Protein Alignment PRDX6 and Prx1

DIOPT Version :10

• Sequence 1: NP_004896.1
• Gene: PRDX6 / 9588
• HGNCID: 16753
• Length: 224
• Species: Homo sapiens
• Sequence 2: NP_648759.1
• Gene: Prx1 / 39658
• FlyBaseID: FBgn0036490
• Length: 196
• Species: Drosophila melanogaster
• Alignment Length: 197
• Identity: 60/197 - (30%)
• Similarity: 96/197 - (48%)
• Gaps: 14/197 - (7%)

Human     5 LLLGDVAPNFEANTTVGRIRFHDF-LGDSWG---ILFSHPRDFTPVCTTELGRAAKLAPEFAKRN 65
            |.:..|||||..|..|.. .:.:| |.|..|   :|..:|.||:.||.|||...:..||||....
  Fly     4 LNINQVAPNFTTNAVVSG-GYRNFALTDLRGRYVLLVFYPADFSYVCPTELQAFSDRAPEFRNVG 67

Human    66 VKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVT 130
            .:::|.|.||...|.||   :|.........:|..|::.|:|.::|...|:||    ::.|:.:
  Fly    68 CEVLACSTDSHFVHCAW---MNTPRKNGGLGELDIPLLADKNMKIARDYGVLD----EDTGLAL- 124

Human   131 ARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPE 195
             |.:|:...:.:::...:.....||:.||.||:|.:.|.:.|.....||:|:.|...|......:
  Fly   125 -RALFIIDREGRIRQITVNDMGVGRSVDEALRLVQAFQFSDEFGEVCPVNWRPGAKTMKADATGK 188

Human   196 EE 197
            ||
  Fly   189 EE 190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRDX6	NP_004896.1	PRX_1cys	7..222	CDD:239314	59/195 (30%)
		Required and sufficient for targeting to lysosomes and lamellar bodies. /evidence=ECO:0000250|UniProtKB:O35244	31..40		3/11 (27%)
Prx1	NP_648759.1	AhpC	2..193	CDD:440219	60/197 (30%)