Protein Alignment GABBR2 and gabbr2

DIOPT Version :10

• Sequence 1: NP_005449.5
• Gene: GABBR2 / 9568
• HGNCID: 4507
• Length: 941
• Species: Homo sapiens
• Sequence 2: NP_001137515.1
• Gene: gabbr2 / 560267
• ZFINID: ZDB-GENE-060503-620
• Length: 935
• Species: Danio rerio
• Alignment Length: 888
• Identity: 700/888 - (78%)
• Similarity: 780/888 - (87%)
• Gaps: 8/888 - (0%)

Human    56 LSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDA 120
            |.||.|||:.:.....||.:|:.|||:|||:.|| ||....:.|..::|||||||||||:||:||
Zfish    54 LPIMVLMPMNESALMSSISQGIEPAVQLAIQHIR-ESRQYSFSLITKIYDTECDNAKGLRAFFDA 117

Human   121 IKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPA 185
            |.|||.|||:||||||||||||||||:||||||||||||||||||:||||.||||||||||||||
Zfish   118 ICYGPKHLMIFGGVCPSVTSIIAESLEGWNLVQLSFAATTPVLADRKKYPNFFRTVPSDNAVNPA 182

Human   186 ILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRI 250
            ::|.|..|.|.||||||||||||||||||||..|...||:|:||||||||||.:|||||.|||||
Zfish   183 VVKFLNFYNWSRVGTLTQDVQRFSEVRNDLTNELEKADIQIADTESFSNDPCVNVKKLKDNDVRI 247

Human   251 ILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYI 315
            |:||||:|:|||||||||..|||||||||||||||:.:||||    |||:.|..:.||.||||||
Zfish   248 IIGQFDENLAAKVFCCAYNLNMYGSKYQWIIPGWYQGNWWEQ----ANSTNCTTRKLLTAMEGYI 308

Human   316 GVDFEPLSSKQIKTISGKTPQQYEREYNNKR--SGVGPSKFHGYAYDGIWVIAKTLQRAMETLHA 378
            .|||||||:||||.|||:|||:||||||.:|  .||..|||||:||||||||||||.|.||.|..
Zfish   309 SVDFEPLSAKQIKGISGRTPQEYEREYNRERDQKGVETSKFHGFAYDGIWVIAKTLTRVMELLRH 373

Human   379 SSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYN 443
            ..||....:|...|..:|:::|:.|||||||||||||:||||||||||||||||:.:||||||||
Zfish   374 KERHDMYHNFTVDDREVGKMVLDVMNETNFFGVTGQVMFRNGERMGTIKFTQFQEGQEVKVGEYN 438

Human   444 AVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRN 508
            |:||.|::||:||||||.|||||:|.:..|.|:|::|||||||.:|||||:|..|||||||||||
Zfish   439 AIADVLDLINNTIRFQGVEPPKDRTFVRLQRRQINVPLYSILSTITILGMLMGGAFLFFNIKNRN 503

Human   509 QKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFA 573
            .:|||||||||||||||||||||||||||||||||||:|.||||||||||||.||||||||||||
Zfish   504 HRLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSDKEFETLCTVRTWILIVGYTTAFGAMFA 568

Human   574 KTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRD 638
            ||||||||||||||||||||||||.:|||||||||||||||||.||||:||||:||:|.||.|||
Zfish   569 KTWRVHAIFKNVKMKKKIIKDQKLFIIVGGMLLIDLCILICWQIVDPLKRTVEEYSLEADPQGRD 633

Human   639 ISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMC 703
            |:|||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   634 IAIRPFLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMC 698

Human   704 IIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKK 768
            ||||||||||||||||||||||||||||||||||||||||.:|:||||||||||||.:|||||||
Zfish   699 IIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKFVTMRTNPDAATQNRRLKFTQNQKK 763

Human   769 EDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQE 833
            |||||||||||||||:||||:||||:|||||||||||||:|||||||||||||||.||||||||:
Zfish   764 EDSKTSTSVTSVNQANTSRLDGLQSDNHRLRMKITELDKELEEVTMQLQDTPEKTPYIKQNHYQD 828

Human   834 LNDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPI 898
            .|:||::.|||:..||.|: |||||:|.||.||.:.:|||..:.|:|||||||||||||||||||
Zfish   829 ANNILSIRNFTDGKDGEKS-LKNHLEQKPQAQWGSADPSRISRGPLEDINSPEHIQRRLSLQLPI 892

Human   899 LHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL 941
            ||||||||||||||||.||..||::||||||:|||:|||||||
Zfish   893 LHHAYLPSIGGVDASCSSPTSSPSSSPRHRHMPPSYRVMVSGL 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABBR2	NP_005449.5	PBP1_GABAb_receptor	58..460	CDD:380589	287/403 (71%)
		7tmC_GABA-B-R2	480..749	CDD:320421	245/268 (91%)
		TM helix 1	480..505	CDD:320421	19/24 (79%)
		TM helix 2	517..538	CDD:320421	20/20 (100%)
		TM helix 3	554..578	CDD:320421	22/23 (96%)
		TM helix 4	597..617	CDD:320421	17/19 (89%)
		TM helix 5	653..679	CDD:320421	25/25 (100%)
		TM helix 6	688..711	CDD:320421	22/22 (100%)
		TM helix 7	718..743	CDD:320421	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..790		25/26 (96%)
		GBR2_CC	779..817	CDD:465774	33/37 (89%)
gabbr2	NP_001137515.1	PBP1_GABAb_receptor	56..455	CDD:380589	287/403 (71%)
		7tmC_GABA-B-R2	475..744	CDD:320421	245/268 (91%)
		TM helix 1	475..500	CDD:320421	19/24 (79%)
		TM helix 2	512..533	CDD:320421	20/20 (100%)
		TM helix 3	549..573	CDD:320421	22/23 (96%)
		TM helix 4	592..612	CDD:320421	17/19 (89%)
		TM helix 5	648..674	CDD:320421	25/25 (100%)
		TM helix 6	683..706	CDD:320421	22/22 (100%)
		TM helix 7	713..738	CDD:320421	24/24 (100%)
		GBR2_CC	774..812	CDD:465774	33/37 (89%)