHIRKLKAERWAHNQGLVEKYTKDQADWQRRCERMEAS 905
Human 338 PRRKAKESKTREYYEKQFPEIRKQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENN 402
.:|||:|:|.||::||.|.|:|||||.:|||.|||.| .:||.::.||:|||.||...
Fly 906 AKRKAREAKNREFFEKVFTELRKQREDKERFNRVGSR--------IKSEADLEEIMDGLQEQALE 962
Human 403 EKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKN 467
:|:||..:||||:|.||.|||..:.|.|||:||.:.|::.|:.:|:||..|||.||:|::|||||
Fly 963 DKKMRSYAVIPPLMHDARQRRCAYHNENGLIEDMVAVHQQRKALNMWTAGEKETFKEKYLQHPKN 1027
Human 468 FGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQQIARPSQEEKVEEKEEDKA 532
||.||:.|:|||..|||.||||:||.||||.|:|::..:.|.......|:.:|.:.:.:......
Fly 1028 FGAIAASLDRKSPQDCVRYYYLSKKTENYKQLLRKSRQRTRSSRNPAKAQAAQPQCIIDSMTTGV 1092
Human 533 EKTEKKEEEKKD--------EEEKDEKEDSKENTKEKDKIDG--TAEETEERE-------QATPR 580
....::|:::|. |.|:.|:...:|...||...|. .||...|:. :||..
Fly 1093 MTRLQREQQQKSGGRSSAVAERERAERAAERERVAEKAAADAAKAAESAAEKASAATKAVEATAA 1157
Human 581 GRK--------------TANSQGRRKGRITRSMTNEAAAASAAAAA------------------- 612
|.| ||.:........|.|.::.|::||.|:::
Fly 1158 GEKVAKAAAAAAAAAATTATTATTTTSSSTSSSSSSASSASTASSSTASPATLAGIAADKTDAGK 1222
Human 613 ----------------ATEEP-----PPPLPPPPEPISTEPVETSRWTEEE-------MEVAKKG 649
||..| |.....||| ||......|:..||| ..||..|
Fly 1223 TASASDKNAATAGGPTATGTPTAATTPATATAPPE-ISAGGEAKSKNAEEEAAATAGAATVATAG 1286
Human 650 LVEHGRNWAAIAK---MVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCES 711
....|.:.|:..: ..|..:.|..|.. .|.:|:.:|
Fly 1287 TPATGASAASAGEATTATGATATAAAKGV----------------GKPETATEP----------- 1324
Human 712 VASTVSAQEDEDIEA-------SNEEENPE--DSEGAENSSDTESAPSPS-PVEAV-----KP-- 759
|.|.:...|...:| :::..|.| ::.|..:||.:.:|...| ||:.| ||
Fly 1325 -AGTAAKGADSRPDANDPLAKTASKAINAEGYNAIGGNSSSSSSNATGASAPVQGVTLNGFKPGY 1388
Human 760 -------------SEDSPENATSRGNTEPAVELEPTTETAPS------TSPSLAVP---STKPAE 802
.:||..|| |...|..........|.| |:||...| |:..|.
Fly 1389 QTVVMANVKASTGGDDSGANA---GGAAPGSLAATNASIATSGDKIVKTTPSSRAPNSTSSTAAN 1450
Human 803 DESVETQVN----------------------DSISAETAEQMDVDQQE------HSAEEGSVCDP 839
:.|....|| :.:.|......||.:.: :|.|.|.
