DRSC/TRiP Functional Genomics Resources

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Protein Alignment CDC42BPB and Rok

DIOPT Version :9

Sequence 1:XP_005268284.1 Gene:CDC42BPB / 9578 HGNCID:1738 Length:1728 Species:Homo sapiens
Sequence 2:NP_536796.2 Gene:Rok / 43916 FlyBaseID:FBgn0026181 Length:1390 Species:Drosophila melanogaster


Alignment Length:1364 Identity:382/1364 - (28%)
Similarity:655/1364 - (48%) Gaps:249/1364 - (18%)


- Green bases have known domain annotations that are detailed below.


Human     6 RLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQ 70
            |...||:.:.|    ..|..:|:.|||.:..|.::|.|.:|||.|.:.::....||....:.:::
  Fly    21 RANTLEREMRD----PTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLR 81

Human    71 LHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW 135
            ::.|||..||:||.||||||.:|:.|::.::||||.|:|:||:||.::|.|.|||.::.:.:.:|
  Fly    82 MNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEW 146

Human   136 ITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRD 200
            |..||:||||..:||:|||:..|||:::|:..::  :||..|.||..|:|||:|:||.:.:||||
  Fly   147 IVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHRD 209

Human   201 IKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGM-GKYGPECDW 264
            :||||:|||..||::|||||:|::|..:|.|.||.|||||||||||:||:  .|: .:||.||||
  Fly   210 VKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQS--QGVDNEYGRECDW 272

Human   265 WSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLG 329
            ||:|:.:||||:|||||||:|||.||||||:|:....||..| ::||:||.||:..:..|.:|||
  Fly   273 WSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEV-EISEQAKALIRAFLTDRTQRLG 336

Human   330 QNGIEDFKKHAFFEGLNW--ENIRNLEAPYIPDVSSPSDTSNF-DVDDDVLRNTEILPPGSHTGF 391
            :.||||.|.|.||....|  :|||....|.:|::||..||.|| |::.|. :..|:.|...  ||
  Fly   337 RYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDE-KPEEVFPVPK--GF 398

Human   392 SGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTL---TKDEDVQ---------------------- 431
            .|.||||||||:|.:         ..::.|:|:   :|:.:|.                      
  Fly   399 DGNHLPFIGFTYTGD---------YQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNS 454

Human   432 ---RDLEHSLQMEAYERRIRRLEQ------EKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEI 487
               :.||..|:.|  ..|...|||      :::||..|.:...|.:.|.:....||...|....:
  Fly   455 NELKRLEALLERE--RGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAM 517

Human   488 KKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQ-------HRVVRQEKEEL 545
            :|:.:|||..|...|.....:|.||:....|....:...::..||||       ::...:..::|
  Fly   518 QKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKL 582

Human   546 HKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRA---QKQKVSRQLRDKEEEMEV 607
            .|...|....:|||.::::|.........:...||.:..|||:|   |::.:..||::..:|.| 
  Fly   583 KKHNAELDFTVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAE- 646

Human   608 ATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELE--------AL 664
                               .:::..::|......:|:|.:|.:....::: |:||        .|
  Fly   647 -------------------NKMQTLINDIERTMCREQKAQEDNRALLEKI-SDLEKAHAGLDFEL 691

Human   665 KVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLAL 729
            |..||        .:|||: |...|.||      ..||.||.:::.|||.::.::::.:|.::  
  Fly   692 KAAQG--------RYQQEV-KAHQETEK------SRLVSREEANLQEVKALQSKLNEEKSARI-- 739

Human   730 QKEILMLKDKLEKSKRERHN-EMEEAVGTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQ 793
                          |.::|: |.|..:..:...|.:.:..|.....:...|:||:.:...:|..:
  Fly   740 --------------KADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQLDQE 790

Human   794 NRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDAR------------GYLQALASKMTEEL 846
            :.:....|.:|:.....|||..::..::.:.:|.:::|:            .:.:|||:  ..||
  Fly   791 HSKRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDLTQLKSTHHEALAN--NREL 853

Human   847 EA-LRSSSLGSR------------TLDPLWKVRRSQKLDMSARLELQSAL---EAEIRAKQLVQE 895
            :| |.:....||            :.:.|.|:...::..:|.:.::|.|:   ::|..|:.:.:|
  Fly   854 QAQLEAEQCFSRLYKTQANENREESAERLSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEE 918

Human   896 ELRKVKDANLTLESKLKDSEAKNRELLEEME---ILKKKMEEKFRADTGLKLPDFQDSIFEYFNT 957
            .:..::......|.:|||...|:|..:...|   ...|:.|.:.....|.|..:::|.:.::   
  Fly   919 TVADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQH--- 980

Human   958 APLAHDLTFRDSLSSSSASSLL------------AFWEETSSASEQETQAPKPEASPSMSVAASE 1010
            .....:|....|......:.||            |..:.....:.:::..||.:.....:....:
  Fly   981 KKQQEELALMRSSKDEEITKLLDKCKNEVLLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRK 1045

Human  1011 QQEDMARPPQRPSAVPLPTTQALALAGPKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEV 1075
            ::::|.|..|.             |:..:.|.:|..:|.......|:....|...::.:      
  Fly  1046 KEKEMRRLQQE-------------LSQERDKFNQLLLKHQDLQQLCAEEQQLKQKMVME------ 1091

Human  1076 CSFACHVSCKDGAPQV---------------CPIPPEQSKRPLGVDVQRGIGTAYKGHVKVPKPT 1125
                  :.||  |.::               ....||.|:....:.:.:  .:.::|.:.||...
  Fly  1092 ------IDCK--ATEIENLQSKLNETASLSSADNDPEDSQHSSLLSLTQ--DSVFEGWLSVPNKQ 1146

Human  1126 GVKK--GWQRAYAVVCDCKLFLY--DLPEGKSTQPGVIASQVLDLRDDEFSVSSVLASDVIHATR 1186
            ..::  ||:|.|.:|...|:..|  |:.:..:|.    |..:||| ...:.|.||...|||.|..
  Fly  1147 NRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTD----AVLILDL-SKVYHVRSVTQGDVIRADA 1206

Human  1187 RDIPCIFRVTASLLGA---PSKTSSL--LILTENENEKRKWVGILEGLQSILHKNRLRNQVVHV 1245
            ::||.||::..:..||   |.:.|.|  .:|..|.||:|.        .:|:||.   ::.||:
  Fly  1207 KEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNCNEERP--------GTIVHKG---HEFVHI 1259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDC42BPBXP_005268284.1 STKc_MRCK_beta 3..411 CDD:270774 194/408 (48%)
S_TKc 76..342 CDD:214567 144/266 (54%)
TPH 426..786 CDD:290579 85/409 (21%)
KELK 528..606 CDD:292424 21/87 (24%)
DMPK_coil 878..939 CDD:117396 14/66 (21%)
C1 1043..1092 CDD:237996 7/63 (11%)
PH_MRCK 1102..1236 CDD:269949 39/142 (27%)
CNH 1262..1527 CDD:279162
RokNP_536796.2 STKc_ROCK 61..411 CDD:270747 178/357 (50%)
S_TKc 87..349 CDD:214567 144/266 (54%)
SbcC 484..1088 CDD:223496 128/673 (19%)
Rho_Binding 963..1027 CDD:286056 8/66 (12%)
PH_ROCK 1134..1250 CDD:269948 37/128 (29%)
C1 1254..1307 CDD:197519 2/6 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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