DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM39 and SGN1

DIOPT Version :9

Sequence 1:	NP_909122.1	Gene:	RBM39 / 9584	HGNCID:	15923	Length:	530	Species:	Homo sapiens
Sequence 2:	NP_012266.1	Gene:	SGN1 / 854817	SGDID:	S000001440	Length:	250	Species:	Saccharomyces cerevisiae

Alignment Length:	113	Identity:	39/113 - (34%)
Similarity:	62/113 - (54%)	Gaps:	12/113 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   220 GVPIIVQ-ASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMM 283
            |.|.:.| .|:.||:     |:.|:..|..   ::||::..::|.:.:...|:..|:|:.|.|:.
Yeast    41 GTPQVSQKLSKEEKH-----AHQLEADSRS---IFVGNITPDVTPEQIEDHFKDCGQIKRITLLY 97

Human   284 DSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTD 331
            |..||..||||:|.|......:||| ||||.||.|:.:.|..  :||:
Yeast    98 DRNTGTPKGYGYIEFESPAYREKAL-QLNGGELKGKKIAVSR--KRTN 142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM39	NP_909122.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..146
		SF-CC1	46..518	CDD:273721	39/113 (35%)
		Interaction with JUN. /evidence=ECO:0000250\|UniProtKB:Q8VH51	291..406		19/41 (46%)
		Activating domain. /evidence=ECO:0000250\|UniProtKB:Q8VH51	291..355		19/41 (46%)
		Interaction with ESR1 and ESR2. /evidence=ECO:0000250\|UniProtKB:Q8VH51	355..406
		Interaction with NCOA6. /evidence=ECO:0000250\|UniProtKB:Q8VH51	406..530
SGN1	NP_012266.1	RRM	<16..248	CDD:223796	39/113 (35%)
SGN1	NP_012266.1	RRM_II_PABPs	65..137	CDD:409747	27/75 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910