DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CLOCK and Clk

DIOPT Version :9

Sequence 1:NP_001254772.1 Gene:CLOCK / 9575 HGNCID:2082 Length:846 Species:Homo sapiens
Sequence 2:NP_001014576.1 Gene:Clk / 38872 FlyBaseID:FBgn0023076 Length:1027 Species:Drosophila melanogaster


Alignment Length:924 Identity:306/924 - (33%)
Similarity:430/924 - (46%) Gaps:197/924 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    27 EEDDKDKAK----RVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKEI 87
            |.||||..|    |.|||.||||||||||.|:.:|.:::..::|||||||||:.:|.||:.|.|.
  Fly     4 ESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNHNEA 68

Human    88 TAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQ 152
            |.:|...||:|||||.||||:|:|.||||:||||.:...:.|||.|.|||:||.|.:||.||.:.
  Fly    69 TDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNM 133

Human   153 SIFNFIPEGEHSEVYKIL--STHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVKF 215
            :|::...|.:|..:..|.  .|.::|.....   :.|.||:.|..|:.||.::..:.:.||.|||
  Fly   134 TIYDLAYEMDHEALLNIFMNPTPVIEPRQTD---ISSSNQITFYTHLRRGGMEKVDANAYELVKF 195

Human   216 IGNFKSLNSV----SSSAHNGFEG-------TIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTV 269
            :|.|::..:.    ||...||..|       ..|:......:.::.||.|.|:..||.|:||..:
  Fly   196 VGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSII 260

Human   270 EEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKG 334
            :..:.||||:||:|||||||||||||||||:||||||||||||||.|||:::..|||.|.|.|:|
  Fly   261 DPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEG 325

Human   335 KSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRRE---LGIEESLP 396
            |||||||||||||||||||.||::|||:||:|:::||||.|||||||..:.|:|   .|...|:.
  Fly   326 KSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSIT 390

Human   397 ETAADK-------SQDSGS------DNRINTVSLKEAL----------------ERFDHSPTPSA 432
            ...:.|       |..|.|      |..:::.:|...|                ...|.||..||
  Fly   391 NNGSSKVIASTGTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWSA 455

Human   433 SS---RSSRKSSHTAVSDPSSTPTKIPTDTSTPPRQHLPAHEKMVQRRSSFSSQSINSQSVGSSL 494
            |:   ..|.:.:....|.|:|:...| :.|...|:         .:|:..|.:...|.....|..
  Fly   456 SAVQPSGSCQINPLKTSRPASSYGNI-SSTGISPK---------AKRKCYFYNNRGNDSDSTSMS 510

Human   495 TQPVMSQATNLPIPQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVH 559
            |..|.|:.:.:......||.|.|      .|.:...|....  :::.|.||::..:.|:|....|
  Fly   511 TDSVTSRQSMMTHVSSQSQRQRS------HHREHHRENHHN--QSHHHMQQQQQHQNQQQQHQQH 567

Human   560 GQGLQMFLQQS------NPGLNFGSVQLSSGNSSNIQQ--------------------------- 591
             |.||..||.:      .|.|...|.|:.:||:....|                           
  Fly   568 -QQLQQQLQHTVGTPKMVPLLPIASTQIMAGNACQFPQPAYPLASPQLVAPTFLEPPQYLTAIPM 631

Human   592 ------------LAPINMQGQ---------VVPT-NQIQSGMNTGHIGTTQHMIQQQTLQSTSTQ 634
                        |:|:.:|.|         :.|| :|:|..:...|....:.::|||  ......
  Fly   632 QPVIAPFPVAPVLSPLPVQSQTDMLPDTVVMTPTQSQLQDQLQRKHDELQKLILQQQ--NELRIV 694

Human   635 SQQNVLSGHSQQTSLPSQ--TQSTLTAPLYNTMVISQPAAGSMVQIPSSMPQNSTQSAAVTT--- 694
            |:|.:||.::....:.|.  ....:||.....:..|.....:.....:..||.:....|:.:   
  Fly   695 SEQLLLSRYTYLQPMMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQFNQYGFALNSEQM 759

Human   695 -FTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMGQVVTAYPTFATQQQQSQTLSVTQQQQ 758
             ..||:|:...|.|.|.|:                           .....|||.|:.|..||..
  Fly   760 LNQQDQQMMMQQQQNLHTQ---------------------------HQHNLQQQHQSHSQLQQHT 797

Human   759 QQSSQEQQLTSVQQPSQAQLTQPPQQFLQTSRLLHGNPSTQLILSAAFPLQQSTFPQSHHQQHQS 823
            ||..|:||....||..|.|..|..||                                 .||.|.
  Fly   798 QQQHQQQQQQQQQQQQQQQQQQQQQQ---------------------------------QQQQQQ 829

Human   824 QQQQQLSRHRTDSL 837
            ||||||...:.:.:
  Fly   830 QQQQQLQLQQQNDI 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLOCKNP_001254772.1 HLH 32..86 CDD:238036 31/57 (54%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O08785 32..47 10/18 (56%)
PAS 109..>175 CDD:307226 29/67 (43%)
PAS_3 274..377 CDD:330807 79/102 (77%)
Interaction with NR3C1. /evidence=ECO:0000250|UniProtKB:O08785 371..845 123/563 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..411 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..495 18/93 (19%)
Interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:O08785 450..570 28/119 (24%)
Med15 <496..>686 CDD:312941 48/246 (20%)
Implicated in the circadian rhythmicity. /evidence=ECO:0000250 514..564 11/49 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 624..654 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..783 7/18 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 811..846 9/27 (33%)
ClkNP_001014576.1 HLH 16..68 CDD:238036 29/51 (57%)
PAS 93..153 CDD:214512 26/59 (44%)
PAS 264..366 CDD:238075 78/101 (77%)
PAS_11 265..368 CDD:291273 79/102 (77%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 198 1.000 Domainoid score I3074
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 415 1.000 Inparanoid score I1839
Isobase 1 0.950 - 0 Normalized mean entropy S6186
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002532
OrthoInspector 1 1.000 - - otm41707
orthoMCL 1 0.900 - - OOG6_105251
Panther 1 1.100 - - O PTHR46055
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4514
SonicParanoid 1 1.000 - - X1900
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.940

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