Fly 1451 ESSSGAGVNTYGHTATTAGNYLGQKLKAAQVEGLGAGNELHSDVSESKRKRFELNSGEAGG---- 1511
Human 840 PPATKA---DSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQS 901
.||.| .|....:.:..:|..|. |.|:..:...:.........:||....:|......|
Fly 1512 -NATSAMTNSSTSGSMNISNSHGLKA---NAKDGSMMAKTSMASTSSASVVVTSTPSASSSSLSS 1572
Human 902 -------------------DNDSSATCSADEDVDGEP-----------ERQRMFPMDSKPSLLN- 935
.:.|:||.:|.......| ....:..:|.|..|.:
Fly 1573 ASSMLLISAASVMSTAAGATSSSTATTTATASAISLPLLADGSGNSMVNANEILALDGKDKLASC 1637
Human 936 -----------------------------PTGSILVSS---------------PLKPNPLD---- 952
|.|:.:.:| |..|||.|
Fly 1638 FVCKAEACPRTRPLKKGRGQQYGIPDETIPAGARVCNSCQCKSVRSRYPNCPLPTCPNPKDRAQR 1702
Human 953 ---LPQLQHRAA-----------VIPPMVS--CTPC------------NIPIG------------ 977
:|......| .|||..: |:.| |:..|
Fly 1703 LRNIPSRLFELAPEVRDPLMAEFQIPPHATRCCSACLMRIRRKLDPQLNLTDGSSGGAGSGSGGD 1767
Human 978 -TPVSGYAL------------------YQRH-----IKAMHESALLEEQRQRQEQ---------- 1008
|.||..:. .||| :|...:....::|:|:|:|
Fly 1768 ETDVSTSSCDEREPGGSDTASVESPENLQRHKSLTMVKQQQQQQQQQQQQQQQQQQQQQQQLSQP 1832
Human 1009 ------------------------IDLECRSSTS----------------PCGTSKSPNR----- 1028
|....|.|:. |....::|.:
Fly 1833 QPPPPAPQQQKGSSGRGGDQGTPLIITPTRMSSKSGSGGAQTAGDNERLLPPAAGQAPKKQKTSE 1897
Human 1029 EWEGKS------------------------------------------VAYM-------PYAEVK 1044
|::..: ||.| |.....
Fly 1898 EYDSSATETADEENENSPANRQSPKVLFHGHGHGHGGHANNVAGLQPPVANMGTGGGVQPGGAAG 1962
Human 1045 RALEQEAQMHNTAARSASPCRLS--PREVSKAAPQP----------------------------- 1078
:.:.....|...|..:...|..| .|.:....|||
Fly 1963 QQVNGPISMRREAVNNVQDCVFSVIERSLKHKGPQPKGGQGQQQGQGQGQGQGQGQTPGQSQSPS 2027
Human 1079 ------------------DMSAAR-YSVPPVL-------QPA----PHQVITNLPEG--VRLPTT 1111
:::..| |...|.: |.| |.....:||.| |:..||
Fly 2028 QQQQQQQQQQSANNLERKELTIVREYRQDPGILKQQQQQQQAGGAPPTSAAGSLPHGTSVQKLTT 2092
Human 1112 RP--TRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLT-----SHNQASYTQETPKPSVGS 1169
|| ..||||..|.:.|:.. ..|| :.||..:..| || :|.
Fly 2093 RPAAVAPPPPAHPLTPTSTG-------CAGS-NNGTSDSLATLSVVNSH-------------MGM 2136
Human 1170 ISLGLPRQQESAKSA---------TLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQE 1225
:.:|.|.....|.|| ..|.:|....|.:|..............|.::.....|..:
Fly 2137 VGIGHPGPMAHASSAGGIGVDKATITPVVKSSSGSSKSGGGSASSHSTATPPETIIYNVPVAHPQ 2201
Human 1226 GSITRGTPTSKISVESIPSLRGSITQGTPALPQTGI-----------PTEALVKGSISRMPIEDS 1279
||.|.. |..|:.....|.|| .||.||... |....:..||.:.|.:..
