Protein Alignment GABBR2 and gabbr2

DIOPT Version :10

• Sequence 1: NP_005449.5
• Gene: GABBR2 / 9568
• HGNCID: 4507
• Length: 941
• Species: Homo sapiens
• Sequence 2: NP_001016007.2
• Gene: gabbr2 / 548761
• XenbaseID: XB-GENE-5815161
• Length: 962
• Species: Xenopus tropicalis
• Alignment Length: 952
• Identity: 796/952 - (83%)
• Similarity: 856/952 - (89%)
• Gaps: 22/952 - (2%)

Human     3 SPRSSGQPG--------PPP----PPPPPPARLLLLLLLPLLLPLAPGAWGWARGAP-RPPPSSP 54
            :|:::|..|        |.|    |..||..     |||.|.|.|.||....:||.. ..|.:..
 Frog    20 TPQAAGAGGAESATGVSPKPAIQMPMLPPQC-----LLLVLGLGLGPGFVYGSRGTTIEQPANGT 79

Human    55 PLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYD 119
            .|||||||||.:.||||:|||||||||:|||:||||.|||.||||||:||||.||||:|||||||
 Frog    80 SLSIMGLMPLNETVAKGNIGRGVLPAVQLAIDQIRNISLLHPYFLDLKLYDTACDNAQGLKAFYD 144

Human   120 AIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNP 184
            |||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
 Frog   145 AIKYGPNHLMVFGGVCPSVTSIIAESLKGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNP 209

Human   185 AILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVR 249
            ||:|.|||::||||||||||:||||||||||||.|....|:|:||||||||||:|||||||||||
 Frog   210 AIVKFLKHFKWKRVGTLTQDIQRFSEVRNDLTGELEDSAIQIADTESFSNDPCSSVKKLKGNDVR 274

Human   250 IILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGY 314
            ||:||||::|||||||||::|:||||||||||||||:..||:|    ||:|.|..||||.|||||
 Frog   275 IIIGQFDEHMAAKVFCCAFDEDMYGSKYQWIIPGWYQALWWQQ----ANTSTCSTKNLLTAMEGY 335

Human   315 IGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHAS 379
            |||||||||:||||||||:||||||:|||.||:||.|||||||||||||||||||.||:|.|::|
 Frog   336 IGVDFEPLSTKQIKTISGRTPQQYEKEYNEKRAGVEPSKFHGYAYDGIWVIAKTLHRALEYLYSS 400

Human   380 SRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNA 444
            .:.|||||||||||.||:|.|:||||||||||||||||||||||||||||||||.:|||||||||
 Frog   401 KQRQRIQDFNYTDHKLGKIFLDAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDGKEVKVGEYNA 465

Human   445 VADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQ 509
            |||:||:|||||||||.|||||:|.|.|:.|:|.||||||||.|||:||||||.|||||||||||
 Frog   466 VADSLELINDTIRFQGVEPPKDQTFIREERRQIYLPLYSILSTLTIIGMIMASTFLFFNIKNRNQ 530

Human   510 KLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAK 574
            ||||||||||||||||||||||||||||||||||||..|||||||||||||||||||||||||||
 Frog   531 KLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSANTFETLCTVRTWILTVGYTTAFGAMFAK 595

Human   575 TWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDI 639
            ||||||||||||||||||||||||||||||||||||||||||.||||:||||:|::|||||||||
 Frog   596 TWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQIVDPLKRTVEEYNLEPDPAGRDI 660

Human   640 SIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCI 704
            :|||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   661 AIRPFLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCI 725

Human   705 IGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKE 769
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||
 Frog   726 IGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTHNQKKE 790

Human   770 DSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQEL 834
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
 Frog   791 DSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQDL 855

Human   835 NDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPIL 899
            ||||::.|||::.||.||:||||.||....||||.|.|:|.||||||||||||||||||||||||
 Frog   856 NDILSIRNFTDNKDGEKAVLKNHHDQKASSQWNTIESSKTSKDPIEDINSPEHIQRRLSLQLPIL 920

Human   900 HHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL 941
            |||||||||||||||.||||||:||||||||.|||:||||||
 Frog   921 HHAYLPSIGGVDASCASPCVSPSASPRHRHVQPSFQVMVSGL 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABBR2	NP_005449.5	PBP1_GABAb_receptor	58..460	CDD:380589	335/401 (84%)
		7tmC_GABA-B-R2	480..749	CDD:320421	256/268 (96%)
		TM helix 1	480..505	CDD:320421	21/24 (88%)
		TM helix 2	517..538	CDD:320421	20/20 (100%)
		TM helix 3	554..578	CDD:320421	23/23 (100%)
		TM helix 4	597..617	CDD:320421	19/19 (100%)
		TM helix 5	653..679	CDD:320421	25/25 (100%)
		TM helix 6	688..711	CDD:320421	22/22 (100%)
		TM helix 7	718..743	CDD:320421	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..790		25/26 (96%)
		GBR2_CC	779..817	CDD:465774	37/37 (100%)
gabbr2	NP_001016007.2	PBP1_GABAb_receptor	83..481	CDD:380589	335/401 (84%)
		7tmC_GABA-B-R2	501..770	CDD:320421	256/268 (96%)
		TM helix 1	501..526	CDD:320421	21/24 (88%)
		TM helix 2	538..559	CDD:320421	20/20 (100%)
		TM helix 3	575..599	CDD:320421	23/23 (100%)
		TM helix 4	618..638	CDD:320421	19/19 (100%)
		TM helix 5	674..700	CDD:320421	25/25 (100%)
		TM helix 6	709..732	CDD:320421	22/22 (100%)
		TM helix 7	739..764	CDD:320421	24/24 (100%)
		GBR2_CC	800..838	CDD:465774	37/37 (100%)