Protein Alignment PDIA4 and CaBP1

DIOPT Version :10

• Sequence 1: NP_001358173.1
• Gene: PDIA4 / 9601
• HGNCID: 30167
• Length: 646
• Species: Homo sapiens
• Sequence 2: NP_609792.1
• Gene: CaBP1 / 34976
• FlyBaseID: FBgn0025678
• Length: 433
• Species: Drosophila melanogaster
• Alignment Length: 410
• Identity: 128/410 - (31%)
• Similarity: 191/410 - (46%)
• Gaps: 76/410 - (18%)

Human    62 NGVLVLNDANFDNFVADKDTV-LLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSA 125
            :||:.|..:|||..|...|.: ::||||||||||:...|||:|:|..||.   .:.|..::|.:.
  Fly    25 DGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALKG---VVKVGSVNADAD 86

Human   126 SVLASRFDVSGYPTIKIL--KKGQAVDYEGSRTQE--------EIVAKVREV--------SQPDW 172
            |.|:.:|.|.|:|||||.  .|....||.|.||.:        |:..||:.|        |....
  Fly    87 STLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKKKVQGVLGGGGGSSSGGSG 151

Human   173 TPPPEVTLVLTKENFDE-VVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVD 236
            :...:..:.||::|||: |:|..||.||||:||||||||.||||:.||||||..:   :.|..:|
  Fly   152 SSSGDDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKELKGK---VKLGALD 213

Human   237 ATAETDLAKRFDVSGYPTLKIF-----RKGRPYDYNGPREKYGIVDYMIEQ--SGPPSKEILTL- 293
            |||....|..::|.||||:|.|     |.....:|:|.|....||.:..::  :..|:.|::.:
  Fly   214 ATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSWASDKHVANVPAPELIEII 278

Human   294 -KQVQEFLKDGDDVIIIGVFKGESD---PAYQQYQDAANNLREDYKFHH--------------TF 340
             :...|...:|..:.::.|.....|   ....::.|....|.|.:|...              ..
  Fly   279 NESTFETACEGKPLCVVSVLPHILDCDAKCRNKFLDTLRTLGEKFKQKQWGWAWAEGGQQLALEE 343

Human   341 STEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHMMDVQQGSTQDSAIKDFV--LKYALPLVGHRKV 403
            |.|:..|   ....:.|:..:|.:         ..|.:||.....|.:|:  :.|..   ||...
  Fly   344 SLEVGGF---GYPAMAVVNFKKMK---------FSVLKGSFSKDGINEFLRDISYGR---GHTAP 393

Human   404 SNDAKRYTRRPLVVVYYSVD 423
            ...||    :|.:|   |||
  Fly   394 VRGAK----KPAIV---SVD 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDIA4	NP_001358173.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..58
		pdi_dom	67..168	CDD:273454	45/119 (38%)
		CXXC. /evidence=ECO:0000250|UniProtKB:P08003	91..94		2/2 (100%)
		ER_PDI_fam	177..641	CDD:273457	80/276 (29%)
		CXXC. /evidence=ECO:0000250|UniProtKB:P08003	556..559
		Prevents secretion from ER	643..646
CaBP1	NP_609792.1	PDI_a_P5	26..119	CDD:239299	41/95 (43%)
		PDI_a_P5	157..262	CDD:239299	50/107 (47%)
		P5_C	271..400	CDD:239281	24/147 (16%)