Protein Alignment PRDX6 and Prx6b

DIOPT Version :10

• Sequence 1: NP_004896.1
• Gene: PRDX6 / 9588
• HGNCID: 16753
• Length: 224
• Species: Homo sapiens
• Sequence 2: NP_724931.1
• Gene: Prx6b / 246663
• FlyBaseID: FBgn0033520
• Length: 220
• Species: Drosophila melanogaster
• Alignment Length: 216
• Identity: 116/216 - (53%)
• Similarity: 149/216 - (68%)
• Gaps: 2/216 - (0%)

Human     7 LGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIAL 71
            ||...|||||:||.|.|:||::.|:||.:|||||.||||||||||||.|...|||||||.|.:|.
  Fly     3 LGQTVPNFEADTTKGPIKFHEWQGNSWVVLFSHPADFTPVCTTELGRIAVHQPEFAKRNTKCLAH 67

Human    72 SIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFV 136
            |:|::..|:.|..||.:|..:.|.: .|:|||.|..|:||:.|||||..:|.:..:..|.|.:|:
  Fly    68 SVDALNSHVDWVNDIKSYCLDIPGD-FPYPIIADPTRDLAVTLGMLDEEQKKDPEVGKTIRALFI 131

Human   137 FGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAE-KRVATPVDWKDGDSVMVLPTIPEEEAKK 200
            ..||.|::||:.||.:||||.|||||.:.|||||.. |.||||.:|..|..||:|||:.:|||.|
  Fly   132 ISPDHKVRLSMFYPMSTGRNVDEILRTIDSLQLTDRLKVVATPANWTPGTKVMILPTVTDEEAHK 196

Human   201 LFPKGVFTKELPSGKKYLRYT 221
            |||||.....:|||..|:|.|
  Fly   197 LFPKGFDKVSMPSGVNYVRTT 217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRDX6	NP_004896.1	PRX_1cys	7..222	CDD:239314	116/216 (54%)
		Required and sufficient for targeting to lysosomes and lamellar bodies. /evidence=ECO:0000250|UniProtKB:O35244	31..40		5/8 (63%)
Prx6b	NP_724931.1	PRX_1cys	3..218	CDD:239314	116/216 (54%)