DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABBR2 and GABA-B-R2

DIOPT Version :10

Sequence 1:NP_005449.5 Gene:GABBR2 / 9568 HGNCID:4507 Length:941 Species:Homo sapiens
Sequence 2:NP_001287456.1 Gene:GABA-B-R2 / 42561 FlyBaseID:FBgn0027575 Length:1224 Species:Drosophila melanogaster


Alignment Length:1024 Identity:368/1024 - (35%)
Similarity:538/1024 - (52%) Gaps:154/1024 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    19 PPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVEL 83
            |.|.||.|||             |:....|....| .:.|.|..|....|.....||||:|:|:|
  Fly     8 PFASLLFLLL-------------WSTACGRTAKRS-DVYIAGFFPYGDGVENSYTGRGVMPSVKL 58

Human    84 AIEQIRNE--SLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESL 146
            |:..: ||  .:|..|.|.:...||:|:.|.|:|:|:|.:..|||.:|:||..|..||..||::.
  Fly    59 ALGHV-NEHGKILANYRLHMWWNDTQCNAAVGVKSFFDMMHSGPNKVMLFGAACTHVTDPIAKAS 122

Human   147 QGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEV 211
            :.|:|.|||:|.|.|:.. |..:|.|||.|||:||.|...|.|||.:.|.||||:.|:..|:|..
  Fly   123 KHWHLTQLSYADTHPMFT-KDAFPNFFRVVPSENAFNAPRLALLKEFNWTRVGTVYQNEPRYSLP 186

Human   212 RNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSK 276
            .|.:...|...::|:.:|:||.||...|:|||:..|||||||.|:::.|.|.||.||:.:|||..
  Fly   187 HNHMVADLDAMEVEVVETQSFVNDVAESLKKLREKDVRIILGNFNEHFARKAFCEAYKLDMYGRA 251

Human   277 YQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYERE 341
            |||:|...|...||    .....|.|..:.:..|:||.|.||..|||:....|::|.|..:|..|
  Fly   252 YQWLIMATYSTDWW----NVTQDSECSVEEIATALEGAILVDLLPLSTSGDITVAGITADEYLVE 312

Human   342 YNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNET 406
            |:..| |...|:||||.|||||..|..:|..     |..|...:..|:|.......:.|.|:..|
  Fly   313 YDRLR-GTEYSRFHGYTYDGIWAAALAIQYV-----AEKREDLLTHFDYRVKDWESVFLEALRNT 371

Human   407 NFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEI-INDTIRFQGSEPPKDKTII 470
            :|.||||.|.|.|.||...|...|||..:..|:|||::....|:: :...:::.|..||||:|:|
  Fly   372 SFEGVTGPVRFYNNERKANILINQFQLGQMEKIGEYHSQKSHLDLSLGKPVKWVGKTPPKDRTLI 436

Human   471 LEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIF 535
            ..:..:::..:|.:.::.:::|:|:|:.||.||||.|||:.||||||::|||||:|.|::|.||.
  Fly   437 YIEHSQVNPTIYIVSASASVIGVIIATVFLAFNIKYRNQRYIKMSSPHLNNLIIVGCMMTYLSII 501

Human   536 LFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVI 600
            ..|||.:..|...|..:||.|.|||..|::.:|||||:||||||:||.::|:.||:|||.:|.::
  Fly   502 FLGLDTTLSSVAAFPYICTARAWILMAGFSLSFGAMFSKTWRVHSIFTDLKLNKKVIKDYQLFMV 566

Human   601 VGGMLLIDLCILICWQAVDPLRRTVEKYSMEP------DPAGRDISIRPLLEHCENTHMTIWLGI 659
            ||.:|.||:.|:..||..||..|  |...:||      |    |:.:.|..|:|::.||||::.|
  Fly   567 VGVLLAIDIAIITTWQIADPFYR--ETKQLEPLHHENID----DVLVIPENEYCQSEHMTIFVSI 625

Human   660 VYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIV 724
            :|||||||::||.|||||||:||||||||||:||.|||||.|.|:.|||:|.:..|:.::.|.::
  Fly   626 IYAYKGLLLVFGAFLAWETRHVSIPALNDSKHIGFSVYNVFITCLAGAAISLVLSDRKDLVFVLL 690

Human   725 ALVIIFCSTITLCLVFVPK----LITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQAST 785
            :..||||:|.|||||||||    |:.|:.||.... ::|.:.|.....::.:..:||..:.|   
  Fly   691 SFFIIFCTTATLCLVFVPKVRLVLVELKRNPQGVV-DKRVRATLRPMSKNGRRDSSVCELEQ--- 751

Human   786 SRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIK-------QNHYQELNDILN---- 839
             ||..:::.|.|.|..:.|.:.:|:.:..:|  .||...:|.       .|...||..|||    
  Fly   752 -RLRDVKNTNCRFRKALMEKENELQALIRKL--GPEARKWIDGVTCTGGSNVGSELEPILNDDIV 813

Human   840 ------------LGNFTESTDGGKAILKNHLDQN------------PQL----------QWNTTE 870
                        ....||.| ...::...|::.:            |.|          :.::..
  Fly   814 RLSAPPVRREMPSTTVTEMT-SVDSVTSTHVEMDNSFVSVQSTVMAPSLPPKKKKQSIVEHHSHA 877

Human   871 PSRTCKDPIEDINSPEHIQRRLSLQLPIL-----------------HHAYL-----------PSI 907
            |:.|...||:. ...:|:|:...:|...|                 ||.:|           .:|
  Fly   878 PAPTMMQPIQQ-QLQQHLQQHQQMQQQHLQQQQHQQMQQQQQQQQHHHRHLEKRNSVSAQTDDNI 941

Human   908 GGV---------------------------DASCVSPCVSPTASPRHRH 929
            |.:                           |:...:|...|..|..||:
  Fly   942 GSITSTAGKRSGGDCSSMRERRQSTASRHYDSGSQTPTARPKYSSSHRN 990

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABBR2NP_005449.5 PBP1_GABAb_receptor 58..460 CDD:380589 160/404 (40%)
7tmC_GABA-B-R2 480..749 CDD:320421 142/278 (51%)
TM helix 1 480..505 CDD:320421 8/24 (33%)
TM helix 2 517..538 CDD:320421 11/20 (55%)
TM helix 3 554..578 CDD:320421 14/23 (61%)
TM helix 4 597..617 CDD:320421 8/19 (42%)
TM helix 5 653..679 CDD:320421 18/25 (72%)
TM helix 6 688..711 CDD:320421 15/22 (68%)
TM helix 7 718..743 CDD:320421 13/24 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..790 6/26 (23%)
GBR2_CC 779..817 CDD:465774 8/37 (22%)
GABA-B-R2NP_001287456.1 PBP1_GABAb_receptor 32..426 CDD:380589 160/405 (40%)
7tmC_GABA-B-R2 446..719 CDD:320421 142/278 (51%)
TM helix 1 446..471 CDD:320421 8/24 (33%)
TM helix 2 483..504 CDD:320421 11/20 (55%)
TM helix 3 520..544 CDD:320421 14/23 (61%)
TM helix 4 563..583 CDD:320421 8/19 (42%)
TM helix 5 619..645 CDD:320421 18/25 (72%)
TM helix 6 654..677 CDD:320421 15/22 (68%)
TM helix 7 684..709 CDD:320421 13/24 (54%)
PHA03307 934..>1161 CDD:223039 8/57 (14%)

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