Fly 2202 ----RGIPPP--SQHSVHPAHPSHTQ-HPAHPQHSSHGQHTQLQVPEPEPQTLDLSIKKPPRDGH 2259
Human 1280 SPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGNIKQGMSM 1344
||..|...::|.| .|..| .:..:...|...| .:|:|....| |.:.:|.::
Fly 2260 SPHTGAGGSSSSG----SGSGG-----PSSSDRHHGPPPP----TMSMKHIVRS--GGMYRGDTV 2309
Human 1345 RESPVSAPLE--------------GLICRALPRGSPHSDLKERTV-------LSGSIMQG--TPR 1386
....::||.. |::...|| |.|.|.|..:.| :|| || .||
Fly 2310 TVPSLAAPSSYLYPTRSVKTIGGGGVVPGVLP-GVPGSALYLQPVPVPVPISISG---QGQLPPR 2370
Human 1387 ATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGITTIKEMGRSIHEIP------------ 1439
| |...|.| || .||.:.::|
Fly 2371 A-------GQPPPAQ-----PP----------------------SGRGVAKVPPKLSPQQAHHLH 2401
Human 1440 ------------RQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLIT 1492
:|....|:.::.....|....:..|||:.|||. |::.|..|.|...:...
Fly 2402 PSHGHSPSQQQQQQQQQQQQQQQQAAAAQQQLLVKSGSITHGTPA---NSAQQQIIVHAPATAAA 2463
Human 1493 GPSKLSRGMPP------LEIVPENIKVVERGKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAP 1551
.||.| :.| .:..||.:..|..| |.:...:|.|:....| ||..|
Fly 2464 APSSL---LSPKFDGLVRQTTPEGVGSVGPG-------GASGSGKHGSITQGTP------LHMPP 2512
Human 1552 KAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLTPTQRESIPAK 1616
....::|...||..:..|.|| :.....|.: |.|..::|.|..
Fly 2513 ---------HHLESKRPYESYYKSSQRHSP----------AQQPGGNQQ----LPPPPQQSSPQA 2554
Human 1617 SPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGY 1681
.|..|....|| .|:.| ||..|.
Fly 2555 PPPQGYGVGVS----------------------------SPYAR---------------SPFAGV 2576
Human 1682 PSQYQLYAMENTRQTILNDYITSQQM---------QVNLRPDVARGL----------------SP 1721
..|.|:. :|||.:::|||||||| |...:.:::||. ||
Fly 2577 VEQPQVL---STRQIVMHDYITSQQMQGQQQQQQQQQQQQRNMSRGSSASGGGGGGGSDKESPSP 2638
Human 1722 REQ----------------PLGLP-YPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYI---- 1765
|.. |.|.| |.:.....|..|..|: || .|||..|...|
Fly 2639 RNSVGSASGFAYGGDKESAPRGRPEYSSRASPADHVNSTPS---PH----RTPPPQRQGVIQRHN 2696
Human 1766 -----------PGTQITFPPRPYNSASMSPGHPTHLAAAASAEREREREREKERERERIAAASSD 1819
|.:::..||..|..: ||....:....|.::.:.....:::.:
Fly 2697 TGSKPPSPAAPPPSRMHMPPYQYAPS----GHDALASFVDVAVQQPQLPVPSQKDDK-------- 2749
Human 1820 LYLRPG-SEQPGR-PGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTA----QLR 1878
.|| |..||: ||| |....||| ..|....| |..|..||| :.|
Fly 2750 ---SPGPSTAPGQVPGS-GPPLGPSP----------LPPHAVVG-----VAQPPPPTAHHDQRYR 2795
Human 1879 IMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSK----------------TKESK 1927
.:.|.....::.|...|.:.:..:..:||.||... |||.:| .::.:
Fly 2796 DLTLHHHHHTLVQQQIAQQQHYRSLNVAAQVDMQR---QMDQAKRVMRHQQHQVQQQQQQQQQQQ 2857
Human 1928 HEAA-----RLEENLRSRSAAVSEQQQLEQKTLEVEK---------------------------- 1959
|..| .::|.:|.|......:::.||:..|.|:
Fly 2858 HNHALERDREMQERMRERDREREREREREQRERERERERERERERERREQDRARRVVAEEREHDS 2922
Human 1960 RSVQCLYT------SSAFPSGKPQP----HSSVVYSEAGKDKGPPPKSRYEEELRTRGKTT---- 2010
|.::.::. |.....|.|.| .:|| .|.|..:..|.:.|.....:..|...
