DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF20B and klp9

DIOPT Version :9

Sequence 1:	NP_001271188.1	Gene:	KIF20B / 9585	HGNCID:	7212	Length:	1820	Species:	Homo sapiens
Sequence 2:	NP_001342762.1	Gene:	klp9 / 2539778	PomBaseID:	SPBC15D4.01c	Length:	633	Species:	Schizosaccharomyces pombe

Alignment Length:	714	Identity:	187/714 - (26%)
Similarity:	317/714 - (44%)	Gaps:	156/714 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    59 LQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKVFGPAT 123
            :|:.||::....|.......|.:.:|:...::|:.|:.  ......|..:..:|.||:|||.|:.
pombe     2 IQIFLRVKKAQPSSDASNKYGFLTVLNDYEILLESPED--SHAYRVSKSKTLEKASFTKVFPPSC 64

Human   124 TQKEFFQGCIMQPVKD-LLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLFDSLQERL 187
            ||.:.|.......:.| |:.....|:||.|::.:|||||..|..:..|:....|:.||.:::.|.
pombe    65 TQLDVFSTICAPLIADSLVNMNDTLLFTLGVSGAGKTYTLFGPSDRPGVAFLALDALFYAIKGRE 129

Human   188 YTKMNLKPHRSREYLRLSSEQEKEEIASKSALLR--QIKEVTVHNDSDDTLYGSLTNSLNISEFE 250
            .:...:      |:||  |:.||.:|...|..||  ...::.|.|..   .|.|     :..:.|
pombe   130 ASPQTV------EFLR--SQLEKCKIVEASKFLRGEAPLDIKVPNTE---YYAS-----HFPKIE 178

Human   251 ESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRL----SQDVKGYSF 311
            |  |:|:           :::::||.||||:.|:|| :..:|.|..|..|.|    :.|.|.
pombe   179 E--KNYQ-----------YAIYLSFAEIYNDRIFDL-LEKASFFGHRHALSLKKSSTSDKKS--- 226

Human   312 IKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDSEMSRVIRVSEL 376
            |..:|.:.||::.|||:|::..::.:....||.|:.|||||.|.::::.::  ...|......::
pombe   227 IAGIQKVFVSNTTEAYKLIQKVLQLRKSTSTKSNSVSSRSHLIMSIELFKV--CTKSNKFESCQI 289

Human   377 SLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQH-VPFRESKLTH-- 438
            .|.||||||||...:..|..|||..:||.||||||:|:..|:...:.|  || :|||:||||.
pombe   290 DLVDLAGSERTRSAETSGLLLREGASINRSLLTLGQCLEALRRKHEGK--QHIIPFRQSKLTELL 352

Human   439 YFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVS 503
            :.....:|...|.|:|||.. :.::||...|:::||.|:::..|                    .
pombe   353 FHSGHLSGLAGINMLVNIDP-FGSFDENAQVMRYSANAREILPP--------------------P 396

Human   504 LDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFI 568
            |:.||.|:         |..:||            |:.::.|.:  ||.|...|::..:||
pombe   397 LNENSGSQ---------SPSHSL------------LQKSKNTSS--TKALTSHLEQLQQEN---- 434

Human   569 SHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQER----E 629
                        :.|:..|.:...|.:.||::||:::|:|..:..::.|..|...||:|.    |
pombe   435 ------------QQLRMLLADADSEMMNLEYEIRQQMTREMEERVSEVERTFLTKLLEESAQGIE 487

Human   630 ILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEETHNYVGFEDIIDSLQDNVADIKKQAE 694
            ..::..|:.....|.|      ::|          .:|:|......|.||:.|.:.:..:::::
pombe   488 YTDQKLEKMGGWMKKL------QDE----------NSEKTETIAQLEQIIEELHEELRSLEEES- 535

Human   695 IAHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKK 758
                                     ||...|..:.| .:.|...:|...|....|||..|.|.|
pombe   536 -------------------------IKESSATQQNE-NQHKRSSRKLLYEDKQAIQEAHTINTK 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF20B	NP_001271188.1	KISc_KIF23_like	57..477	CDD:276819	132/427 (31%)
		Kinesin	64..479	CDD:278646	131/424 (31%)
		Smc	629..1455	CDD:224117	24/130 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	829..866
		Necessary and sufficient for interaction with SHTN1. /evidence=ECO:0000250\|UniProtKB:Q80WE4	1050..1107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1247..1275
		DUF342	<1268..1357	CDD:302792
		Interaction with PIN1. /evidence=ECO:0000269\|PubMed:11470801	1560..1820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1760..1781
klp9	NP_001342762.1	KIP1	40..633	CDD:227392	179/674 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	156	1.000	Domainoid score	I1178
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm53564
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R641
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.040