DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDIA4 and CaBP1

DIOPT Version :9

Sequence 1:	NP_001358173.1	Gene:	PDIA4 / 9601	HGNCID:	30167	Length:	646	Species:	Homo sapiens
Sequence 2:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	128/410 - (31%)
Similarity:	191/410 - (46%)	Gaps:	76/410 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    62 NGVLVLNDANFDNFVADKDTV-LLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSA 125
            :||:.|..:|||..|...|.: ::||||||||||:...|||:|:|..||.   .:.|..::|.:.
  Fly    25 DGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALKG---VVKVGSVNADAD 86

Human   126 SVLASRFDVSGYPTIKIL--KKGQAVDYEGSRTQE--------EIVAKVREV--------SQPDW 172
            |.|:.:|.|.|:|||||.  .|....||.|.||.:        |:..||:.|        |....
  Fly    87 STLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKKKVQGVLGGGGGSSSGGSG 151

Human   173 TPPPEVTLVLTKENFDE-VVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVD 236
            :...:..:.||::|||: |:|..||.||||:||||||||.||||:.||||||..:   :.|..:|
  Fly   152 SSSGDDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKELKGK---VKLGALD 213

Human   237 ATAETDLAKRFDVSGYPTLKIF-----RKGRPYDYNGPREKYGIVDYMIEQ--SGPPSKEILTL- 293
            |||....|..::|.||||:|.|     |.....:|:|.|....||.:..::  :..|:.|::.:
  Fly   214 ATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSWASDKHVANVPAPELIEII 278

Human   294 -KQVQEFLKDGDDVIIIGVFKGESD---PAYQQYQDAANNLREDYKFHH--------------TF 340
             :...|...:|..:.::.|.....|   ....::.|....|.|.:|...              ..
  Fly   279 NESTFETACEGKPLCVVSVLPHILDCDAKCRNKFLDTLRTLGEKFKQKQWGWAWAEGGQQLALEE 343

Human   341 STEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHMMDVQQGSTQDSAIKDFV--LKYALPLVGHRKV 403
            |.|:..|   ....:.|:..:|.:         ..|.:||.....|.:|:  :.|..   ||...
  Fly   344 SLEVGGF---GYPAMAVVNFKKMK---------FSVLKGSFSKDGINEFLRDISYGR---GHTAP 393

Human   404 SNDAKRYTRRPLVVVYYSVD 423
            ...||    :|.:|   |||
  Fly   394 VRGAK----KPAIV---SVD 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDIA4	NP_001358173.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..58
		pdi_dom	67..168	CDD:273454	45/119 (38%)
		CXXC. /evidence=ECO:0000250\|UniProtKB:P08003	91..94		2/2 (100%)
		ER_PDI_fam	177..641	CDD:273457	80/276 (29%)
		CXXC. /evidence=ECO:0000250\|UniProtKB:P08003	556..559
		Prevents secretion from ER	643..646
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	41/95 (43%)
		PDI_a_P5	157..262	CDD:239299	50/107 (47%)
		Thioredoxin_6	190..383	CDD:290560	50/207 (24%)
		P5_C	271..400	CDD:239281	24/147 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910