Protein Alignment PRDX6 and Prx2

DIOPT Version :10

• Sequence 1: NP_004896.1
• Gene: PRDX6 / 9588
• HGNCID: 16753
• Length: 224
• Species: Homo sapiens
• Sequence 2: NP_477510.1
• Gene: Prx2 / 53578
• FlyBaseID: FBgn0040309
• Length: 194
• Species: Drosophila melanogaster
• Alignment Length: 191
• Identity: 61/191 - (31%)
• Similarity: 94/191 - (49%)
• Gaps: 15/191 - (7%)

Human    11 APNFEANTTVG----RIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIAL 71
            ||.|.....|.    .|:..|:.| .:.:||.:|.|||.||.||:...::.|.||.|.|.::|..
  Fly     8 APAFAGTAVVNGVFKDIKLSDYKG-KYLVLFFYPLDFTFVCPTEIIAFSESAAEFRKINCEVIGC 71

Human    72 SIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFV 136
            |.||...||||   ||....:.....:..|::.|::.::|...|:||    :|.|:|.  |.:|:
  Fly    72 STDSQFTHLAW---INTPRKQGGLGSMDIPLLADKSMKVARDYGVLD----EETGIPF--RGLFI 127

Human   137 FGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVL-PTIPEE 196
            ....:.|:...:.....||:.:|.||:|.:.|.|.:.....|.:||.|...||. ||..:|
  Fly   128 IDDKQNLRQITVNDLPVGRSVEETLRLVQAFQYTDKYGEVCPANWKPGQKTMVADPTKSKE 188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRDX6	NP_004896.1	PRX_1cys	7..222	CDD:239314	61/191 (32%)
		Required and sufficient for targeting to lysosomes and lamellar bodies. /evidence=ECO:0000250|UniProtKB:O35244	31..40		2/8 (25%)
Prx2	NP_477510.1	PRX_Typ2cys	4..175	CDD:239313	55/176 (31%)