Fly 2923 RRMERMFAGNVVTGSGGAGGGGPSPGQFLRASV--PETGPPRSIPDRERESYYRQAHGGPAPEDT 2985
Human 2011 ---ITAANFIDVIITRQIASDKDA-----RE-------------RGSQSSDSSSSLSSHRYETPS 2054
::|.:.||.||..:|....|| || |||.|...:.:.|| |:
Fly 2986 PGQLSAQSLIDAIIKHEINRSNDATAGPGREFPRPSFVHAPLPPRGSGSGGGTGTRSS-----PA 3045
Human 2055 DAIEVI-----------------------SPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEG 2096
:.:..: .|:||.:|....:...|..:..|..|.....:|.:.
Fly 3046 NVLHPMYLRDLRQPLDGGAGSMLTAENNGKPSSSGSPSVINIDLDQERISAAAAAVAQQQQQQQA 3110
Human 2097 PLHHYRPQQESPSPQ---QQLPPSSQAEGMGQVP-RTH-RLITLADHICQIITQDFARNQVSSQT 2156
| .|.|.|.|.. |...|:|||.|....| :.| :.||..:....|||.|:..|
Fly 3111 P----PPSQSSQSRSVHGQLRTPTSQAGGSAPSPQQIHTKSITFGELTDSIITSDYGTN------ 3165
Human 2157 PQ-QPPTSTF-QNSPSALVSTPVRTKTSNRYSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGK 2219
|. :||...: |.:.|.| .|.|.| .||...:...::.|| |:...:....:...::..:
Fly 3166 PHLRPPYMAYLQETQSIL--PPDRWK-QNRRMQQKAEEAKHH----SQQQQQQQHQQQHHAQQQQ 3223
Human 2220 SPERSHVSSEPYEPISPPQVPVVHEKQDSLLLLSQRGAEP--AEQRNDARSPGS----------- 2271
..::.|.:.:.: ||:|. :..|:.| |.|...:..|||
Fly 3224 QQQQQHHAQQHH-----PQMPG-----------TGSGSAPGGAGQGGGSGGPGSGGGGAGRASTP 3272
Human 2272 ------ISYLPSFFTKLENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGS 2330
|..:| :..||...:.:..:...:.::|.|........|...:......|.||.
Fly 3273 GEDGRNIIRMP------QAVSPRKFNHEMMLHHVMGTTGAGGEAGQFFLPSRVVLPEQRGTPSGG 3331
Human 2331 VSSRGHSFADPASNLG---LEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETR 2392
..:.| ...|.|..| :|..::..: ..||...:|. ..|.:| |.|
Fly 3332 GGAPG--AGGPGSGGGATTIEKYVKTRI-----------AEVMRDDIGY---GKNRTV----EVR 3376
Human 2393 REE---GDPSPHSGGVCKPKLISKSN----------SRKSKSPIPGQGYLGTERPSSVSSVHSEG 2444
.|: .|...||........::.:. ..:||.|.|.:..:..:.|:....|.:.|
Fly 3377 TEDEVTADMVAHSHAAVHAAHVAHAAHVAHAAAMELQHRSKEPPPPEISVSRKTPNQYEVVDASG 3441
Human 2445 DYHRQTPGWAWEDRPSSTGSTQFPYNPLTMRMLSSTPPTPIAC--APSAVNQAAPHQQNRIWERE 2507
.|.....:.....|...|...||:|.......||...|.:. .|.|.....|||..::..:.
Fly 3442 --RRSAGSGSVSVSVSGANSHHSPYHPPAAAYAPSTYAFPYSALNVPGAAGGLPPHQPLQLAHQA 3504
Human 2508 PAP 2510
.||
Fly 3505 VAP 3507
| 
