DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM39 and RNA15

DIOPT Version :9

Sequence 1:	NP_909122.1	Gene:	RBM39 / 9584	HGNCID:	15923	Length:	530	Species:	Homo sapiens
Sequence 2:	NP_011471.1	Gene:	RNA15 / 852838	SGDID:	S000003012	Length:	296	Species:	Saccharomyces cerevisiae

Alignment Length:	291	Identity:	74/291 - (25%)
Similarity:	114/291 - (39%)	Gaps:	89/291 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   241 NLQKG-SAG-----PMR-LYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITF 298
            |.|.| :||     |.| :|:||:.::.||:.:..:....|.:.::::|.|.:|||||||.||.|
Yeast     2 NRQSGVNAGVQNNPPSRVVYLGSIPYDQTEEQILDLCSNVGPVINLKMMFDPQTGRSKGYAFIEF 66

Human   299 SDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSAS--------------------------- 336
            .|.|.:..|:..|||::|..|.:|.|: :..:|.|..|
Yeast    67 RDLESSASAVRNLNGYQLGSRFLKCGY-SSNSDISGVSQQQQQQYNNINGNNNNNGNNNNNSNGP 130

Human   337 --------SFLDS--DELERTGIDLG---TTGRLQLMARLA---------------EGTGLQIPP 373
                    :||..  .||. :|||:.   ||..:.:.:.||               |.|... |.
Yeast   131 DFQNSGNANFLSQKFPELP-SGIDVNINMTTPAMMISSELAKKPKEVQLKFLQKFQEWTRAH-PE 193

Human   374 AAQQALQMSGSLAF--------GAVAEFSFVIDLQTRLSQQTEASAL-----------AAAASVQ 419
            .|...|::...|:|        ..:.:...:|.|.:|  .|.||||.           |.....:
Yeast   194 DAVSLLELCPQLSFVTAELLLTNGICKVDDLIPLASR--PQEEASATNNNSVNEVVDPAVLNKQK 256

Human   420 PLATQCFQLSN---MFNPQTEEEVGWDTEIK 447
            .|..|..||::   ...|..|....||.:.|
Yeast   257 ELLKQVLQLNDSQISILPDDERMAIWDLKQK 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM39	NP_909122.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..146
		SF-CC1	46..518	CDD:273721	74/291 (25%)
		Interaction with JUN. /evidence=ECO:0000250\|UniProtKB:Q8VH51	291..406		40/177 (23%)
		Activating domain. /evidence=ECO:0000250\|UniProtKB:Q8VH51	291..355		27/103 (26%)
		Interaction with ESR1 and ESR2. /evidence=ECO:0000250\|UniProtKB:Q8VH51	355..406		12/73 (16%)
		Interaction with NCOA6. /evidence=ECO:0000250\|UniProtKB:Q8VH51	406..530		15/56 (27%)
RNA15	NP_011471.1	RRM_CSTF2_RNA15_like	18..94	CDD:409832	29/76 (38%)
RNA15	NP_011471.1	CSTF_C	255..291	CDD:405061	9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910